WormBase Tree Display for Gene: WBGene00013866

WBGene00013866 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 2
    Name: CGC_name: cbs-1 Paper_evidence: WBPaper00039977
          Person_evidence: WBPerson537
      Sequence_name: ZC373.1
      Molecular_name: ZC373.1a
        ZC373.1a.1
        CE31670
        ZC373.1b
        CE47092
        ZC373.1b.1
      Other_name: CELE_ZC373.1 Accession_evidence: NDB BX284606
      Public_name: cbs-1
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:55 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 29 Sep 2011 10:45:56 WBPerson2970 Name_change: CGC_name: cbs-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cbs
    Allele (32)
    Strain: WBStrain00002826
      WBStrain00052082
    RNASeq_FPKM (74)
    GO_annotation (16)
    Ortholog (40)
    Paralog (12)
    Structured_description: Concise_description: cbs-1 encodes an ortholog of human CYSTATHIONINE-BETA-SYNTHASE (CBS), which when mutated leads to homocystinuria (OMIM:236200). Paper_evidence: WBPaper00004637
          Curator_confirmed: WBPerson1823
            WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables cystathionine beta-synthase activity; cysteine synthase activity; and pyridoxal phosphate binding activity. Involved in sulfur compound biosynthetic process. Located in cytoplasm. Expressed in pharyngeal muscle cell. Human ortholog(s) of this gene implicated in several diseases, including homocystinuria; hyperhomocysteinemia; and neural tube defect. Is an ortholog of human CBS (cystathionine beta-synthase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0080074 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1550)
      DOID:12365 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1550)
      DOID:9279 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1550)
      DOID:9263 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1550)
      DOID:3526 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1550)
      DOID:3393 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1550)
  Molecular_info: Corresponding_CDS: ZC373.1a
      ZC373.1b
    Corresponding_CDS_history: ZC373.1:wp83
    Corresponding_transcript: ZC373.1a.1
      ZC373.1b.1
    Other_sequence (40)
    Associated_feature: WBsf648441
      WBsf655205
      WBsf1006596
      WBsf236234
  Experimental_info: RNAi_result: WBRNAi00058845 Inferred_automatically: RNAi_primary
      WBRNAi00091457 Inferred_automatically: RNAi_primary
    Expr_pattern (8)
    Drives_construct: WBCnstr00003351
      WBCnstr00014401
      WBCnstr00029491
    Construct_product: WBCnstr00014401
      WBCnstr00016327
      WBCnstr00029491
    Antibody: WBAntibody00002306
    Microarray_results (22)
    Expression_cluster (173)
    Interaction: WBInteraction000045619
      WBInteraction000047726
      WBInteraction000049491
      WBInteraction000049615
      WBInteraction000113364
      WBInteraction000117577
      WBInteraction000119970
      WBInteraction000122936
      WBInteraction000123107
      WBInteraction000123408
      WBInteraction000123463
      WBInteraction000123466
      WBInteraction000136622
      WBInteraction000139616
      WBInteraction000139619
      WBInteraction000140173
      WBInteraction000141177
      WBInteraction000150443
      WBInteraction000160341
      WBInteraction000192811
      WBInteraction000202621
      WBInteraction000203431
      WBInteraction000210109
      WBInteraction000226680
      WBInteraction000234385
      WBInteraction000252229
      WBInteraction000257435
      WBInteraction000279011
      WBInteraction000280501
      WBInteraction000283155
      WBInteraction000288658
      WBInteraction000295047
      WBInteraction000305917
      WBInteraction000308211
      WBInteraction000313362
      WBInteraction000329334
      WBInteraction000353067
      WBInteraction000357404
      WBInteraction000367473
      WBInteraction000387827
      WBInteraction000388162
      WBInteraction000394509
      WBInteraction000414308
      WBInteraction000418733
      WBInteraction000418984
      WBInteraction000440195
      WBInteraction000450322
      WBInteraction000460019
      WBInteraction000465862
      WBInteraction000466318
      WBInteraction000467358
      WBInteraction000468394
      WBInteraction000468981
      WBInteraction000470689
      WBInteraction000470886
      WBInteraction000470888
      WBInteraction000471313
      WBInteraction000471316
      WBInteraction000474738
      WBInteraction000563163
      WBInteraction000570940
      WBInteraction000574308
      WBInteraction000574622
  Map_info: Map: X Position: 1.73547
    Positive: Positive_clone: ZC373 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00034443
    WBPaper00038491
    WBPaper00040475
    WBPaper00040626
    WBPaper00055090
    WBPaper00059856
    WBPaper00059949
    WBPaper00060431
    WBPaper00060693
    WBPaper00064989
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene