WormBase Tree Display for Gene: WBGene00000776

WBGene00000776 Evidence: Paper_evidence: WBPaper00004821
  SMap: S_parent: Sequence: T03E6
  Identity: Version: 1
    Name (5)
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cpl
    Allele (188)
    Strain: WBStrain00035678
    RNASeq_FPKM (74)
    GO_annotation (34)
    Ortholog: WBGene00067953 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00041124 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00155220 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00099255 Pristionchus pacificus From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00190890 Caenorhabditis brenneri From_analysis: TreeFam
            WormBase-Compara
      WBGene00126614 Caenorhabditis japonica From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00233236 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g1872 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g1709 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g2770 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g669 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g18850 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g1516 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g10476 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g6427 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g8222 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g14537 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_06244.g20148 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-cpl-1 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold630.g20101 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_02311.g25924 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_20530 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_020575 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g06640 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g18590 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_50340000 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrV_pilon.g17198 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00238557 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00262333 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00288541 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0013770 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            SonicParanoid
      ZFIN:ZDB-GENE-980526-285 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoInspector
            SonicParanoid
      ZFIN:ZDB-GENE-030131-106 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoInspector
            SonicParanoid
      ZFIN:ZDB-GENE-121214-52 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoInspector
            SonicParanoid
      ZFIN:ZDB-GENE-040718-61 Danio rerio From_analysis: OMA
            OrthoInspector
            Panther
      ZFIN:ZDB-GENE-041010-76 Danio rerio From_analysis: Hieranoid
            Inparanoid
            SonicParanoid
      ZFIN:ZDB-GENE-121214-37 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoInspector
            SonicParanoid
      ZFIN:ZDB-GENE-080215-7 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoInspector
            SonicParanoid
      ZFIN:ZDB-GENE-071004-74 Danio rerio From_analysis: Hieranoid
            Inparanoid
            SonicParanoid
      ZFIN:ZDB-GENE-121214-39 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoInspector
            SonicParanoid
      ZFIN:ZDB-GENE-071004-116 Danio rerio From_analysis: Hieranoid
            Inparanoid
            SonicParanoid
      HGNC:2537 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            PhylomeDB
            SonicParanoid
      HGNC:2538 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OrthoInspector
            SonicParanoid
      MGI:88564 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      MGI:1349426 Mus musculus From_analysis: Inparanoid
            OrthoInspector
            SonicParanoid
      MGI:1860262 Mus musculus From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      MGI:1860275 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      MGI:1861723 Mus musculus From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      MGI:1889619 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OrthoInspector
            SonicParanoid
      MGI:1927229 Mus musculus From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      MGI:1917452 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      MGI:2151929 Mus musculus From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      MGI:1922258 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OrthoInspector
            SonicParanoid
      MGI:2682300 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      RGD:2448 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      RGD:69241 Rattus norvegicus From_analysis: Inparanoid
            OrthoInspector
            SonicParanoid
      RGD:631421 Rattus norvegicus From_analysis: Inparanoid
            OrthoInspector
            SonicParanoid
      RGD:708447 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OrthoInspector
            SonicParanoid
      RGD:1309226 Rattus norvegicus From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      RGD:631422 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OrthoInspector
            SonicParanoid
      RGD:1308751 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      RGD:1564657 Rattus norvegicus From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      RGD:631420 Rattus norvegicus From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      RGD:1303225 Rattus norvegicus From_analysis: Inparanoid
            OrthoInspector
            SonicParanoid
      RGD:1562210 Rattus norvegicus From_analysis: Inparanoid
            OrthoInspector
            SonicParanoid
      RGD:1564827 Rattus norvegicus From_analysis: Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      RGD:1560071 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      RGD:1588248 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            SonicParanoid
      RGD:2320837 Rattus norvegicus From_analysis: Inparanoid
            OrthoInspector
            SonicParanoid
    Paralog (28)
    Structured_description: Concise_description: cpl-1 encodes a member of the cathepsin L-like cysteine protease family required for embryonic viability and normal growth; expressed in eggshells and throughout early embryos, accumulates in intestinal cells during late embryogenesis, and expressed in the cuticle, gonad, and pharynx later in development. Paper_evidence: WBPaper00005099
            WBPaper00005654
            WBPaper00011657
            WBPaper00023209
          Curator_confirmed: WBPerson48
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable cysteine-type endopeptidase activity. Involved in several processes, including lipid droplet disassembly; positive regulation of vitellogenesis; and regulation of apoptosis involved in tissue homeostasis. Located in several cellular components, including lysosome; vesicle lumen; and yolk granule. Expressed in several structures, including cuticle; eggshell; hermaphrodite gonad; pharynx; and vulva. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy and type 2 diabetes mellitus. Is an ortholog of human CTSL (cathepsin L). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:11984 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2537)
      DOID:9352 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2537)
  Molecular_info: Corresponding_CDS: T03E6.7a
      T03E6.7b
    Corresponding_transcript: T03E6.7a.1
      T03E6.7b.1
    Other_sequence (287)
    Associated_feature (13)
  Experimental_info: RNAi_result (20)
    Expr_pattern (17)
    Drives_construct: WBCnstr00002531
      WBCnstr00010433
      WBCnstr00010434
      WBCnstr00019401
      WBCnstr00037285
    Construct_product: WBCnstr00010434
      WBCnstr00015512
      WBCnstr00016652
      WBCnstr00018463
      WBCnstr00018464
      WBCnstr00019401
      WBCnstr00037285
    Regulate_expr_cluster: WBPaper00064728:cpl-1(W32AY35A)_upregulated
    Antibody: WBAntibody00000451
      WBAntibody00000800
      WBAntibody00000801
      WBAntibody00000802
      WBAntibody00000803
      WBAntibody00002885
      WBAntibody00002910
    Microarray_results (23)
    Expression_cluster (236)
    Interaction (107)
  Map_info: Map: V Position: 10.72
    Positive: Positive_clone: T03E6 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4236
    Pseudo_map_position
  Reference (37)
  Remark: Sequence connection from [Hashmi S, Britton C, Lustigman S], 02/06/13 krb.
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
    [200225 pad] Modified Map position as it was a reverse physical that could not be fixed by automated methods. (10.5333)
  Method: Gene