WormBase Tree Display for Gene: WBGene00000883

WBGene00000883 SMap: S_parent: Sequence: Y75B12B
  Identity: Version: 2
    Name: CGC_name: cyn-7 Person_evidence: WBPerson466
      Sequence_name: Y75B12B.2
      Molecular_name: Y75B12B.2
        Y75B12B.2.1
        CE20371
      Other_name: cyp-7 Person_evidence: WBPerson466
        CELE_Y75B12B.2 Accession_evidence: NDB BX284605
      Public_name: cyn-7
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 20 Sep 2004 16:20:03 WBPerson1971 Name_change: CGC_name: cyp-7 -> cyn-7
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cyn
    Allele (26)
    Legacy_information: [C.elegansII] NMK. Cyclophilin family. Signal peptide. [TP]
    Strain: WBStrain00032910
    RNASeq_FPKM (74)
    GO_annotation (11)
    Ortholog: WBGene00057760 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00037970 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            WormBase-Compara
      WBGene00097504 Pristionchus pacificus From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00029206 Caenorhabditis briggsae From_analysis: OMA
      WBGene00037969 Caenorhabditis briggsae From_analysis: OMA
      WBGene00064228 Caenorhabditis remanei From_analysis: OMA
      WBGene00057761 Caenorhabditis remanei From_analysis: OMA
      WBGene00149830 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            WormBase-Compara
      WBGene00154586 Caenorhabditis brenneri From_analysis: OMA
      WBGene00135996 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00056729 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00191549 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00059140 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00130376 Caenorhabditis japonica From_analysis: TreeFam
      WBGene00154966 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00226950 Brugia malayi From_analysis: WormBase-Compara
      WBGene00230067 Brugia malayi From_analysis: WormBase-Compara
      CSP21.g954 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g14269 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g2726 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g12052 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP39.g28419 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g14609 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Csp11.Scaffold629.g9555 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00767.g15294 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_19644 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_019591 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g10086 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g14092 Panagrellus redivivus From_analysis: WormBase-Compara
      Pan_g6527 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_50398700 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrV_pilon.g16728 Caenorhabditis elegans From_analysis: WormBase-Compara
      nigoni.pc_2016.07.11_007.g26874 Caenorhabditis nigoni From_analysis: WormBase-Compara
      WBGene00238536 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00246665 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00274566 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00304853 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00304854 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00260945 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00285843 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000002562 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoInspector
            SonicParanoid
      SGD:S000004543 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      FB:FBgn0004432 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      FB:FBgn0036415 Drosophila melanogaster From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-030131-7459 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-030131-8556 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-051030-126 Danio rerio From_analysis: Hieranoid
            OMA
            OrthoInspector
      HGNC:9253 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      HGNC:9259 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      HGNC:33996 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            SonicParanoid
      HGNC:33998 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            SonicParanoid
      HGNC:24369 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            SonicParanoid
      HGNC:33995 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      HGNC:33999 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            SonicParanoid
      HGNC:33997 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            SonicParanoid
      HGNC:53889 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            SonicParanoid
      MGI:2145814 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      MGI:97749 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      RGD:3372 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      RGD:628670 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      RGD:1559682 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            SonicParanoid
      RGD:2321083 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      RGD:6493676 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
    Paralog (18)
    Structured_description: Concise_description: cyn-7 encodes a cyclophilin A isoform; while not tested for peptidyl-prolyl isomerase activity in vitro, it is very similar to CYN-3 and closely resembles the prototypical CypA, and is therefore likely to be a member of the cytosolic CsA-binding cyclophilin subfamily; CYN-7 was required for embryonic viability in one set of mass RNAi assays. Paper_evidence: WBPaper00002472
            WBPaper00004651
            WBPaper00026884
          Curator_confirmed (2)
          Date_last_updated: 20 Mar 2007 00:00:00
      Automated_description: Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to be located in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including Bell's palsy; aggressive periodontitis; and gastrointestinal system cancer (multiple). Is an ortholog of human PPIA (peptidylprolyl isomerase A); PPIAL4C (peptidylprolyl isomerase A like 4C); and PPIF (peptidylprolyl isomerase F). Paper_evidence: WBPaper00065943
          Curator_confirmed (2)
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:4947 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9253)
      DOID:9261 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9253)
      DOID:1474 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9253)
      DOID:526 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9253)
      DOID:12506 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9253)
  Molecular_info: Corresponding_CDS: Y75B12B.2
    Corresponding_transcript: Y75B12B.2.1
    Other_sequence (63)
    Associated_feature: WBsf653438
      WBsf653439
      WBsf977373
      WBsf977374
      WBsf235037
  Experimental_info: RNAi_result: WBRNAi00111702 Inferred_automatically: RNAi_primary
      WBRNAi00001940 Inferred_automatically: RNAi_primary
      WBRNAi00058420 Inferred_automatically: RNAi_primary
      WBRNAi00027817 Inferred_automatically: RNAi_primary
      WBRNAi00083853 Inferred_automatically: RNAi_primary
      WBRNAi00083670 Inferred_automatically: RNAi_primary
      WBRNAi00021427 Inferred_automatically: RNAi_primary
      WBRNAi00076846 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram1064
      Expr1022229
      Expr1030548
      Expr1161841
      Expr2010675
      Expr2028915
    Drives_construct: WBCnstr00037223
    Construct_product: WBCnstr00037223
    Microarray_results (22)
    Expression_cluster (195)
    Interaction (165)
  Map_info: Map: V Position: 7.51429 Error: 0.006122
    Positive: Positive_clone: Y75B12B Inferred_automatically: From sequence, transcript, pseudogene data
        ZK520
    Pseudo_map_position
  Reference (11)
  Remark: signal_peptide
    [Page AM] From partial Est sequence CEESN11F. Is transpliced by SL-1. Isolated from mixed stage cDNA using SL1, and known 3' seq from CEESN11F.
    [Page AM] Have been unable to accurately map this gene to the YAC grid- as it cross-hybridises with the other highly homologous gene.
    PPIase or cyclophilin, EC 5.2.1.8
    This gene has been renamed with approval of the CGC (cyp-7->cyn-7) Person_evidence: WBPerson466
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene