Enables protein phosphatase 2B binding activity and protein serine/threonine phosphatase inhibitor activity. Involved in several processes, including male mating behavior; positive regulation of nematode male tail tip morphogenesis; and thermosensory behavior. Predicted to be located in cytoplasm and nucleus. Expressed in several structures, including non-striated muscle; pharyngeal cell; somatic nervous system; tail; and vulva. Used to study Down syndrome. Human ortholog(s) of this gene implicated in Alzheimer's disease. Is an ortholog of human RCAN1 (regulator of calcineurin 1); RCAN2 (regulator of calcineurin 2); and RCAN3 (RCAN family member 3).
Inferred by orthology to human genes with DO annotation (HGNC:3040)
Disease_relevance
DSCR1) gene is located in the Down Syndrome critical region (DSCR) of chromosome 21, and encodes an inhibitor of calcineurin-signalling pathways; in elegans, overexpression of rcan-1 could reproduce calcineurin loss-of-function phenotypes, providing in vivo proof of rcan-1 regulation of calcineurin; also, as with mbk-1, another DSCR gene ortholog in elegans, adjusting rcan-1 dosage could reverse the effects of its overexpression.
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.