WormBase Tree Display for Gene: WBGene00000074

WBGene00000074 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 1
    Name: CGC_name: adm-2 Person_evidence: WBPerson493
      Sequence_name: C04A11.4
      Molecular_name: C04A11.4a
        C04A11.4a.1
        CE07906
        C04A11.4b
        CE52805
        C04A11.4b.1
      Other_name: CELE_C04A11.4 Accession_evidence: NDB BX284606
      Public_name: adm-2
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: adm
    Allele (182)
    Strain: WBStrain00033018
    RNASeq_FPKM (74)
    GO_annotation (17)
    Ortholog: WBGene00065291 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00029451 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00164245 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00128066 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      CBOVI.g3920 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g11893 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g8565 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g18044 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g1689 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g11156 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g7891 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g18465 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g10783 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g13304 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00059.g2990 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-adm-2 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold630.g22045 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00189.g6636 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_01577 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_025754 Caenorhabditis remanei From_analysis: WormBase-Compara
      Pan_g3503 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_X0122600 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrX_pilon.g20462 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00277995 Pristionchus pacificus From_analysis: WormBase-Compara
      FB:FBgn0265140 Drosophila melanogaster From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-030616-622 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-040912-127 Danio rerio From_analysis: Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-070809-1 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-070813-1 Danio rerio From_analysis: Hieranoid
            Inparanoid
            SonicParanoid
      ZFIN:ZDB-GENE-030131-4971 Danio rerio From_analysis: Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-070705-541 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-060929-532 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
      ZFIN:ZDB-GENE-070809-4 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-070808-1 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:215 Homo sapiens From_analysis: Hieranoid
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:190 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:197 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:193 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:216 Homo sapiens From_analysis: Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:214 Homo sapiens From_analysis: OrthoInspector
            Panther
            PhylomeDB
      HGNC:206 Homo sapiens From_analysis: Hieranoid
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:15478 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:105378 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      MGI:1333882 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      MGI:105377 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      MGI:107825 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      MGI:105376 Mus musculus From_analysis: Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      MGI:105988 Mus musculus From_analysis: Hieranoid
            OrthoInspector
            Panther
      MGI:1341813 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      RGD:620402 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            Panther
            SonicParanoid
      RGD:727820 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OrthoInspector
            Panther
      RGD:621473 Rattus norvegicus From_analysis: Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1585017 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1305278 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1566394 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OrthoInspector
            Panther
            SonicParanoid
      RGD:1583652 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            Panther
            SonicParanoid
    Paralog: WBGene00006804 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000075 Caenorhabditis elegans From_analysis: TreeFam
            WormBase-Compara
      WBGene00006324 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00016423 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00019514 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: adm-2 encodes a protein containing a snake venom disintegrin-domain and a metalloprotease-like domain (i.e., a protein of the ADAM family); like ADM-1, ADM-2 is homologous to a mammalian sperm glycoprotein (PH-30/fertilin) implicated in sperm-egg fusion, and ADM-2 might thus be a fusogenic protein mediating the merging of plasma membranes during development. Paper_evidence: WBPaper00002626
            WBPaper00012780
            WBPaper00012947
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable metalloendopeptidase activity. Predicted to be involved in membrane protein ectodomain proteolysis. Predicted to be located in endosome membrane; lysosomal membrane; and plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); endocrine gland cancer (multiple); and lung disease (multiple). Is an ortholog of human ADAM19 (ADAM metallopeptidase domain 19) and ADAM33 (ADAM metallopeptidase domain 33). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (18)
  Molecular_info: Corresponding_CDS: C04A11.4a
      C04A11.4b
    Corresponding_transcript: C04A11.4a.1
      C04A11.4b.1
    Other_sequence (12)
    Associated_feature: WBsf663500
      WBsf1007698
      WBsf1007699
      WBsf1007700
      WBsf1007701
      WBsf1024282
      WBsf1024283
      WBsf1024284
      WBsf236598
      WBsf236599
  Experimental_info: RNAi_result (11)
    Expr_pattern: Expr1014279
      Expr1030033
      Expr1143671
      Expr2009235
      Expr2027472
    Drives_construct: WBCnstr00037750
    Construct_product: WBCnstr00037750
    Microarray_results (18)
    Expression_cluster (136)
    Interaction (15)
  Map_info: Map: X Position: 14.3412 Error: 0.068825
    Positive: Positive_clone: C04A11 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4143
        4898
        5297
    Pseudo_map_position
  Reference (14)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene