WormBase Tree Display for Gene: WBGene00004297
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| WBGene00004297 | Evidence | Paper_evidence | WBPaper00003305 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | Y43C5A | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | rad-51 | |||||||
| Sequence_name | Y43C5A.6 | ||||||||
| Molecular_name | Y43C5A.6a | ||||||||
| Y43C5A.6a.1 | |||||||||
| CE29064 | |||||||||
| Y43C5A.6b | |||||||||
| CE25285 | |||||||||
| Y43C5A.6c | |||||||||
| CE48196 | |||||||||
| Y43C5A.6b.1 | |||||||||
| Y43C5A.6c.1 | |||||||||
| Other_name (3) | |||||||||
| Public_name | rad-51 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | rad | ||||||||
| Allele (46) | |||||||||
| Possibly_affected_by | WBVar02152822 | ||||||||
| Legacy_information | [Higashitani A] A homolog of RAD51,DMC1/LIM15,eukaryotic recA-like gene.egg lethal: block chromosome condensation of six bivalents and not proceed to diakinesis in oocytes by RNAi. | ||||||||
| Strain | WBStrain00034660 | ||||||||
| WBStrain00034661 | |||||||||
| WBStrain00036936 | |||||||||
| WBStrain00004049 | |||||||||
| WBStrain00034464 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (55) | |||||||||
| Contained_in_operon | CEOP4368 | ||||||||
| Ortholog (41) | |||||||||
| Paralog | WBGene00004342 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| Structured_description | Concise_description | rad-51 encodes two isoforms of a protein orthologous to S. cerevisiae Rad51p and Dmc1p, and to E. coli RecA, and paralogous to C30A5.2; RAD-51 proteins are probably required for meiotic recombination; while dispensable for viability and meiotic synapsis, RAD-51A/B are required for normal chromosomal morphology, univalent formation, dissociation of chiasmata, hyperresistance of meiotic pachytene nuclei to X-irradiation, and the progress of oocytes through diakinesis; RAD-51A/B require CHK-2, MRE-11, and SPO-11 to localize to foci in late zygotene/early pachytene nuclei, and genetically acts downstream of CHK-2 and SPO-11; RAD-51A/B foci later disappear from homologously synapsed chromosomes. | Paper_evidence | WBPaper00003305 | |||||
| WBPaper00003358 | |||||||||
| WBPaper00004413 | |||||||||
| WBPaper00005784 | |||||||||
| WBPaper00006010 | |||||||||
| WBPaper00005134 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 30 Jan 2014 00:00:00 | ||||||||
| Automated_description | Enables several functions, including ATP hydrolysis activity; DEAD/H-box RNA helicase binding activity; and catalytic activity, acting on DNA. Involved in several processes, including intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; meiotic chromosome condensation; and negative regulation of apoptotic process. Located in condensed nuclear chromosome; germ cell nucleus; and site of double-strand break. Expressed in gonad. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia complementation group R; congenital mirror movement disorder; and ovary epithelial cancer. Is an ortholog of human RAD51 (RAD51 recombinase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0111153 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9817) | ||||
| DOID:2152 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9817) | ||||||
| DOID:0111090 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9817) | ||||||
| DOID:2394 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9817) | ||||||
| DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9817) | ||||||
| Molecular_info | Corresponding_CDS | Y43C5A.6a | |||||||
| Y43C5A.6b | |||||||||
| Y43C5A.6c | |||||||||
| Corresponding_CDS_history | Y43C5A.6:wp62 | ||||||||
| Corresponding_transcript | Y43C5A.6a.1 | ||||||||
| Y43C5A.6b.1 | |||||||||
| Y43C5A.6c.1 | |||||||||
| Other_sequence (34) | |||||||||
| Associated_feature | WBsf652121 | ||||||||
| WBsf997586 | |||||||||
| WBsf1018066 | |||||||||
| WBsf230710 | |||||||||
| Experimental_info | RNAi_result (55) | ||||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00035583 | ||||||||
| Construct_product | WBCnstr00035583 | ||||||||
| Antibody (22) | |||||||||
| Microarray_results (25) | |||||||||
| Expression_cluster (141) | |||||||||
| Interaction (301) | |||||||||
| Map_info | Map | IV | Position | 4.56693 | Error | 0.001237 | |||
| Positive | Positive_clone | Y43C5A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4603 | |||||||
| 4622 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (187) | |||||||||
| Remark | La Volpe et al. has also independently termed this gene as Ce-rad-51. | ||||||||
| No evidence here in db for links to DDBJ:AB011382 and H36F17. sdm 11/00 | |||||||||
| BUT H36F17 overlaps Y43C5A, so removing H36F17 sequence connection. sdm 12/00 | |||||||||
| Sequence connection from [Boulton S, Vidal M] | |||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
