WormBase Tree Display for Gene: WBGene00003964

WBGene00003964 SMap: S_parent: Sequence: H06O01
  Identity: Version: 1
    Name: CGC_name: pdi-3 Person_evidence: WBPerson466
      Sequence_name: H06O01.1
      Molecular_name: H06O01.1
        H06O01.1.1
        CE11570
        H06O01.1.2
      Other_name: CELE_H06O01.1 Accession_evidence: NDB BX284601
      Public_name: pdi-3
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:33 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: pdi
    Allele (54)
    Strain: WBStrain00047528
      WBStrain00055430
    RNASeq_FPKM (74)
    GO_annotation (22)
    Ortholog (38)
    Paralog (13)
    Structured_description: Concise_description: pdi-3 encodes a protein disulfide isomerase (PDI) required for normal cuticle collagen deposition and, subliminally, for maintenance of normal body shape; PDI-3 has both PDI and calcium-dependent transglutaminase activity in vitro, crosslinking proteins through a gamma-glutamyl epsilon-lysine dual residue; PDI-3 is homologous to the human PDI ERp60, as well as a homolog in the dog heartworm Dirofilaria immitis that is required for larval molting; the joint PDI/transglutaminase activity of PDI-3 is biochemically conserved in nematodes and mammals; pdi-3 is constitutively and broadly expressed, particularly in gut and hypodermis. Paper_evidence (8)
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables protein disulfide isomerase activity and protein-glutamine gamma-glutamyltransferase activity. Involved in several processes, including collagen and cuticulin-based cuticle development; egg-laying behavior; and male anatomical structure morphogenesis. Predicted to be located in endoplasmic reticulum. Expressed in hypodermis; intestine; and seam cell. Human ortholog(s) of this gene implicated in autoimmune hepatitis and liver cirrhosis. Is an ortholog of human PDIA3 (protein disulfide isomerase family A member 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:2048 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4606)
      DOID:5082 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4606)
  Molecular_info: Corresponding_CDS: H06O01.1
    Corresponding_transcript: H06O01.1.1
      H06O01.1.2
    Other_sequence (166)
    Associated_feature (15)
  Experimental_info: RNAi_result (22)
    Expr_pattern: Expr2298
      Expr2299
      Expr2350
      Expr2351
      Expr2352
      Expr1024250
      Expr1031888
      Expr1153069
      Expr2014807
      Expr2033041
    Drives_construct: WBCnstr00010756
      WBCnstr00010786
      WBCnstr00035769
    Construct_product: WBCnstr00010756
      WBCnstr00010786
      WBCnstr00035769
    Antibody: WBAntibody00000601
    Microarray_results (22)
    Expression_cluster (165)
    Interaction: WBInteraction000030391
      WBInteraction000031489
      WBInteraction000034914
      WBInteraction000035344
      WBInteraction000035346
      WBInteraction000046880
      WBInteraction000052755
      WBInteraction000140895
      WBInteraction000142588
      WBInteraction000147238
      WBInteraction000149469
      WBInteraction000151330
      WBInteraction000159792
      WBInteraction000160281
      WBInteraction000161838
      WBInteraction000162444
      WBInteraction000162445
      WBInteraction000165272
      WBInteraction000172532
      WBInteraction000174799
      WBInteraction000175964
      WBInteraction000181081
      WBInteraction000181272
      WBInteraction000195789
      WBInteraction000196274
      WBInteraction000196961
      WBInteraction000209190
      WBInteraction000209842
      WBInteraction000214269
      WBInteraction000225207
      WBInteraction000235653
      WBInteraction000250739
      WBInteraction000251395
      WBInteraction000254644
      WBInteraction000255433
      WBInteraction000267384
      WBInteraction000270767
      WBInteraction000272888
      WBInteraction000278265
      WBInteraction000279154
      WBInteraction000286352
      WBInteraction000286649
      WBInteraction000288380
      WBInteraction000296029
      WBInteraction000301603
      WBInteraction000318632
      WBInteraction000322498
      WBInteraction000325630
      WBInteraction000326260
      WBInteraction000328773
      WBInteraction000339370
      WBInteraction000343815
      WBInteraction000369331
      WBInteraction000374862
      WBInteraction000375432
      WBInteraction000377839
      WBInteraction000385855
      WBInteraction000386297
      WBInteraction000402883
      WBInteraction000403451
      WBInteraction000407449
      WBInteraction000414548
      WBInteraction000417126
      WBInteraction000428101
      WBInteraction000428443
      WBInteraction000430194
      WBInteraction000431677
      WBInteraction000437366
      WBInteraction000443204
      WBInteraction000458632
      WBInteraction000462045
      WBInteraction000502983
      WBInteraction000536823
      WBInteraction000540929
      WBInteraction000549642
      WBInteraction000552802
      WBInteraction000554599
      WBInteraction000555139
      WBInteraction000555363
      WBInteraction000561784
      WBInteraction000562128
      WBInteraction000568580
      WBInteraction000568626
      WBInteraction000572321
      WBInteraction000572687
      WBInteraction000573501
      WBInteraction000577674
      WBInteraction000578952
      WBInteraction000584551
    WBProcess: WBbiopr:00000124
  Map_info: Map: I Position: 1.65339 Error: 0.000736
    Positive: Positive_clone: H06O01 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (22)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene