WormBase Tree Display for Gene: WBGene00006948

WBGene00006948 SMap: S_parent: Sequence: F52E4
  Identity: Version: 1
    Name: CGC_name: wrt-2 Person_evidence: WBPerson83
      Sequence_name: F52E4.6
      Molecular_name: F52E4.6
        F52E4.6.1
        CE07273
      Other_name: CELE_F52E4.6 Accession_evidence: NDB BX284606
      Public_name: wrt-2
    DB_info: Database: AceView gene XD712
        WormQTL gene WBGene00006948
        WormFlux gene WBGene00006948
        NDB locus_tag CELE_F52E4.6
        Panther gene CAEEL|WormBase=WBGene00006948|UniProtKB=Q20677
          family PTHR46706
        NCBI gene 180597
        RefSeq protein NM_076128.7
        TREEFAM TREEFAM_ID TF316084
        TrEMBL UniProtAcc Q20677
        UniProt_GCRP UniProtAcc Q20677
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:43 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: wrt
    Allele (28)
    Strain: WBStrain00007244
      WBStrain00007245
      WBStrain00007246
      WBStrain00007914
      WBStrain00032807
    RNASeq_FPKM (74)
    Ortholog (23)
    Paralog (24)
    Structured_description: Concise_description: wrt-2 encodes a hedgehog-like protein, with an N-terminal signalsequence, a Wart domain, and a C-terminal region of low-complexitysequence; WRT-2 is expressed in seam cells and hypodermal syncytia; theWart domain is predicted to form a cysteine-crosslinked protein involvedin intercellular signalling, and it has subtle similarity to theN-terminal Hedge domain of HEDGEHOG proteins; WRT-2 is weakly requiredfor normal molting; WRT-2 is also required for normal growth to fullsize and locomotion; all of these requirements may reflect commondefects in cholesterol-dependent hedgehog-like signalling or in vesicletrafficking; in two-hybrid assays, WRT-2 binds EYA-1, which may parallelthe derepression of Drosophila eyes absent by HEDGEHOG. Paper_evidence: WBPaper00003717
            WBPaper00006332
            WBPaper00026841
            WBPaper00027263
            WBPaper00027697
          Curator_confirmed: WBPerson567
          Date_last_updated: 05 Nov 2006 00:00:00
      Automated_description: Expressed in hypodermal cell and hypodermis. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F52E4.6
    Corresponding_transcript: F52E4.6.1
    Other_sequence (41)
    Associated_feature: WBsf653804
      WBsf653805
      WBsf1022564
      WBsf1022565
      WBsf1022566
      WBsf237135
      WBsf237136
  Experimental_info: RNAi_result: WBRNAi00077008 Inferred_automatically: RNAi_primary
      WBRNAi00047999 Inferred_automatically: RNAi_primary
      WBRNAi00076981 Inferred_automatically: RNAi_primary
      WBRNAi00015424 Inferred_automatically: RNAi_primary
      WBRNAi00032625 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr642
      Expr13913
      Expr1027232
      Expr1032962
      Expr1151814
      Expr2018077
      Expr2036215
    Drives_construct (22)
    Construct_product: WBCnstr00034080
    Microarray_results (18)
    Expression_cluster (251)
    Interaction: WBInteraction000030502
      WBInteraction000103097
      WBInteraction000112001
      WBInteraction000112430
      WBInteraction000118042
      WBInteraction000118486
      WBInteraction000121443
      WBInteraction000127456
      WBInteraction000134439
      WBInteraction000137308
      WBInteraction000137401
      WBInteraction000141284
      WBInteraction000144546
      WBInteraction000144943
      WBInteraction000146373
      WBInteraction000159654
      WBInteraction000160602
      WBInteraction000163471
      WBInteraction000168874
      WBInteraction000182084
      WBInteraction000182998
      WBInteraction000185953
      WBInteraction000187720
      WBInteraction000188155
      WBInteraction000189800
      WBInteraction000191002
      WBInteraction000192153
      WBInteraction000193309
      WBInteraction000193531
      WBInteraction000194260
      WBInteraction000194704
      WBInteraction000196813
      WBInteraction000198818
      WBInteraction000200289
      WBInteraction000200688
      WBInteraction000200947
      WBInteraction000204974
      WBInteraction000215494
      WBInteraction000215759
      WBInteraction000219205
      WBInteraction000219935
      WBInteraction000225631
      WBInteraction000227998
      WBInteraction000229216
      WBInteraction000229611
      WBInteraction000230629
      WBInteraction000233611
      WBInteraction000240640
      WBInteraction000246482
      WBInteraction000246900
      WBInteraction000249074
      WBInteraction000251060
      WBInteraction000257666
      WBInteraction000258887
      WBInteraction000260832
      WBInteraction000266034
      WBInteraction000266627
      WBInteraction000272178
      WBInteraction000272413
      WBInteraction000277243
      WBInteraction000281423
      WBInteraction000283339
      WBInteraction000287971
      WBInteraction000290420
      WBInteraction000290447
      WBInteraction000306632
      WBInteraction000307571
      WBInteraction000308331
      WBInteraction000311728
      WBInteraction000312750
      WBInteraction000313778
      WBInteraction000314017
      WBInteraction000323752
      WBInteraction000326334
      WBInteraction000328347
      WBInteraction000333780
      WBInteraction000341803
      WBInteraction000342133
      WBInteraction000342487
      WBInteraction000344454
      WBInteraction000364694
      WBInteraction000365589
      WBInteraction000367298
      WBInteraction000369384
      WBInteraction000372676
      WBInteraction000379907
      WBInteraction000391153
      WBInteraction000397982
      WBInteraction000408843
      WBInteraction000414928
      WBInteraction000427737
      WBInteraction000432005
      WBInteraction000440524
      WBInteraction000441526
      WBInteraction000443440
      WBInteraction000445019
      WBInteraction000455384
      WBInteraction000461027
      WBInteraction000502393
      WBInteraction000544371
      WBInteraction000581377
    WBProcess: WBbiopr:00000123
  Map_info: Map: X Position: -12.232 Error: 0.019344
    Positive: Positive_clone: F52E4 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00002823
    WBPaper00003717
    WBPaper00011801
    WBPaper00024393
    WBPaper00026841
    WBPaper00027697
    WBPaper00028754
    WBPaper00031588
    WBPaper00032049
    WBPaper00038491
    WBPaper00055389
    WBPaper00061387
    WBPaper00064105
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene