WormBase Tree Display for Gene: WBGene00004985

WBGene00004985 SMap: S_parent: Sequence: T05E11
  Identity: Version: 1
    Name: CGC_name: spo-11 Person_evidence: WBPerson1547
      Sequence_name: T05E11.4
      Molecular_name: T05E11.4a
        T05E11.4a.1
        CE06363
        T05E11.4b
        CE49824
        T05E11.4b.1
      Other_name: CELE_T05E11.4 Accession_evidence: NDB BX284604
      Public_name: spo-11
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:37 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: spo
    Allele (16)
    Legacy_information: [Dernburg AF] ok79 is 1227 bp deletion, presumed null. Homozygotes morphologically normal, Mel (>99%), Him, defective segregation of all chromosomes, meiotic exchange <1% of wildtype, normal synapsis of homologues. Encodes homologue of budding yeast Spo11p.
    Strain: WBStrain00034685
      WBStrain00035158
      WBStrain00035163
      WBStrain00035164
      WBStrain00000277
      WBStrain00000282
      WBStrain00007860
      WBStrain00047223
      WBStrain00047221
      WBStrain00047220
    RNASeq_FPKM (74)
    GO_annotation (23)
    Ortholog (36)
    Structured_description: Concise_description: spo-11 encodes an ortholog of Spo11p in S. cerevisiae that is required for meiotic DNA recombination, and (in conjunction with CHK-2 and MRE-11) for the localization of RAD-51 to foci in late zygotene/early pachytene nuclei; like its yeast ortholog, SPO-11 is related to a subunit of archaebacterial topoisomerase VI, and probably causes double-stranded DNA breaks through a topoisomerase-like transesterase mechanism; however, unlike Spo11p, SPO-11 is dispensable for homologous synapsis and formation of the synaptonemal complex; SPO-11 is active even in syp-1 mutants where its double-stranded breaks cannot be correctly processed; spo-11 is transcribed in the germline. Paper_evidence (5)
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable DNA binding activity. Involved in meiotic DNA double-strand break processing. Predicted to be located in nuclear chromosome. Is an ortholog of human SPO11 (SPO11 initiator of meiotic double strand breaks). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: T05E11.4a
      T05E11.4b
    Corresponding_transcript: T05E11.4a.1
      T05E11.4b.1
    Other_sequence: FD514501.1
      JI175391.1
      Dviv_isotig17985
      CSC00934_1
      Dviv_isotig17984
    Associated_feature: WBsf652193
      WBsf997770
      WBsf1018175
      WBsf230830
  Experimental_info: RNAi_result (23)
    Expr_pattern: Expr1027139
      Expr1032481
      Expr1156137
      Expr2016063
      Expr2034299
    Drives_construct: WBCnstr00035292
    Construct_product: WBCnstr00035292
    Microarray_results (19)
    Expression_cluster (117)
    Interaction: WBInteraction000001588
      WBInteraction000001815
      WBInteraction000002196
      WBInteraction000005237
      WBInteraction000009329
      WBInteraction000029560
      WBInteraction000031763
      WBInteraction000031764
      WBInteraction000032689
      WBInteraction000033806
      WBInteraction000033807
      WBInteraction000033808
      WBInteraction000048706
      WBInteraction000051533
      WBInteraction000051534
      WBInteraction000051535
      WBInteraction000051536
      WBInteraction000051717
      WBInteraction000052859
      WBInteraction000106272
      WBInteraction000109948
      WBInteraction000111316
      WBInteraction000111327
      WBInteraction000120375
      WBInteraction000121897
      WBInteraction000126509
      WBInteraction000126832
      WBInteraction000126833
      WBInteraction000140935
      WBInteraction000143700
      WBInteraction000145709
      WBInteraction000145895
      WBInteraction000145965
      WBInteraction000146943
      WBInteraction000149999
      WBInteraction000153192
      WBInteraction000160841
      WBInteraction000161558
      WBInteraction000164982
      WBInteraction000166333
      WBInteraction000168748
      WBInteraction000171435
      WBInteraction000171900
      WBInteraction000174952
      WBInteraction000175005
      WBInteraction000176511
      WBInteraction000176560
      WBInteraction000178320
      WBInteraction000180406
      WBInteraction000180528
      WBInteraction000182075
      WBInteraction000182890
      WBInteraction000185234
      WBInteraction000186926
      WBInteraction000187500
      WBInteraction000192012
      WBInteraction000192194
      WBInteraction000193508
      WBInteraction000194422
      WBInteraction000195011
      WBInteraction000195060
      WBInteraction000195298
      WBInteraction000196564
      WBInteraction000198450
      WBInteraction000198719
      WBInteraction000201746
      WBInteraction000204165
      WBInteraction000205331
      WBInteraction000206388
      WBInteraction000207015
      WBInteraction000207406
      WBInteraction000207680
      WBInteraction000207779
      WBInteraction000208433
      WBInteraction000208458
      WBInteraction000208712
      WBInteraction000208837
      WBInteraction000209244
      WBInteraction000210301
      WBInteraction000211308
      WBInteraction000211606
      WBInteraction000211935
      WBInteraction000212027
      WBInteraction000213566
      WBInteraction000214098
      WBInteraction000216360
      WBInteraction000218769
      WBInteraction000220623
      WBInteraction000222892
      WBInteraction000222945
      WBInteraction000225542
      WBInteraction000226147
      WBInteraction000227003
      WBInteraction000229703
      WBInteraction000230033
      WBInteraction000230273
      WBInteraction000230759
      WBInteraction000230982
      WBInteraction000231252
      WBInteraction000232279
      WBInteraction000233516
      WBInteraction000233927
      WBInteraction000234597
      WBInteraction000237695
      WBInteraction000239735
      WBInteraction000239981
      WBInteraction000239998
      WBInteraction000242237
      WBInteraction000244777
      WBInteraction000245145
      WBInteraction000245352
      WBInteraction000246225
      WBInteraction000247195
      WBInteraction000247653
      WBInteraction000247855
      WBInteraction000248381
      WBInteraction000249248
      WBInteraction000249521
      WBInteraction000250305
      WBInteraction000252856
      WBInteraction000253085
      WBInteraction000253390
      WBInteraction000254688
      WBInteraction000257319
      WBInteraction000257845
      WBInteraction000258011
      WBInteraction000258932
      WBInteraction000261064
      WBInteraction000262713
      WBInteraction000263201
      WBInteraction000263502
      WBInteraction000265075
      WBInteraction000265404
      WBInteraction000265543
      WBInteraction000265593
      WBInteraction000266475
      WBInteraction000268172
      WBInteraction000268665
      WBInteraction000269210
      WBInteraction000271596
      WBInteraction000272123
      WBInteraction000272564
      WBInteraction000275968
      WBInteraction000277996
      WBInteraction000279833
      WBInteraction000279915
      WBInteraction000280526
      WBInteraction000281128
      WBInteraction000284084
      WBInteraction000284483
      WBInteraction000285436
      WBInteraction000285635
      WBInteraction000286220
      WBInteraction000287105
      WBInteraction000288154
      WBInteraction000288589
      WBInteraction000290287
      WBInteraction000292330
      WBInteraction000292387
      WBInteraction000292450
      WBInteraction000293615
      WBInteraction000294083
      WBInteraction000294744
      WBInteraction000296088
      WBInteraction000296660
      WBInteraction000297016
      WBInteraction000297203
      WBInteraction000298960
      WBInteraction000301182
      WBInteraction000302736
      WBInteraction000303042
      WBInteraction000305130
      WBInteraction000308534
      WBInteraction000309356
      WBInteraction000310229
      WBInteraction000310511
      WBInteraction000316120
      WBInteraction000318444
      WBInteraction000318577
      WBInteraction000322815
      WBInteraction000322996
      WBInteraction000325847
      WBInteraction000326386
      WBInteraction000329059
      WBInteraction000330313
      WBInteraction000330660
      WBInteraction000330713
      WBInteraction000331623
      WBInteraction000333176
      WBInteraction000334432
      WBInteraction000334760
      WBInteraction000337670
      WBInteraction000343393
      WBInteraction000344606
      WBInteraction000345167
      WBInteraction000348335
      WBInteraction000349066
      WBInteraction000350231
      WBInteraction000353361
      WBInteraction000353469
      WBInteraction000353714
      WBInteraction000354043
      WBInteraction000354940
      WBInteraction000356998
      WBInteraction000357472
      WBInteraction000357781
      WBInteraction000358175
      WBInteraction000358583
      WBInteraction000360556
      WBInteraction000361455
      WBInteraction000362839
      WBInteraction000362871
      WBInteraction000363137
      WBInteraction000363659
      WBInteraction000363702
      WBInteraction000363775
      WBInteraction000364708
      WBInteraction000366889
      WBInteraction000369607
      WBInteraction000372133
      WBInteraction000375339
      WBInteraction000376691
      WBInteraction000377134
      WBInteraction000378439
      WBInteraction000379590
      WBInteraction000380089
      WBInteraction000380384
      WBInteraction000381136
      WBInteraction000381356
      WBInteraction000385365
      WBInteraction000385702
      WBInteraction000386193
      WBInteraction000386789
      WBInteraction000389222
      WBInteraction000391201
      WBInteraction000391597
      WBInteraction000392563
      WBInteraction000392681
      WBInteraction000394965
      WBInteraction000395172
      WBInteraction000396281
      WBInteraction000396347
      WBInteraction000396645
      WBInteraction000397585
      WBInteraction000397974
      WBInteraction000400563
      WBInteraction000401106
      WBInteraction000401654
      WBInteraction000403568
      WBInteraction000404640
      WBInteraction000405179
      WBInteraction000406111
      WBInteraction000407786
      WBInteraction000408069
      WBInteraction000408070
      WBInteraction000408071
      WBInteraction000408355
      WBInteraction000408416
      WBInteraction000409943
      WBInteraction000411723
      WBInteraction000414981
      WBInteraction000416429
      WBInteraction000417332
      WBInteraction000421171
      WBInteraction000425064
      WBInteraction000426947
      WBInteraction000430126
      WBInteraction000431051
      WBInteraction000431931
      WBInteraction000434929
      WBInteraction000435062
      WBInteraction000439158
      WBInteraction000446307
      WBInteraction000448266
      WBInteraction000448932
      WBInteraction000451960
      WBInteraction000454902
      WBInteraction000455087
      WBInteraction000457253
      WBInteraction000457340
      WBInteraction000464618
      WBInteraction000464619
      WBInteraction000465724
      WBInteraction000466871
      WBInteraction000469059
      WBInteraction000469150
      WBInteraction000472349
      WBInteraction000474481
      WBInteraction000474812
      WBInteraction000475057
      WBInteraction000501352
      WBInteraction000520837
      WBInteraction000557588
      WBInteraction000576823
      WBInteraction000576827
  Map_info: Map: IV Position: 4.89498 Error: 0.004494
    Well_ordered
    Positive: Positive_clone: T05E11 Person_evidence: WBPerson136
          Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4609
  Reference (133)
  Remark: Data extracted from Dernburg et al. (1998)
  Method: Gene