WormBase Tree Display for Gene: WBGene00004194

WBGene00004194 SMap: S_parent: Sequence: C34C6
  Identity: Version: 1
    Name (5)
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:34 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: prx
    Allele (30)
    Strain: WBStrain00026539
    RNASeq_FPKM (74)
    GO_annotation (13)
    Ortholog (42)
    Structured_description: Concise_description: prx-5 encodes an ortholog of the human receptor for type I peroxisomal targeting signal protein, PXR1 (or PEX5; OMIM:600414), which when mutated leads to neonatal adrenoleukodystrophy or Zellweger syndrome; PXR1 protein is a component of the peroxisomal import machinery known to exist in organisms like yeast, plants and mammals. Paper_evidence: WBPaper00004395
          Curator_confirmed: WBPerson1823
            WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables peroxisome targeting sequence binding activity. Involved in nematode larval development and protein import into peroxisome matrix. Predicted to be located in cytosol and peroxisomal membrane. Expressed in neurons. Human ortholog(s) of this gene implicated in peroxisome biogenesis disorder 2A; peroxisome biogenesis disorder 2B; and rhizomelic chondrodysplasia punctata type 5. Is an ortholog of human PEX5 (peroxisomal biogenesis factor 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0110854 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9719)
      DOID:0080622 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9719)
      DOID:0080477 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9719)
  Molecular_info: Corresponding_CDS: C34C6.6a
      C34C6.6b
    Corresponding_transcript: C34C6.6a.1
      C34C6.6b.1
    Other_sequence (27)
    Associated_feature: WBsf644497
      WBsf221804
  Experimental_info: RNAi_result (33)
    Expr_pattern: Expr11271
      Expr1023878
      Expr1032054
      Expr1145873
      Expr2015127
      Expr2033365
    Drives_construct: WBCnstr00018529
      WBCnstr00035645
      WBCnstr00038169
    Construct_product: WBCnstr00035645
      WBCnstr00038169
    Regulate_expr_cluster: WBPaper00060911:prx-5(RNAi)_downregulated_mRNA
      WBPaper00060911:prx-5(RNAi)_downregulated_protein
      WBPaper00060911:prx-5(RNAi)_upregulated_mRNA
      WBPaper00060911:prx-5(RNAi)_upregulated_protein
    Microarray_results (27)
    Expression_cluster (115)
    Interaction: WBInteraction000006515
      WBInteraction000006989
      WBInteraction000007030
      WBInteraction000007228
      WBInteraction000007367
      WBInteraction000007404
      WBInteraction000007449
      WBInteraction000007553
      WBInteraction000009428
      WBInteraction000028481
      WBInteraction000031283
      WBInteraction000031490
      WBInteraction000034188
      WBInteraction000037201
      WBInteraction000042154
      WBInteraction000042215
      WBInteraction000042221
      WBInteraction000047100
      WBInteraction000049398
      WBInteraction000049399
      WBInteraction000106326
      WBInteraction000114305
      WBInteraction000114306
      WBInteraction000114307
      WBInteraction000114308
      WBInteraction000119072
      WBInteraction000120030
      WBInteraction000121742
      WBInteraction000122489
      WBInteraction000133026
      WBInteraction000133033
      WBInteraction000133035
      WBInteraction000140276
      WBInteraction000145983
      WBInteraction000157056
      WBInteraction000160933
      WBInteraction000162970
      WBInteraction000167474
      WBInteraction000169599
      WBInteraction000169600
      WBInteraction000169601
      WBInteraction000178442
      WBInteraction000179710
      WBInteraction000185381
      WBInteraction000186591
      WBInteraction000195945
      WBInteraction000199370
      WBInteraction000203347
      WBInteraction000203655
      WBInteraction000207211
      WBInteraction000213486
      WBInteraction000214390
      WBInteraction000216982
      WBInteraction000218627
      WBInteraction000233791
      WBInteraction000252350
      WBInteraction000258697
      WBInteraction000268212
      WBInteraction000279653
      WBInteraction000292970
      WBInteraction000294169
      WBInteraction000315695
      WBInteraction000320637
      WBInteraction000339766
      WBInteraction000340812
      WBInteraction000340813
      WBInteraction000340814
      WBInteraction000340815
      WBInteraction000347174
      WBInteraction000351867
      WBInteraction000354685
      WBInteraction000359803
      WBInteraction000371044
      WBInteraction000375268
      WBInteraction000376088
      WBInteraction000384310
      WBInteraction000384311
      WBInteraction000384312
      WBInteraction000386004
      WBInteraction000387951
      WBInteraction000396114
      WBInteraction000398938
      WBInteraction000411318
      WBInteraction000412322
      WBInteraction000436768
      WBInteraction000443132
      WBInteraction000447232
      WBInteraction000460050
      WBInteraction000462394
      WBInteraction000463358
      WBInteraction000465359
      WBInteraction000466178
      WBInteraction000467694
      WBInteraction000471620
      WBInteraction000474919
      WBInteraction000505992
      WBInteraction000505993
      WBInteraction000505994
      WBInteraction000505995
      WBInteraction000505996
      WBInteraction000505998
      WBInteraction000505999
      WBInteraction000506001
      WBInteraction000506081
      WBInteraction000506082
      WBInteraction000506083
      WBInteraction000506084
      WBInteraction000506085
      WBInteraction000506088
      WBInteraction000506090
      WBInteraction000506092
      WBInteraction000506093
      WBInteraction000506094
      WBInteraction000506095
      WBInteraction000506096
      WBInteraction000506097
      WBInteraction000506140
      WBInteraction000506141
      WBInteraction000506142
      WBInteraction000506143
      WBInteraction000509777
      WBInteraction000509781
      WBInteraction000509800
      WBInteraction000511926
      WBInteraction000511927
      WBInteraction000511929
      WBInteraction000511930
      WBInteraction000511932
      WBInteraction000511935
      WBInteraction000511936
      WBInteraction000511937
      WBInteraction000511984
      WBInteraction000511985
      WBInteraction000521473
      WBInteraction000527145
      WBInteraction000527146
      WBInteraction000527147
      WBInteraction000527148
      WBInteraction000527149
      WBInteraction000527150
      WBInteraction000527151
      WBInteraction000527152
      WBInteraction000527153
      WBInteraction000527154
      WBInteraction000527155
      WBInteraction000527156
      WBInteraction000527157
      WBInteraction000529336
      WBInteraction000530575
      WBInteraction000534352
      WBInteraction000534412
      WBInteraction000534476
      WBInteraction000534697
      WBInteraction000535024
      WBInteraction000544234
      WBInteraction000544247
      WBInteraction000544550
      WBInteraction000544564
      WBInteraction000546284
      WBInteraction000547432
      WBInteraction000547433
      WBInteraction000547434
      WBInteraction000547435
      WBInteraction000556640
      WBInteraction000556700
  Map_info: Map: II Position: 0.849291 Error: 0.001325
    Positive: Positive_clone: C34C6 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (16)
  Remark: Sequence connection from [Motley AM, Plasterk RHA], 02/06/13 krb.
    Note that some Authors have incorrectly published prx genes as pex genes. pex genes are a separate class of gene not related to prx genes[JAH][030108 ck1]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene