WormBase Tree Display for Gene: WBGene00004210
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WBGene00004210 | Evidence | CGC_data_submission | |||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | Y110A2AL | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | ptc | ||||||
Allele (195) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (14) | |||||||
Ortholog (41) | |||||||
Paralog (31) | |||||||
Structured_description | Concise_description | ptc-3 encodes an ortholog of Drosophila PATCHED (PTC) and human PTCH(OMIM:601309, mutated in basal cell nevus syndrome), which defines oneof seven paralogous families of sterol sensing domain (SSD) proteins;PTC-3 is strongly required for normal molting from L1 to L3 larvalstages; PTC-3 is also required for normal growth to full size and forviability. | Paper_evidence | WBPaper00004265 | |||
WBPaper00026841 | |||||||
WBPaper00027263 | |||||||
Curator_confirmed | WBPerson567 | ||||||
Date_last_updated | 08 Nov 2006 00:00:00 | ||||||
Automated_description | Predicted to enable hedgehog family protein binding activity; hedgehog receptor activity; and smoothened binding activity. Involved in molting cycle. Located in apical plasma membrane and cytoplasmic vesicle. Expressed in several structures, including CEP; cloaca; egg-laying apparatus; excretory duct; and preanal ganglion. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); colorectal adenoma; and holoprosencephaly 7. Is an ortholog of human PTCH1 (patched 1) and PTCH2 (patched 2). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:4195 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9585) | ||
DOID:2512 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9585) | ||||
DOID:0070365 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9585) | ||||
DOID:10534 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9585) | ||||
DOID:0050860 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9585) | ||||
DOID:0110876 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9585) | ||||
DOID:5522 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9585) | ||||
DOID:4948 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9585) | ||||
DOID:3910 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9585) | ||||
DOID:3748 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9585) | ||||
DOID:0050902 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9586) | ||||
DOID:10460 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9585) | ||||
DOID:2513 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9585,HGNC:9586) | ||||
DOID:1793 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9585) | ||||
DOID:0080016 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9585) | ||||
DOID:3907 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9585) | ||||
DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9585) | ||||
DOID:4621 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9585) | ||||
Molecular_info | Corresponding_CDS | Y110A2AL.8a | |||||
Y110A2AL.8b | |||||||
Y110A2AL.8c | |||||||
Corresponding_CDS_history | Y110A2AL.8a:wp127 | ||||||
Y110A2AL.8b:wp127 | |||||||
Corresponding_transcript | Y110A2AL.8a.1 | ||||||
Y110A2AL.8b.1 | |||||||
Y110A2AL.8c.1 | |||||||
Other_sequence (34) | |||||||
Associated_feature (13) | |||||||
Experimental_info | RNAi_result (14) | ||||||
Expr_pattern | Expr9231 | ||||||
Expr9232 | |||||||
Expr1017786 | |||||||
Expr1032067 | |||||||
Expr1158842 | |||||||
Expr2015145 | |||||||
Expr2033383 | |||||||
Drives_construct | WBCnstr00008494 | ||||||
WBCnstr00008496 | |||||||
WBCnstr00035634 | |||||||
Construct_product | WBCnstr00008494 | ||||||
WBCnstr00008495 | |||||||
WBCnstr00008496 | |||||||
WBCnstr00008497 | |||||||
WBCnstr00008498 | |||||||
WBCnstr00008502 | |||||||
WBCnstr00035634 | |||||||
Antibody | WBAntibody00002998 | ||||||
Microarray_results | SMD_Y110A2A_54.D | ||||||
SMD_Y110A2A_54.E | |||||||
SMD_Y110A2A_54.I | |||||||
187353_s_at | |||||||
A_12_P117808 | |||||||
A_12_P161578 | |||||||
A_12_P161579 | |||||||
A_12_P161580 | |||||||
Aff_Y110A2A_54.D | |||||||
Aff_Y110A2A_54.E | |||||||
GPL13394_WBGene00004210 | |||||||
GPL13914_Y110A2AL.8 | |||||||
GPL14144_Y110A2AL.8c_2887-2946_0.730_145_A | |||||||
GPL14144_Y110A2AL.8c_3356-3415_0.530_476_C | |||||||
GPL14144_Y110A2AL.8c_3507-3566_0.911_1_B | |||||||
GPL19516_CGZ0042156 | |||||||
GPL19516_CGZ0042157 | |||||||
GPL19516_CGZ0042158 | |||||||
GPL21109_Y110A2AL.8a | |||||||
GPL3518_CE29096 | |||||||
GPL8304_CE_WBGene00004210_A | |||||||
GPL8673_Y110A2AL_8aP02819 | |||||||
GPL8673_Y110A2AL_8aP02965 | |||||||
GPL8673_Y110A2AL_8aP03655 | |||||||
GPL8673_Y110A2AL_8bP02828 | |||||||
GPL8673_Y110A2AL_8bP02974 | |||||||
GPL8673_Y110A2AL_8bP03664 | |||||||
GPL9450_Y110A2AL.8a | |||||||
GPL9450_Y110A2AL.8b | |||||||
cea2.d.08081 | |||||||
cea2.d.42139 | |||||||
Expression_cluster (200) | |||||||
Interaction (78) | |||||||
WBProcess | WBbiopr:00000123 | ||||||
Map_info | Map | II | Position | -9.82406 | Error | 0.084736 | |
Positive | Positive_clone | Y110A2AL | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference (21) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |