WormBase Tree Display for Gene: WBGene00001137

WBGene00001137 SMap: S_parent: Sequence: B0365
  Identity: Version: 1
    Name: CGC_name: eat-6 Person_evidence: WBPerson32
      Sequence_name: B0365.3
      Molecular_name: B0365.3
        B0365.3.1
        CE07721
        B0365.3.2
      Other_name: NaK/1
        spa-1
        CELE_B0365.3 Accession_evidence: NDB BX284605
      Public_name: eat-6
    DB_info: Database: AceView gene 5N608
        WormQTL gene WBGene00001137
        WormFlux gene WBGene00001137
        NDB locus_tag CELE_B0365.3
        Panther gene CAEEL|WormBase=WBGene00001137|UniProtKB=P90735
          family PTHR43294
        NCBI gene 179796
        RefSeq protein NM_073868.6
        TrEMBL UniProtAcc P90735
        UniProt_GCRP UniProtAcc P90735
        OMIM gene 182310
            182340
            182350
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:23 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: eat
    Allele (46)
    Legacy_information: [Leon Avery] Strong relaxation-defective. Pharynx oftens fails to relax, or relaxes slowly. There are long yawns, where the corpus stays open for seconds, punctuated with erratic partial relaxations. The terminal bulb is usually more strongly affected than the corpus, but the motions of the two are precisely synchronized. Relaxation transient is reduced in size in electropharyngeograms.
      See also ad601, ad792
      [C.elegansII] ad467 : strong relaxation-defective.Pharynx oftens fails to relax, or relaxes slowly. There are long yawns, where the corpus stays open for seconds, punctuated with erratic partial relaxations. The terminal bulb is usually more strongly affected than the corpus, but the motions of the two are precisely synchronized. Relaxation transient is reduced in size in electropharyngeograms. Hypersensitive to inhibitors of Na/K ATPase. Synthetic lethal with eat-11(ad541).OA2: ad601xri, ad792. Cloned: encodes alpha subunit of Na/K ATPase (pka spa-1). [Avery 1993; DA]
    Strain: WBStrain00036106
      WBStrain00037778
      WBStrain00005464
      WBStrain00005489
      WBStrain00005507
      WBStrain00005516
      WBStrain00005529
    RNASeq_FPKM (74)
    GO_annotation (36)
    Ortholog: WBGene00058978 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00024860 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00031016 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
      WBGene00162745 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
      WBGene00102400 Pristionchus pacificus From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00135583 Caenorhabditis japonica From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00100369 Pristionchus pacificus From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00222040 Brugia malayi From_analysis: WormBase-Compara
      CSP26.g12282 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP29.g14226 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g18066 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP39.g13322 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g9516 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_15666.g25122 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cang_2012_03_13_19596.g26282 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-eat-6 Caenorhabditis nigoni From_analysis: WormBase-Compara
      FL83_12079 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_017704 Caenorhabditis remanei From_analysis: WormBase-Compara
      Pan_g15530 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_50273700 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrV_pilon.g16178 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00243636 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00258421 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00294910 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0002921 Drosophila melanogaster From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-001212-6 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-001212-7 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-001212-8 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-001212-1 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-001212-2 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-001212-3 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-001212-4 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-001212-5 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-020501-1 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:799 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:800 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:801 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:14073 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:88105 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:1351335 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:88106 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:88107 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:2167 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:2168 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:2169 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:61952 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Paralog (14)
    Structured_description: Concise_description: eat-6 encodes an ortholog of the alpha subunit of a sodium/potassium ATPase, which in turn affects Na+,K(+)-ATPase activity of membranes by affecting the level of the phosphorylated intermediate of the Na+,K(+)-ATPase; EAT-6 affects relaxation of the pharyngeal muscles, fertility (and thus affects feeding); EAT-6 also affects body length, life span, and ASE, ASI and ASJ axonal outgrowth. Paper_evidence: WBPaper00001709
            WBPaper00002371
            WBPaper00003150
            WBPaper00003257
            WBPaper00003521
          Curator_confirmed: WBPerson48
            WBPerson363
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables P-type sodium:potassium-exchanging transporter activity. Involved in several processes, including action potential; monoatomic ion transport; and regulation of muscle contraction. Located in membrane. Expressed in several structures, including coelomocyte; intestine; neurons; pharynx; and vulval muscle. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2DD; alternating hemiplegia of childhood; and brain disease (multiple). Is an ortholog of human ATP1A3 (ATPase Na+/K+ transporting subunit alpha 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:1574 Homo sapiens Paper_evidence: WBPaper00045914
          Curator_confirmed: WBPerson324
          Date_last_updated: 06 Jun 2019 00:00:00
    Potential_model (12)
  Models_disease_asserted: WBDOannot00000704
  Molecular_info: Corresponding_CDS: B0365.3
    Corresponding_transcript: B0365.3.1
      B0365.3.2
    Other_sequence (276)
    Associated_feature (18)
  Experimental_info: RNAi_result (34)
    Expr_pattern: Expr8226
      Expr8228
      Expr12845
      Expr1017676
      Expr1030726
      Expr1143152
      Expr2011160
      Expr2029396
    Drives_construct: WBCnstr00013194
      WBCnstr00022897
      WBCnstr00037068
    Construct_product: WBCnstr00013192
      WBCnstr00037068
    Microarray_results (26)
    Expression_cluster (174)
    Interaction (116)
  Map_info (4)
  Reference (55)
  Remark: [MW Davis] Transformation rescue.
  Method: Gene