WormBase Tree Display for Gene: WBGene00000147

WBGene00000147 SMap: S_parent: Sequence: VF36H2L
  Identity: Version: 1
    Name: CGC_name: aph-1 Person_evidence: WBPerson498
      Sequence_name: VF36H2L.1
      Molecular_name: VF36H2L.1
        VF36H2L.1.1
        CE16526
      Other_name: pen-1
        CELE_VF36H2L.1 Accession_evidence: NDB BX284601
      Public_name: aph-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: aph
    Allele (29)
    Legacy_information: [C.elegansII] zu123 : maternal effect lethal, no anterior pharynx;resembles Glp-1 embryonic phenotype but no Lag or germ line phenotypes. Maternal rescue complete.OA1: zu147 (weaker allele).[JJ]
      or28 : mutants exhibit a recessive, fully penetrant egg-laying defect; aph-1(or28) is also maternal effect Emb.
    Strain: WBStrain00004780
      WBStrain00007372
      WBStrain00007373
      WBStrain00007374
      WBStrain00007375
    RNASeq_FPKM (74)
    GO_annotation (24)
    Contained_in_operon: CEOP1542
    Ortholog: WBGene00077507 Caenorhabditis briggsae From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00060926 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00161363 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00147743 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00137119 Caenorhabditis japonica From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00226349 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g12137 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g13497 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g8145 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g17838 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g10911 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g4294 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g6553 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g21126 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g19947 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g22474 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      Cni-aph-1 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g8126 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_03076.g28980 Caenorhabditis sinica From_analysis: WormBase-Compara
      GCK72_001414 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g09873 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g2341 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_10111500 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrI_pilon.g1765 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00237221 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00304457 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00286494 Trichuris muris From_analysis: WormBase-Compara
      WBGene00301894 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0031458 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-031118-31 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-050913-96 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:29509 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:24080 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1915568 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:3522097 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:2385110 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1562468 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1311546 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Structured_description: Concise_description: aph-1 encodes an unfamiliar protein predicted to have seven transmembrane domains; APH-1 is a component of the GLP-1/LIN-12 (Notch) pathway, is required maternally for embryonic viability, and also affects morphogenesis, egg laying, germ line proliferation, and translocation of APH-2 to the cell surface; with PEN-2, APH-1 is required for Notch pathway signaling, gamma-secretase cleavage of beta-amyloid precursor protein, and presenilin protein accumulation. Paper_evidence: WBPaper00005082
            WBPaper00005374
          Curator_confirmed: WBPerson48
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable protein-macromolecule adaptor activity. Involved in several processes, including cell differentiation; pharynx development; and protein localization to cell surface. Predicted to be located in endoplasmic reticulum. Predicted to be part of gamma-secretase complex. Human ortholog(s) of this gene implicated in coronary artery disease. Is an ortholog of human APH1A (aph-1 homolog A, gamma-secretase subunit) and APH1B (aph-1 homolog B, gamma-secretase subunit). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:3393 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:24080)
  Molecular_info: Corresponding_CDS: VF36H2L.1
    Corresponding_transcript: VF36H2L.1.1
    Other_sequence (18)
    Associated_feature: WBsf664684
      WBsf664685
      WBsf220056
      WBsf220057
  Experimental_info (8)
  Map_info: Map: I Position: 3.6794 Error: 0.007271
    Well_ordered
    Positive: Positive_clone: VF36H2L Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 2276
        2277
        5072
      Pos_neg_data: 6815
        6816
  Reference (34)
  Method: Gene