WormBase Tree Display for Gene: WBGene00003421

WBGene00003421 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: F09E8
  Identity: Version: 1
    Name: CGC_name: msh-5 Person_evidence: WBPerson1547
      Sequence_name: F09E8.3
      Molecular_name: F09E8.3a
        F09E8.3a.1
        CE26678
        F09E8.3b
        CE49987
        F09E8.3b.1
      Other_name: CELE_F09E8.3 Accession_evidence: NDB BX284604
      Public_name: msh-5
    DB_info: Database: AceView gene 4N927
        WormQTL gene WBGene00003421
        WormFlux gene WBGene00003421
        NDB locus_tag CELE_F09E8.3
        Panther gene CAEEL|WormBase=WBGene00003421|UniProtKB=Q19272
          family PTHR11361
        NCBI gene 178268
        RefSeq protein NM_001380506.1
            NM_070130.8
        SwissProt UniProtAcc Q19272
        UniProt_GCRP UniProtAcc Q19272
        OMIM gene 603382
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:31 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: msh
    Allele (169)
    Legacy_information: [Kelly KO, Villeneuve AM ] me23 homozygotes viable hermaphrodite, morphologically normal; 98% of eggs fail to hatch, Him: 42% of viable progeny are male. me45 similar. Cloned: F09E8.3, homologous to budding yeast MSH5.
    Strain: WBStrain00000279
    RNASeq_FPKM (74)
    GO_annotation (20)
    Ortholog (36)
    Paralog: WBGene00001872 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003418 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003422 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: msh-5 encodes a germline-specific homolog of the yeast and mammalian DNA mismatch repair protein MSH5 (MutS-family) that is required for crossing over and chiasma formation during Caenorhabditis elegans meiosis; inactivation of both rad-51 and msh-5 induces chromosome fragmentation, not seen with inactivation of either gene alone. Paper_evidence: WBPaper00004377
            WBPaper00004424
            WBPaper00005134
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable double-stranded DNA binding activity. Involved in chiasma assembly. Located in nucleus. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; primary ovarian insufficiency 13; and spermatogenic failure. Is an ortholog of human MSH5 (mutS homolog 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0111910 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7328)
      DOID:3908 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7328)
      DOID:0080870 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7328)
  Molecular_info: Corresponding_CDS: F09E8.3a
      F09E8.3b
    Corresponding_CDS_history: F09E8.3:wp37
    Corresponding_transcript: F09E8.3a.1
      F09E8.3b.1
    Other_sequence: AF070070
      TMC02651_1
      JI167893.1
      BXC01774_1
      TM03704
    Associated_feature: WBsf1018496
      WBsf229395
  Experimental_info: RNAi_result: WBRNAi00030712 Inferred_automatically: RNAi_primary
      WBRNAi00001814 Inferred_automatically: RNAi_primary
      WBRNAi00012983 Inferred_automatically: RNAi_primary
      WBRNAi00012984 Inferred_automatically: RNAi_primary
      WBRNAi00008131 Inferred_automatically: RNAi_primary
      WBRNAi00044136 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr10004
      Expr1027885
      Expr1031586
      Expr1148104
      Expr2013767
      Expr2032002
    Drives_construct: WBCnstr00036128
    Construct_product: WBCnstr00036128
    Antibody: WBAntibody00002196
      WBAntibody00003031
    Microarray_results (25)
    Expression_cluster (147)
    Interaction: WBInteraction000008604
      WBInteraction000034088
      WBInteraction000034881
      WBInteraction000036452
      WBInteraction000051720
      WBInteraction000102243
      WBInteraction000102942
      WBInteraction000110354
      WBInteraction000110711
      WBInteraction000126893
      WBInteraction000134673
      WBInteraction000136893
      WBInteraction000136918
      WBInteraction000147207
      WBInteraction000149930
      WBInteraction000153192
      WBInteraction000170204
      WBInteraction000196523
      WBInteraction000198280
      WBInteraction000205108
      WBInteraction000206724
      WBInteraction000212428
      WBInteraction000214006
      WBInteraction000217708
      WBInteraction000218765
      WBInteraction000219040
      WBInteraction000219495
      WBInteraction000222339
      WBInteraction000225069
      WBInteraction000227384
      WBInteraction000238455
      WBInteraction000241951
      WBInteraction000244573
      WBInteraction000249870
      WBInteraction000255348
      WBInteraction000265152
      WBInteraction000271455
      WBInteraction000295764
      WBInteraction000303928
      WBInteraction000310981
      WBInteraction000312573
      WBInteraction000318681
      WBInteraction000320910
      WBInteraction000338222
      WBInteraction000340315
      WBInteraction000353761
      WBInteraction000372734
      WBInteraction000392502
      WBInteraction000396637
      WBInteraction000410484
      WBInteraction000414096
      WBInteraction000414097
      WBInteraction000432788
      WBInteraction000442155
      WBInteraction000442757
      WBInteraction000443603
      WBInteraction000448693
      WBInteraction000451215
      WBInteraction000463217
      WBInteraction000466206
      WBInteraction000469179
      WBInteraction000473770
      WBInteraction000474565
      WBInteraction000475252
      WBInteraction000502318
      WBInteraction000504400
      WBInteraction000519965
      WBInteraction000556030
      WBInteraction000556105
      WBInteraction000556106
      WBInteraction000559815
      WBInteraction000559817
      WBInteraction000559819
  Map_info: Map: IV Position: 8.22608 Error: 0.01548
    Well_ordered
    Positive: Positive_clone: F09E8 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4008
        4009
  Reference: WBPaper00003240
    WBPaper00004198
    WBPaper00004349
    WBPaper00004377
    WBPaper00005134
    WBPaper00005486
    WBPaper00006010
    WBPaper00006086
    WBPaper00017535
    WBPaper00018081
    WBPaper00018747
    WBPaper00022284
    WBPaper00024115
    WBPaper00026369
    WBPaper00027086
    WBPaper00027223
    WBPaper00027700
    WBPaper00027942
    WBPaper00027974
    WBPaper00027996
    WBPaper00031432
    WBPaper00031940
    WBPaper00032296
    WBPaper00034425
    WBPaper00035505
    WBPaper00036364
    WBPaper00038491
    WBPaper00039364
    WBPaper00042568
    WBPaper00048543
    WBPaper00052023
    WBPaper00055090
    WBPaper00055518
    WBPaper00055541
    WBPaper00058643
    WBPaper00061204
    WBPaper00063133
    WBPaper00063963
    WBPaper00064114
    WBPaper00064168
    WBPaper00064957
  Remark: sequence connection from [Villeneuve AM]
    Sequence connection from [Boulton S, Vidal M]
    Data extracted from Kelly et al. (2000)
    F09E8.2 removed. email from JAH 0109
    Positive_clone is based on mutant sequence [030403 ck1]
  Method: Gene