WormBase Tree Display for Gene: WBGene00006778
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| WBGene00006778 | SMap | S_parent | Sequence | CHROMOSOME_V | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-42 | Person_evidence | WBPerson261 | |||||
| Sequence_name | F58E6.10 | ||||||||
| Molecular_name (15) | |||||||||
| Other_name | CELE_F58E6.10 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | unc-42 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00143077 | ||||||||
| Allele (90) | |||||||||
| Possibly_affected_by | WBVar02154108 | ||||||||
| Legacy_information | e270 : medium kinker tends to back when touched on tail slightly small fairly active grows well Egl-c. ES3 ME1. Similar phenotypes in e270/Df. NA3 (e419 e623). | ||||||||
| See also e2325 | |||||||||
| [C.elegansII] e270 : medium kinker, sometimes backs in response to tail touch, slightly small, fairly active, grows well; Egl-c; HSN fasciculation abnormal. ES3 ME1. Similar phenotypes in e270/Df. OA>5: e419, e623, e2325, s260, m435, etc. [Brenner 1974; NG] | |||||||||
| Strain (72) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (29) | |||||||||
| Ortholog (41) | |||||||||
| Paralog (20) | |||||||||
| Structured_description | Concise_description | unc-42 encodes a paired-like homeodomain protein of the Q50 class; UNC-42 is required to specify the fate of ASH sensory neurons, AVA, AVD, and AVE interneurons, and a subset of motor neurons; unc-42 mutants fail to express cell-surface receptors required for differentiated neuronal function (sra-6, srb-6, glr-1, glr-5, and glr-6); UNC-42 is also required for AVKR and HSNL growth cones to follow the PVPR and PVQL pioneer axons, for axonal outgrowth in the backward command interneurons AVA, AVD, and AVE, and for inhibition of ectopic FMRFamide-positive and GABAergic axons; unc-42 mutants are defective in mechanosensation, backward motion, and regulation of egg-laying. | Paper_evidence | WBPaper00002837 | |||||
| WBPaper00003555 | |||||||||
| WBPaper00004567 | |||||||||
| WBPaper00012756 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including larval locomotory behavior; neuron differentiation; and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in hypodermis; nerve ring; and neurons. Human ortholog(s) of this gene implicated in hypogonadism and panhypopituitarism. Is an ortholog of several human genes including ESX1 (ESX homeobox 1); PROP1 (PROP paired-like homeobox 1); and RHOXF2 (Rhox homeobox family member 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9406 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9455) | ||||
| DOID:1924 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9455) | ||||||
| DOID:9410 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9455) | ||||||
| Molecular_info | Corresponding_CDS | F58E6.10a | |||||||
| F58E6.10b | |||||||||
| F58E6.10c | |||||||||
| F58E6.10d | |||||||||
| F58E6.10e | |||||||||
| Corresponding_CDS_history | F58E6.10:wp123 | ||||||||
| F58E6.10:wp149 | |||||||||
| Corresponding_transcript | F58E6.10a.1 | ||||||||
| F58E6.10b.1 | |||||||||
| F58E6.10c.1 | |||||||||
| F58E6.10d.1 | |||||||||
| F58E6.10e.1 | |||||||||
| Other_sequence (20) | |||||||||
| Associated_feature (17) | |||||||||
| Transcription_factor | WBTranscriptionFactor000603 | ||||||||
| Experimental_info | RNAi_result (13) | ||||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00006353 | ||||||||
| WBCnstr00006841 | |||||||||
| WBCnstr00010221 | |||||||||
| WBCnstr00012736 | |||||||||
| WBCnstr00015693 | |||||||||
| WBCnstr00034157 | |||||||||
| Construct_product (3) | |||||||||
| Antibody (2) | |||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (166) | |||||||||
| Interaction (241) | |||||||||
| Map_info | Map | V | Position | 2.1654 | Error | 0.007367 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | eDf1 | |||||||
| sDf29 | |||||||||
| nDf31 | |||||||||
| ctDp11 | |||||||||
| Positive_clone | F58E6 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Negative | Outside_rearr | nDf1 | |||||||
| nDf42 | |||||||||
| Mapping_data | 2_point (27) | ||||||||
| Multi_point (175) | |||||||||
| Pos_neg_data | 306 | ||||||||
| 858 | |||||||||
| 864 | |||||||||
| 1738 | |||||||||
| 1764 | |||||||||
| 1779 | |||||||||
| 1810 | |||||||||
| 2171 | |||||||||
| 9123 | |||||||||
| Landmark_gene | |||||||||
| Reference (108) | |||||||||
| Method | Gene |
