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WormBase Tree Display for Gene: WBGene00004740

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Name Class

WBGene00004740SMapS_parentSequenceT10H9
Identity (6)
Gene_infoBiotypeSO:0001217
Gene_classscd
Allele (110)
Legacy_information[Inoue T] suppressor of daf-14
[M Ailion] insensitive to dauer pheromone
Complementation_data[M Ailion] sa935 complements let-410(s815), let-469(s1582) and let-472(s1605)
StrainWBStrain00003301
WBStrain00022788
WBStrain00022842
WBStrain00022843
WBStrain00031496
WBStrain00035143
WBStrain00035146
WBStrain00037657
WBStrain00040849
RNASeq_FPKM (74)
GO_annotation (25)
Ortholog (37)
Paralog (34)
Structured_descriptionConcise_descriptionscd-2 encodes the homolog of the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase (RTK) (OMIM:105590, involved in the development of non-Hodgkin's lymphoma in humans); the ALK family of receptor tyrosine kinases belong to the insulin receptor superfamily; scd-2 was initially identified in a naturally occuring desert oasis strain of C. elegans that fails to respond to the dauer pheromone at 25 degrees centigrade, but does so at a higher temperature; genetic interactions of scd-2 with several genes in the TGF-beta pathway including daf-7, daf-8 and daf-4 indicate that scd-2 acts in parallel to or converges with this pathway to regulate dauer formation via activation of the daf-3 transcription factor; further, genetic interaction studies indicate that the genes hen-1 (ortholog of the ALK ligand), soc-1 (RTK multi-adaptor protein related to DOS/Gab) and sma-5 (similar to human ERK5/MAP kinase 7) act along with scd-2 RTK in a chemosensory transduction pathway that converges with the TGF-beta pathway to affect the dauer decision.Paper_evidenceWBPaper00032073
Curator_confirmedWBPerson324
Date_last_updated17 Sep 2008 00:00:00
Automated_descriptionPredicted to enable ATP binding activity and transmembrane receptor protein tyrosine kinase activity. Involved in dauer larval development; sensory perception of chemical stimulus; and sensory processing. Predicted to be located in plasma membrane. Expressed in AIAL; AIAR; NSML; and NSMR. Is an ortholog of human ALK (ALK receptor tyrosine kinase) and LTK (leukocyte receptor tyrosine kinase).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDST10H9.2
Corresponding_CDS_historyT10H9.2:wp121
T10H9.2:wp220
Corresponding_transcriptT10H9.2.1
Associated_featureWBsf1000317
WBsf1000318
WBsf1019832
WBsf1019833
WBsf231896
Experimental_infoRNAi_resultWBRNAi00068033Inferred_automaticallyRNAi_primary
WBRNAi00018573Inferred_automaticallyRNAi_primary
WBRNAi00067479Inferred_automaticallyRNAi_primary
WBRNAi00098142Inferred_automaticallyRNAi_primary
WBRNAi00002394Inferred_automaticallyRNAi_primary
WBRNAi00053087Inferred_automaticallyRNAi_primary
WBRNAi00053086Inferred_automaticallyRNAi_primary
Expr_patternChronogram196
Expr6667
Expr9242
Expr11450
Expr1015343
Expr1032340
Expr1156693
Expr2015624
Expr2033859
Drives_constructWBCnstr00000607
WBCnstr00003772
WBCnstr00013848
WBCnstr00035417
Construct_productWBCnstr00000607
WBCnstr00005348
WBCnstr00013848
WBCnstr00016490
WBCnstr00018853
WBCnstr00035417
Microarray_results (20)
Expression_cluster (179)
Interaction (30)
Map_infoMapVPosition0.130833Error0.001507
Well_ordered
PositivePositive_cloneF44C4Author_evidenceAilion EMM
T10H9Inferred_automaticallyFrom sequence, transcript, pseudogene data
NegativeNegative_cloneZK1055Author_evidenceAilion EMM
Mapping_data2_point7101
7107
Multi_point3813
3814
3863
3866
3867
3868
3869
4598
Pos_neg_data10611
10612
Reference (30)
Remarksa935 is an allele found in wild isolate CB4507
MethodGene