WormBase Tree Display for Gene: WBGene00000112

WBGene00000112 SMap: S_parent: Sequence: Y57G7A
  Identity (6)
  Gene_info: Biotype: SO:0001217
    Gene_class: alh
    Allele (200)
    RNASeq_FPKM (74)
    GO_annotation (14)
    Contained_in_operon: CEOP2044
    Ortholog (43)
    Paralog (11)
    Structured_description: Concise_description: alh-6 is orthologous to the human gene ALDEHYDE DEHYDROGENASE 4 FAMILY, MEMBER A1 (ALDH4A1; OMIM:606811), which when mutated leads to hyperprolinemia type II. Curator_confirmed: WBPerson1823
            WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable 1-pyrroline-5-carboxylate dehydrogenase activity. Predicted to be involved in proline catabolic process to glutamate. Predicted to be located in mitochondrial matrix. Expressed in head and tail. Human ortholog(s) of this gene implicated in hyperprolinemia type 2. Is an ortholog of human ALDH4A1 (aldehyde dehydrogenase 4 family member A1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0080543 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:406)
  Molecular_info: Corresponding_CDS: F56D12.1a
      F56D12.1b
      F56D12.1c
      F56D12.1d
    Corresponding_transcript: F56D12.1a.1
      F56D12.1a.2
      F56D12.1b.1
      F56D12.1c.1
      F56D12.1d.1
    Other_sequence (68)
    Associated_feature (11)
  Experimental_info: RNAi_result (13)
    Expr_pattern: Chronogram1568
      Expr6220
      Expr1014020
      Expr1030059
      Expr1152446
      Expr2009308
      Expr2027544
    Drives_construct: WBCnstr00002586
    Regulate_expr_cluster: WBPaper00059231:alh-6(lax105)_D3Adult_downregulated
      WBPaper00059231:alh-6(lax105)_D3Adult_upregulated
      WBPaper00059231:alh-6(lax105)_L4_downregulated
      WBPaper00059231:alh-6(lax105)_L4_upregulated
    Microarray_results: SMD_F56D12.1
      SMD_Y57G7A.10
      190694_s_at
      A_12_P101538
      A_12_P102437
      A_12_P149745
      A_12_P149746
      A_12_P149747
      A_12_P149748
      A_12_P149749
      GPL13394_WBGene00000112
      GPL13914_F56D12.1
      GPL14144_F56D12.1a_1066-1125_0.889_3_B
      GPL14144_F56D12.1a_1523-1582_0.906_1_A
      GPL14144_F56D12.1a_868-927_0.874_6_C
      GPL19516_CGZ0024594
      GPL19516_CGZ0024595
      GPL19516_CGZ0024596
      GPL19516_CGZ0024597
      GPL19516_CGZ0024598
      GPL19516_CGZ0024599
      GPL19516_CGZ0024600
      GPL19516_CGZ0024601
      GPL19516_CGZ0024602
      GPL19516_CGZ0024603
      GPL21109_F56D12.1a.1
      GPL21109_F56D12.1b.1
      GPL21109_F56D12.1b.2
      GPL3518_CE29047
      GPL8304_CE_WBGene00000112_A
      GPL8673_F56D12_1aP00401
      GPL8673_F56D12_1aP01162
      GPL8673_F56D12_1aP01607
      GPL8673_F56D12_1bP00401
      GPL8673_F56D12_1bP01162
      GPL8673_F56D12_1bP01389
      GPL8673_F56D12_1cP00401
      GPL8673_F56D12_1cP00663
      GPL8673_F56D12_1cP01124
      GPL8673_F56D12_1dP00742
      GPL8673_F56D12_1dP00966
      GPL8673_F56D12_1dP01187
      GPL9450_F56D12.1
      cea2.p.41234
    Expression_cluster (137)
    Interaction (68)
  Map_info: Map: II Position: -15.5079 Error: 0.004302
    Positive: Positive_clone: F56D12 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (15)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene