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WormBase Tree Display for Gene: WBGene00006950

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Name Class

WBGene00006950EvidencePaper_evidenceWBPaper00003717
SMapS_parentSequenceZK678
IdentityVersion1
NameCGC_namewrt-4Person_evidenceWBPerson83
Sequence_nameZK678.5
Molecular_nameZK678.5
ZK678.5.1
CE24735
Other_nameZK678Paper_evidenceWBPaper00002823
CELE_ZK678.5Accession_evidenceNDBBX284606
Public_namewrt-4
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:43WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classwrt
Allele (95)
RNASeq_FPKM (74)
GO_annotation (21)
Ortholog (38)
Paralog (24)
Structured_descriptionConcise_descriptionwrt-4 encodes a hedgehog-like protein, with (from N- to C-terminus) asignal sequence, a Wart domain, an short region of low-complexitysequence, and a Hint/Hog domain; WRT-4 is expressed strongly inhypodermal syncytia hyp6-hyp10 from 3-fold embryos to adults; theHint/Hog domain is predicted to cut WRT-4 into two halves and thencovalently link cholesterol to the C-terminus of the Wart domain; theWart domain is predicted to form a cysteine-crosslinked protein involvedin intercellular signalling, and it has subtle similarity to theN-terminal Hedge domain of HEDGEHOG proteins; WRT-4 is weakly requiredfor normal molting; WRT-4 is also required for normal adult alaeformation, growth to full size, locomotion, and male tail development;all of these requirements may reflect common defects incholesterol-dependent hedgehog-like signalling or in vesicletrafficking.Paper_evidenceWBPaper00003717
WBPaper00026841
WBPaper00027263
Curator_confirmedWBPerson567
Date_last_updated05 Nov 2006 00:00:00
Automated_descriptionPredicted to enable peptidase activity. Acts upstream of or within nematode male tail mating organ morphogenesis. Predicted to be located in cell surface; extracellular region; and plasma membrane. Expressed in hyp10; hyp6; hyp7 syncytium; hyp8; and hyp9. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; gastrointestinal system cancer (multiple); and glomerulonephritis (multiple). Is an ortholog of human SHH (sonic hedgehog signaling molecule).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0111380Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10848)
DOID:9256Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10848)
DOID:1148Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10848)
EFO:MONDO:0000170Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10848)
DOID:0050784Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10848)
DOID:0060041Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10848)
DOID:10534Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10848)
DOID:13608Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10848)
DOID:2986Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10848)
DOID:1312Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10848)
DOID:2377Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10848)
DOID:10976Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10848)
EFO:MONDO:0017425Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10848)
DOID:9253Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10848)
DOID:0111818Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10848)
DOID:2513Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10848)
DOID:0110875Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10848)
DOID:10487Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10848)
DOID:0111564Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10848)
DOID:3328Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10848)
DOID:4621Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10848)
DOID:3525Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10848)
Molecular_infoCorresponding_CDSZK678.5
Corresponding_transcriptZK678.5.1
Other_sequenceCR07553
CRC07527_1
Associated_featureWBsf654671
WBsf671393
WBsf671394
WBsf671395
WBsf1008328
WBsf238350
WBsf238351
Experimental_infoRNAi_resultWBRNAi00022124Inferred_automaticallyRNAi_primary
WBRNAi00089223Inferred_automaticallyRNAi_primary
WBRNAi00001249Inferred_automaticallyRNAi_primary
WBRNAi00076983Inferred_automaticallyRNAi_primary
WBRNAi00027686Inferred_automaticallyRNAi_primary
WBRNAi00076976Inferred_automaticallyRNAi_primary
WBRNAi00059657Inferred_automaticallyRNAi_primary
WBRNAi00077010Inferred_automaticallyRNAi_primary
Expr_patternExpr644
Expr1011469
Expr1032963
Expr1163068
Expr2018079
Expr2036217
Drives_constructWBCnstr00012469
WBCnstr00034078
Construct_productWBCnstr00034078
Microarray_results (19)
Expression_cluster (266)
InteractionWBInteraction000110256
WBInteraction000111242
WBInteraction000114606
WBInteraction000114612
WBInteraction000114616
WBInteraction000121859
WBInteraction000122116
WBInteraction000124427
WBInteraction000125120
WBInteraction000127128
WBInteraction000127293
WBInteraction000133424
WBInteraction000133762
WBInteraction000134343
WBInteraction000136690
WBInteraction000138498
WBInteraction000138854
WBInteraction000139001
WBInteraction000139501
WBInteraction000144372
WBInteraction000144401
WBInteraction000144534
WBInteraction000144979
WBInteraction000145193
WBInteraction000145790
WBInteraction000146874
WBInteraction000147843
WBInteraction000149779
WBInteraction000150083
WBInteraction000150939
WBInteraction000152685
WBInteraction000153280
WBInteraction000157295
WBInteraction000157619
WBInteraction000159954
WBInteraction000160629
WBInteraction000160714
WBInteraction000161096
WBInteraction000162817
WBInteraction000163410
WBInteraction000164321
WBInteraction000164564
WBInteraction000165414
WBInteraction000168513
WBInteraction000171989
WBInteraction000171994
WBInteraction000173623
WBInteraction000175943
WBInteraction000177051
WBInteraction000177148
WBInteraction000177377
WBInteraction000177444
WBInteraction000177658
WBInteraction000178343
WBInteraction000180277
WBInteraction000181331
WBInteraction000184193
WBInteraction000184618
WBInteraction000185897
WBInteraction000188326
WBInteraction000188359
WBInteraction000189479
WBInteraction000190248
WBInteraction000191749
WBInteraction000193952
WBInteraction000193958
WBInteraction000195142
WBInteraction000196491
WBInteraction000196715
WBInteraction000199286
WBInteraction000200797
WBInteraction000201327
WBInteraction000201370
WBInteraction000202192
WBInteraction000203015
WBInteraction000204370
WBInteraction000205242
WBInteraction000206658
WBInteraction000207110
WBInteraction000207253
WBInteraction000207375
WBInteraction000208511
WBInteraction000209598
WBInteraction000210860
WBInteraction000211271
WBInteraction000211687
WBInteraction000213904
WBInteraction000214226
WBInteraction000214692
WBInteraction000214909
WBInteraction000215435
WBInteraction000219380
WBInteraction000219569
WBInteraction000219604
WBInteraction000222305
WBInteraction000225331
WBInteraction000225987
WBInteraction000226321
WBInteraction000229392
WBInteraction000230767
WBInteraction000233456
WBInteraction000234703
WBInteraction000234858
WBInteraction000237216
WBInteraction000237362
WBInteraction000238188
WBInteraction000239956
WBInteraction000242460
WBInteraction000242520
WBInteraction000243063
WBInteraction000245913
WBInteraction000249787
WBInteraction000250800
WBInteraction000254001
WBInteraction000256599
WBInteraction000260449
WBInteraction000260906
WBInteraction000261304
WBInteraction000272552
WBInteraction000273675
WBInteraction000278726
WBInteraction000289864
WBInteraction000289939
WBInteraction000290445
WBInteraction000291244
WBInteraction000293172
WBInteraction000293782
WBInteraction000296172
WBInteraction000296551
WBInteraction000297153
WBInteraction000302292
WBInteraction000303853
WBInteraction000305047
WBInteraction000305535
WBInteraction000308371
WBInteraction000309060
WBInteraction000311286
WBInteraction000312607
WBInteraction000313943
WBInteraction000317022
WBInteraction000318954
WBInteraction000319997
WBInteraction000320207
WBInteraction000321411
WBInteraction000328970
WBInteraction000331909
WBInteraction000334438
WBInteraction000336123
WBInteraction000339026
WBInteraction000342640
WBInteraction000344896
WBInteraction000352595
WBInteraction000353328
WBInteraction000353499
WBInteraction000355962
WBInteraction000356909
WBInteraction000357836
WBInteraction000358223
WBInteraction000359407
WBInteraction000359506
WBInteraction000362495
WBInteraction000366751
WBInteraction000367500
WBInteraction000378652
WBInteraction000382578
WBInteraction000391564
WBInteraction000392573
WBInteraction000402226
WBInteraction000406218
WBInteraction000407944
WBInteraction000412838
WBInteraction000417786
WBInteraction000418359
WBInteraction000418367
WBInteraction000423676
WBInteraction000427063
WBInteraction000429113
WBInteraction000431054
WBInteraction000441760
WBInteraction000451969
WBInteraction000455817
WBInteraction000458900
WBInteraction000548480
WBProcessWBbiopr:00000123
Map_infoMapXPosition22.9576Error0.001831
PositivePositive_cloneZK678Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point5265
5356
Pseudo_map_position
Reference (11)
Remarkcm02c8, yk175d1 yk105d8 cDNAs removed from sequence list above now canonical one added. sdm 11/00
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene