WormBase Tree Display for Gene: WBGene00003576
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WBGene00003576 | SMap | S_parent | Sequence | CHROMOSOME_IV | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||||
Name | CGC_name | ndc-80 | Person_evidence | WBPerson283 | |||||
Sequence_name | W01B6.9 | ||||||||
Molecular_name (3) | |||||||||
Other_name | cogc-7 | Paper_evidence | WBPaper00026979 | ||||||
Person_evidence | WBPerson449 | ||||||||
CELE_W01B6.9 | Accession_evidence | NDB | BX284604 | ||||||
Public_name | ndc-80 | ||||||||
DB_info | Database | AceView | gene | 4K851 | |||||
WormQTL | gene | WBGene00003576 | |||||||
WormFlux | gene | WBGene00003576 | |||||||
NDB | locus_tag | CELE_W01B6.9 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00003576|UniProtKB=Q17635 | |||||||
family | PTHR10643 | ||||||||
NCBI | gene | 177873 | |||||||
RefSeq | protein | NM_069429.5 | |||||||
SwissProt | UniProtAcc | Q17635 | |||||||
TREEFAM | TREEFAM_ID | TF101177 | |||||||
UniProt_GCRP | UniProtAcc | Q17635 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:32 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
2 | 16 Jan 2006 17:11:27 | WBPerson2970 | Name_change | Other_name | cogc-7 | ||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | ndc | ||||||||
Allele (30) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (38) | |||||||||
Ortholog (30) | |||||||||
Structured_description | Concise_description | ndc-80 (cogc-7) encodes an ortholog of mammalian COG-7 (OMIM:606978,mutated in congenital disorder of glycosylation), a subunit of lobe B ofthe conserved oligomeric Golgi complex (COGC); NDC-80 is also an outerkinetochore component orthologous to S. cerevisiae Ndc80p; NDC-80 affectsmetaphase plate formation in embryos (thus affecting chromosomesegregation), kinetochore-microtubule interactions, locomotion, vulvaldevelopment, body morphology, and embryonic viability; NDC-80 is weaklyrequired for normal gonadal distal tip cell migration, a process that alsorequires seven other orthologs of COGC subunits; like other lobe Bsubunits in both C. elegans and S. cerevisiae, NDC-80 is only partiallyrequired for normal function, while lobe A subunits are strongly requiredin either worms or yeast; NDC-80 interacts in vivo with KNL-1, HIM-10, anda homolog of Nuf2p, and NDC-80 and HIM-10 are codependent for kinetochoreassembly. | Paper_evidence | WBPaper00005330 | |||||
WBPaper00005654 | |||||||||
WBPaper00006142 | |||||||||
WBPaper00006309 | |||||||||
WBPaper00026979 | |||||||||
WBPaper00028363 | |||||||||
WBPaper00028599 | |||||||||
WBPaper00028601 | |||||||||
WBPaper00028602 | |||||||||
WBPaper00028603 | |||||||||
Curator_confirmed | WBPerson48 | ||||||||
WBPerson567 | |||||||||
Date_last_updated | 25 Oct 2006 00:00:00 | ||||||||
Automated_description | Enables protein domain specific binding activity. Involved in several processes, including chromosome organization; gonad morphogenesis; and positive regulation of kinetochore assembly. Located in kinetochore. Part of Ndc80 complex. Human ortholog(s) of this gene implicated in colorectal cancer; lung non-small cell carcinoma; and stomach cancer. Is an ortholog of human NDC80 (NDC80 kinetochore complex component). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16909) | ||||
DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16909) | ||||||
DOID:10534 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16909) | ||||||
Molecular_info | Corresponding_CDS | W01B6.9 | |||||||
Corresponding_transcript | W01B6.9.1 | ||||||||
Other_sequence | FG618964.1 | ||||||||
CR01998 | |||||||||
CBC04689_1 | |||||||||
CR03902 | |||||||||
CJC17913_1 | |||||||||
CRC01587_1 | |||||||||
CJC07860_1 | |||||||||
Associated_feature | WBsf646280 | ||||||||
WBsf660549 | |||||||||
WBsf228926 | |||||||||
WBsf228927 | |||||||||
WBsf228928 | |||||||||
Experimental_info | RNAi_result (17) | ||||||||
Expr_pattern | Expr3437 | ||||||||
Expr1017660 | |||||||||
Expr1031629 | |||||||||
Expr1158057 | |||||||||
Expr2013927 | |||||||||
Expr2032166 | |||||||||
Drives_construct | WBCnstr00018541 | ||||||||
WBCnstr00018542 | |||||||||
WBCnstr00018543 | |||||||||
WBCnstr00018544 | |||||||||
WBCnstr00018545 | |||||||||
WBCnstr00018553 | |||||||||
WBCnstr00036029 | |||||||||
Construct_product | WBCnstr00018541 | ||||||||
WBCnstr00018542 | |||||||||
WBCnstr00018543 | |||||||||
WBCnstr00018544 | |||||||||
WBCnstr00018545 | |||||||||
WBCnstr00018553 | |||||||||
WBCnstr00036029 | |||||||||
Antibody | WBAntibody00000992 | ||||||||
Microarray_results | SMD_C04G2.1 | ||||||||
SMD_W01B6.9 | |||||||||
177760_at | |||||||||
A_12_P108118 | |||||||||
A_12_P169519 | |||||||||
A_12_P169520 | |||||||||
Aff_W01B6.9 | |||||||||
GPL13394_WBGene00003576 | |||||||||
GPL13914_W01B6.9 | |||||||||
GPL14144_W01B6.9_1307-1366_0.938_4_A | |||||||||
GPL14144_W01B6.9_333-392_0.843_33_C | |||||||||
GPL14144_W01B6.9_416-475_0.863_21_B | |||||||||
GPL19516_CGZ0037793 | |||||||||
GPL21109_W01B6.9 | |||||||||
GPL3518_CE06537 | |||||||||
GPL8304_CE_WBGene00003576_A | |||||||||
GPL8304_CE_WBGene00003576_B | |||||||||
GPL8673_W01B6_9P00591 | |||||||||
GPL8673_W01B6_9P00832 | |||||||||
GPL8673_W01B6_9P01322 | |||||||||
GPL9450_W01B6.9 | |||||||||
cea2.p.99739 | |||||||||
Expression_cluster (160) | |||||||||
Interaction (97) | |||||||||
Map_info | Map | IV | Position | 4.49123 | Error | 0.003102 | |||
Positive | Positive_clone | W01B6 | Inferred_automatically | From CDS info | |||||
From sequence, transcript, pseudogene data | |||||||||
Pseudo_map_position | |||||||||
Reference (25) | |||||||||
Remark | Sequence connection from [Oegema K, Hyman AA] [090402 ck1] | ||||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
Method | Gene |