[Chin G, Villeneuve AM] me41 homozyotes are viable hermaphrodite, morphologically normal;98% of eggs fail to hatch, Him: 24% of viable progeny are male. Defective in meiotic recombination and chiasma formation, radiation-induced chromosome damage, but not in DNA-damage-induced apoptosis. ok179 similar. Encoding ortholog of budding yeast Mre11p
mre-11 encodes a protein orthologous to S. cerevisiae MRE11 and to human MRE11A (OMIM:600814, mutated in ataxia-telangiectasia-like disorder); MRE-11 is required for meiotic recombination and DNA repair in C. elegans, for multigenerational persistence of the germline, and (in conjunction with CHK-2 and SPO-11) for the localization of RAD-51 to foci in late zygotene/early pachytene nuclei.
Predicted to enable single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in DNA damage response and nucleic acid metabolic process. Located in nucleus. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Lynch syndrome; endometrial cancer; and gastrointestinal system cancer (multiple). Is an ortholog of human MRE11 (MRE11 homolog, double strand break repair nuclease).