[C.elegansII] pk91 : Tc1 insertion, no known phenotype. Encodes protein with significant similarity to proteases of Cathepsin B family (EST cm01a5). [IA]
Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Located in lysosome. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease of the nervous system (multiple); carcinoma (multiple); and type 2 diabetes mellitus. Is an ortholog of human CTSB (cathepsin B).