WormBase Tree Display for Gene: WBGene00002694
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| WBGene00002694 | SMap | S_parent | Sequence | C10H11 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | let-502 | Person_evidence | WBPerson533 | |||||
| Sequence_name | C10H11.9 | ||||||||
| Molecular_name | C10H11.9 | ||||||||
| C10H11.9.1 | |||||||||
| CE08098 | |||||||||
| Other_name | let-531 | Person_evidence | WBPerson533 | ||||||
| CELE_C10H11.9 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | let-502 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:29 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 05 Mar 2015 11:30:22 | WBPerson2970 | Event | Acquires_merge | WBGene00002722 | ||||
| Name_change | Other_name | let-531 | |||||||
| Acquires_merge | WBGene00002722 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | let | ||||||||
| Allele (86) | |||||||||
| Legacy_information | [Howell AM] lethal | ||||||||
| [C.elegansII] h392 : mid larval lethal. OA5:h783 (late larval lethal), h509 (sterile adult), ca201sd (embryonic arrest, early morphogenesis; ca201/+ sometimes abnormal), h732, h835(both mid-larval lethal).All alleles probable dominant negatives. Cloned : encodes protein with similarity to human mytotonic dystrophy kinase. [Howell and Rose 1990; HR; JM; KR] | |||||||||
| [McDowall JS] lethal | |||||||||
| [McDowall JS] Late larval lethal | |||||||||
| [C.elegansII] h733 : late larval lethal. OA1: h767. [KR] | |||||||||
| Strain | WBStrain00001788 | ||||||||
| WBStrain00001510 | |||||||||
| WBStrain00023777 | |||||||||
| WBStrain00023857 | |||||||||
| WBStrain00031978 | |||||||||
| WBStrain00040423 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (43) | |||||||||
| Contained_in_operon | CEOP1780 | ||||||||
| Ortholog (44) | |||||||||
| Paralog | WBGene00019087 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WBGene00012198 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00006437 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | let-502 encodes a Rho-binding Ser/Thr kinase orthologous to human myotonic dystrophy kinase (DM-kinase); let-502 is required for early embryonic cleavages, embryonic elongation, migration of hypodermal P cells to a ventral position, normal spermathecal contraction, and fertility; LET-502 is required for hypodermal cells to properly change their shape, and is expressed in those cells, during embryonic elongation; let-502 mutations are suppressed by mel-11 mutations, and the pattern of LET-502 expression in the embryonic epidermis and the spermatheca is opposite to that of MEL-11, indicating that LET-502 and MEL-11 have opposing functions (presumably tissue contraction and relaxation); MEL-11 requires LET-502 (along with the nonmuscle myosin NMY-1) for proper localization. | Paper_evidence | WBPaper00002726 | |||||
| WBPaper00003517 | |||||||||
| WBPaper00004448 | |||||||||
| WBPaper00004959 | |||||||||
| WBPaper00005318 | |||||||||
| WBPaper00006149 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable Rho-dependent protein serine/threonine kinase activity. Involved in several processes, including embryonic body morphogenesis; nematode larval development; and pharyngeal gland morphogenesis. Located in adherens junction; contractile fiber; and nucleus. Expressed in several structures, including P3.p hermaphrodite; Z2; Z3; gonad; and hypodermis. Is an ortholog of human ROCK1 (Rho associated coiled-coil containing protein kinase 1) and ROCK2 (Rho associated coiled-coil containing protein kinase 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C10H11.9 | |||||||
| Corresponding_transcript | C10H11.9.1 | ||||||||
| Other_sequence (30) | |||||||||
| Associated_feature | WBsf983475 | ||||||||
| WBsf1009697 | |||||||||
| WBsf219317 | |||||||||
| WBsf219318 | |||||||||
| WBsf219319 | |||||||||
| Experimental_info | RNAi_result (62) | ||||||||
| Expr_pattern (17) | |||||||||
| Drives_construct | WBCnstr00002367 | ||||||||
| WBCnstr00004324 | |||||||||
| WBCnstr00010340 | |||||||||
| WBCnstr00015095 | |||||||||
| WBCnstr00036323 | |||||||||
| Construct_product | WBCnstr00012483 | ||||||||
| WBCnstr00012484 | |||||||||
| WBCnstr00015095 | |||||||||
| WBCnstr00016492 | |||||||||
| WBCnstr00036323 | |||||||||
| WBCnstr00041691 | |||||||||
| WBCnstr00042164 | |||||||||
| Antibody | WBAntibody00000525 | ||||||||
| WBAntibody00002980 | |||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (110) | |||||||||
| Interaction (164) | |||||||||
| Map_info | Map | I | Position | -0.750734 | Error | 0.004963 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | gaDp1 | |||||||
| Positive_clone | C10H11 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| K06G1 | |||||||||
| Negative | Negative_clone | C07F10 | |||||||
| C12H4 | Author_evidence | McDowall JS | |||||||
| M01A12 | |||||||||
| Mapping_data | Multi_point | 3534 | |||||||
| 3535 | |||||||||
| 4424 | |||||||||
| 4936 | |||||||||
| Pos_neg_data (7) | |||||||||
| Reference (123) | |||||||||
| Remark | [McDowall JS] Extrachromosomal arrays containing three cosmids generated, then manipulated genetically. | ||||||||
| Method | Gene |
