WormBase Tree Display for Gene: WBGene00001591
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WBGene00001591 | SMap | S_parent | Sequence | F11A5 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | glc-1 | Person_evidence | WBPerson32 | |||||
Sequence_name | F11A5.10 | ||||||||
Molecular_name | F11A5.10 | ||||||||
F11A5.10.1 | |||||||||
CE24896 | |||||||||
Other_name | GluCl alpha | Paper_evidence | WBPaper00005494 | ||||||
WBPaper00044702 | |||||||||
CELE_F11A5.10 | Accession_evidence | NDB | BX284605 | ||||||
Public_name | glc-1 | ||||||||
DB_info | Database | AceView | gene | 5Q701 | |||||
WormQTL | gene | WBGene00001591 | |||||||
WormFlux | gene | WBGene00001591 | |||||||
NDB | locus_tag | CELE_F11A5.10 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00001591|UniProtKB=G5EBR3 | |||||||
family | PTHR18945 | ||||||||
NCBI | gene | 180086 | |||||||
RefSeq | protein | NM_074689.7 | |||||||
SwissProt | UniProtAcc | G5EBR3 | |||||||
UniProt_GCRP | UniProtAcc | G5EBR3 | |||||||
OMIM | gene | 138491 | |||||||
138492 | |||||||||
305990 | |||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | glc | ||||||||
Allele (121) | |||||||||
Strain (12) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (32) | |||||||||
Ortholog (38) | |||||||||
Paralog (101) | |||||||||
Structured_description | Concise_description | glc-1 encodes the alpha subunit of a glutamate-gated chloride channel and forms a functional channel in Xenopus oocytes; mutations genetically interact with avr-14 and avr-15 mutations such that triple mutants exhibit high level resistance to ivermectin. | Paper_evidence | WBPaper00002049 | |||||
WBPaper00003319 | |||||||||
WBPaper00003954 | |||||||||
Curator_confirmed | WBPerson48 | ||||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
Automated_description | Enables extracellularly glutamate-gated chloride channel activity; glutamate binding activity; and identical protein binding activity. Involved in chloride transmembrane transport; locomotion involved in locomotory behavior; and protein complex oligomerization. Located in plasma membrane. Expressed in body wall musculature; head neurons; and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in hyperekplexia 1; hyperekplexia 2; and syndromic X-linked intellectual disability Pilorge type. Is an ortholog of human GLRA2 (glycine receptor alpha 2) and GLRA3 (glycine receptor alpha 3). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:0070422 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4327) | ||||
DOID:0060696 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4326) | ||||||
DOID:0060697 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4329) | ||||||
Molecular_info | Corresponding_CDS | F11A5.10 | |||||||
Corresponding_transcript | F11A5.10.1 | ||||||||
Other_sequence (15) | |||||||||
Associated_feature | WBsf647623 | ||||||||
WBsf233084 | |||||||||
Experimental_info | RNAi_result | WBRNAi00044346 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00103267 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00085188 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00103268 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00030804 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00066347 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00085186 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00085187 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00013102 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00085184 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern | Expr9953 | ||||||||
Expr1021950 | |||||||||
Expr1148282 | |||||||||
Expr2012079 | |||||||||
Expr2030315 | |||||||||
Drives_construct | WBCnstr00009990 | ||||||||
WBCnstr00009991 | |||||||||
WBCnstr00009992 | |||||||||
WBCnstr00009993 | |||||||||
WBCnstr00009994 | |||||||||
WBCnstr00009995 | |||||||||
WBCnstr00009996 | |||||||||
WBCnstr00014965 | |||||||||
WBCnstr00036841 | |||||||||
Construct_product (9) | |||||||||
Microarray_results (20) | |||||||||
Expression_cluster (239) | |||||||||
Interaction | WBInteraction000114256 | ||||||||
WBInteraction000121220 | |||||||||
WBInteraction000122545 | |||||||||
WBInteraction000122666 | |||||||||
WBInteraction000122667 | |||||||||
WBInteraction000153249 | |||||||||
WBInteraction000189199 | |||||||||
WBInteraction000197107 | |||||||||
WBInteraction000201634 | |||||||||
WBInteraction000224132 | |||||||||
WBInteraction000235122 | |||||||||
WBInteraction000237208 | |||||||||
WBInteraction000240967 | |||||||||
WBInteraction000246260 | |||||||||
WBInteraction000247462 | |||||||||
WBInteraction000248670 | |||||||||
WBInteraction000249464 | |||||||||
WBInteraction000250276 | |||||||||
WBInteraction000265662 | |||||||||
WBInteraction000267952 | |||||||||
WBInteraction000269113 | |||||||||
WBInteraction000270553 | |||||||||
WBInteraction000287695 | |||||||||
WBInteraction000288676 | |||||||||
WBInteraction000289782 | |||||||||
WBInteraction000297283 | |||||||||
WBInteraction000300042 | |||||||||
WBInteraction000303161 | |||||||||
WBInteraction000309768 | |||||||||
WBInteraction000310047 | |||||||||
WBInteraction000311880 | |||||||||
WBInteraction000315096 | |||||||||
WBInteraction000321575 | |||||||||
WBInteraction000324176 | |||||||||
WBInteraction000325957 | |||||||||
WBInteraction000327707 | |||||||||
WBInteraction000332245 | |||||||||
WBInteraction000333394 | |||||||||
WBInteraction000334723 | |||||||||
WBInteraction000336185 | |||||||||
WBInteraction000344226 | |||||||||
WBInteraction000349180 | |||||||||
WBInteraction000350531 | |||||||||
WBInteraction000358062 | |||||||||
WBInteraction000360876 | |||||||||
WBInteraction000364410 | |||||||||
WBInteraction000365343 | |||||||||
WBInteraction000365570 | |||||||||
WBInteraction000372814 | |||||||||
WBInteraction000383659 | |||||||||
WBInteraction000388870 | |||||||||
WBInteraction000399677 | |||||||||
WBInteraction000411523 | |||||||||
WBInteraction000412937 | |||||||||
WBInteraction000420595 | |||||||||
WBInteraction000422018 | |||||||||
WBInteraction000422058 | |||||||||
WBInteraction000424782 | |||||||||
WBInteraction000426551 | |||||||||
WBInteraction000433574 | |||||||||
WBInteraction000435920 | |||||||||
WBInteraction000440721 | |||||||||
WBInteraction000441119 | |||||||||
WBInteraction000454251 | |||||||||
WBInteraction000500425 | |||||||||
WBInteraction000500426 | |||||||||
WBInteraction000542995 | |||||||||
WBInteraction000543016 | |||||||||
WBInteraction000543124 | |||||||||
WBInteraction000543616 | |||||||||
WBInteraction000557982 | |||||||||
WBInteraction000557983 | |||||||||
WBInteraction000580010 | |||||||||
Map_info | Map | V | Position | 9.84523 | Error | 0.001681 | |||
Positive | Positive_clone | F11A5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Pseudo_map_position | |||||||||
Reference (32) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |