pfd-5 encodes a putative prefoldin 5 subunit, orthologous to human PFDN5 (OMIM:604899), that is required for normal microtubule growth, embryonic and larval viability, fertility, vulval development, and locomotion; PFD-5 is expressed in most, if not all, tissues; pfd-5(RNAi) animals show sterile progeny, larval arrest or lethality, uncoordination, and abnormal body shapes, and pfd-5(RNAi) embryos show a reduced microtubule growth rate.
Predicted to enable unfolded protein binding activity. Predicted to be involved in RNA polymerase I assembly; RNA polymerase II core complex assembly; and RNA polymerase III assembly. Predicted to be located in cytoplasm. Predicted to be part of prefoldin complex. Expressed in body wall musculature; head muscle; pharyngeal muscle cell; and vulval muscle. Is an ortholog of human PFDN5 (prefoldin subunit 5).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.
CGC_data_submission
[200811 gw3] Modified Map position as it was a reverse physical that could not be fixed by automated methods. (-0.772512)
[200811 gw3] Modified Map position as it was a reverse physical that could not be fixed by automated methods. (-0.769642)