WormBase Tree Display for Gene: WBGene00004740
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WBGene00004740 | SMap | S_parent | Sequence | T10H9 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | scd | ||||||
Allele (110) | |||||||
Legacy_information | [Inoue T] suppressor of daf-14 | ||||||
[M Ailion] insensitive to dauer pheromone | |||||||
Complementation_data | [M Ailion] sa935 complements let-410(s815), let-469(s1582) and let-472(s1605) | ||||||
Strain | WBStrain00003301 | ||||||
WBStrain00022788 | |||||||
WBStrain00022842 | |||||||
WBStrain00022843 | |||||||
WBStrain00031496 | |||||||
WBStrain00035143 | |||||||
WBStrain00035146 | |||||||
WBStrain00037657 | |||||||
WBStrain00040849 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (25) | |||||||
Ortholog (37) | |||||||
Paralog (34) | |||||||
Structured_description | Concise_description | scd-2 encodes the homolog of the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase (RTK) (OMIM:105590, involved in the development of non-Hodgkin's lymphoma in humans); the ALK family of receptor tyrosine kinases belong to the insulin receptor superfamily; scd-2 was initially identified in a naturally occuring desert oasis strain of C. elegans that fails to respond to the dauer pheromone at 25 degrees centigrade, but does so at a higher temperature; genetic interactions of scd-2 with several genes in the TGF-beta pathway including daf-7, daf-8 and daf-4 indicate that scd-2 acts in parallel to or converges with this pathway to regulate dauer formation via activation of the daf-3 transcription factor; further, genetic interaction studies indicate that the genes hen-1 (ortholog of the ALK ligand), soc-1 (RTK multi-adaptor protein related to DOS/Gab) and sma-5 (similar to human ERK5/MAP kinase 7) act along with scd-2 RTK in a chemosensory transduction pathway that converges with the TGF-beta pathway to affect the dauer decision. | Paper_evidence | WBPaper00032073 | |||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 17 Sep 2008 00:00:00 | ||||||
Automated_description | Predicted to enable ATP binding activity and transmembrane receptor protein tyrosine kinase activity. Involved in dauer larval development; sensory perception of chemical stimulus; and sensory processing. Predicted to be located in plasma membrane. Expressed in AIAL; AIAR; NSML; and NSMR. Is an ortholog of human ALK (ALK receptor tyrosine kinase) and LTK (leukocyte receptor tyrosine kinase). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | T10H9.2 | |||||
Corresponding_CDS_history | T10H9.2:wp121 | ||||||
T10H9.2:wp220 | |||||||
Corresponding_transcript | T10H9.2.1 | ||||||
Associated_feature | WBsf1000317 | ||||||
WBsf1000318 | |||||||
WBsf1019832 | |||||||
WBsf1019833 | |||||||
WBsf231896 | |||||||
Experimental_info | RNAi_result | WBRNAi00068033 | Inferred_automatically | RNAi_primary | |||
WBRNAi00018573 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00067479 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00098142 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00002394 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00053087 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00053086 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Chronogram196 | ||||||
Expr6667 | |||||||
Expr9242 | |||||||
Expr11450 | |||||||
Expr1015343 | |||||||
Expr1032340 | |||||||
Expr1156693 | |||||||
Expr2015624 | |||||||
Expr2033859 | |||||||
Drives_construct | WBCnstr00000607 | ||||||
WBCnstr00003772 | |||||||
WBCnstr00013848 | |||||||
WBCnstr00035417 | |||||||
Construct_product | WBCnstr00000607 | ||||||
WBCnstr00005348 | |||||||
WBCnstr00013848 | |||||||
WBCnstr00016490 | |||||||
WBCnstr00018853 | |||||||
WBCnstr00035417 | |||||||
Microarray_results (20) | |||||||
Expression_cluster (179) | |||||||
Interaction (30) | |||||||
Map_info | Map | V | Position | 0.130833 | Error | 0.001507 | |
Well_ordered | |||||||
Positive | Positive_clone | F44C4 | Author_evidence | Ailion EMM | |||
T10H9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Negative | Negative_clone | ZK1055 | Author_evidence | Ailion EMM | |||
Mapping_data | 2_point | 7101 | |||||
7107 | |||||||
Multi_point | 3813 | ||||||
3814 | |||||||
3863 | |||||||
3866 | |||||||
3867 | |||||||
3868 | |||||||
3869 | |||||||
4598 | |||||||
Pos_neg_data | 10611 | ||||||
10612 | |||||||
Reference (30) | |||||||
Remark | sa935 is an allele found in wild isolate CB4507 | ||||||
Method | Gene |