ZK686.3 is orthologous to the putative tumor suppressor candidate 3 (TUSC3); TUSC3 is involved in plasma membrane magnesium ion transport; ZK686.3 is also orthologous to the S. cerevisiae dolichyl-diphosphooligosaccharide-protein glycotransferase gamma chain (34-kD) subunit, OST3.
Predicted to be involved in protein N-linked glycosylation via asparagine. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of oligosaccharyltransferase complex. Used to study bacterial infectious disease. Human ortholog(s) of this gene implicated in X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection, and neoplasia; autosomal recessive intellectual developmental disorder 7; and congenital disorder of glycosylation Icc. Is an ortholog of human MAGT1 (magnesium transporter 1) and TUSC3 (tumor suppressor candidate 3).