WormBase Tree Display for Gene: WBGene00000761

WBGene00000761 Evidence: Paper_evidence: WBPaper00013270
  SMap: S_parent: Sequence: C24A11
  Identity: Version: 2
    Name: CGC_name: coq-1 Person_evidence: WBPerson247
      Sequence_name: C24A11.9
      Molecular_name: C24A11.9
        C24A11.9.1
        CE29183
      Other_name: tag-134 CGC_data_submission
        let-370 Person_evidence: WBPerson533
        CELE_C24A11.9 Accession_evidence: NDB BX284601
      Public_name: coq-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 04 Mar 2015 11:37:44 WBPerson2970 Event: Acquires_merge: WBGene00002590
              Name_change: Other_name: let-370
      Acquires_merge: WBGene00002590
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: coq
    Allele (26)
    Legacy_information: [McDowall JS] Sterile adult
      [C.elegansII] h128 : sterile adult or Mel with larval lethality. OA1: h210. [Howell et al. 1987; KR]
    Strain: WBStrain00023687
      WBStrain00035805
    RNASeq_FPKM (74)
    GO_annotation (13)
    Contained_in_operon: CEOP1248
    Ortholog: WBGene00060053 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00033280 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00133429 Caenorhabditis japonica From_analysis: OMA
            Inparanoid_8
      WBGene00222595 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g10550 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g3900 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g12732 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g1755 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g671 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g8237 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g5049 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g13323 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g9260 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g9262 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g24291 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00323.g9209 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-coq-1 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold630.g20490 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00117.g4787 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_07107 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_002580 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g09844 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g2000 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_10243100 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrI_pilon.g907 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00237450 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00275798 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00260525 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00287978 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000000207 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      FB:FBgn0051005 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-030131-4430 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:17759 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1889278 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:2319976 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Structured_description: Concise_description: coq-1 encodes a putative hexaprenyl pyrophosphate synthetase,orthologous to S. cerevisiae COQ1; COQ-1 is required for ubiquinone(coenzyme Q9) biosynthesis and for normally short lifespan; coq-1mutants have slowed pharyngeal pumping, and eventually arrest asparalysed larvae before dying; coq-1(RNAi) animals have reduced levelsof coenzyme Q9 and superoxide, and have abnormally long lifespans; coq-1mutants are not rescued by dietary coenzyme Q. Paper_evidence: WBPaper00005863
            WBPaper00028317
            WBPaper00028394
          Curator_confirmed: WBPerson567
          Date_last_updated: 26 Oct 2006 00:00:00
      Automated_description: Predicted to enable prenyltransferase activity. Involved in ubiquinone biosynthetic process. Predicted to be extrinsic component of mitochondrial inner membrane. Predicted to be part of transferase complex. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 2. Is an ortholog of human PDSS1 (decaprenyl diphosphate synthase subunit 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0070239 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17759)
  Molecular_info: Corresponding_CDS: C24A11.9
    Corresponding_transcript: C24A11.9.1
    Other_sequence (25)
    Associated_feature: WBsf716921
      WBsf981014
      WBsf983687
      WBsf983688
      WBsf983689
      WBsf1009823
      WBsf1009824
      WBsf219422
      WBsf219423
  Experimental_info: RNAi_result (36)
    Expr_pattern: Expr13707
      Expr1019532
      Expr1030467
      Expr1145088
      Expr2010461
      Expr2028701
    Drives_construct (2)
    Construct_product: WBCnstr00037297
      WBCnstr00039949
    Microarray_results (22)
    Expression_cluster (134)
    Interaction (26)
  Map_info: Map: I Position: -0.020987 Error: 0.00265
    Representative_for: WBGene00002797
    Positive: Positive_clone: C24A11 Inferred_automatically: From sequence, transcript, pseudogene data
    Negative: Outside_rearr: hDf28
      Negative_clone: C12H4
        C24H1
        C28A7
        C30A6
        F40D12
        M01A10
        M01E11
    Mapping_data: 2_point: 2537
      Multi_point: 4234
        1023
      Pos_neg_data: 2571
        2710
        4546
        4547
        5327
        5374
        3777
    Pseudo_map_position
  Reference (19)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
    [McDowall JS] Extrachromosomal arrays containing three cosmids generated, then manipulated genetically.
  Method: Gene