WormBase Tree Display for Gene: WBGene00001745
expand all nodes | collapse all nodes | view schema
| WBGene00001745 | SMap | S_parent | Sequence | R06A10 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | gsa-1 | Person_evidence | WBPerson459 | |||||
| Sequence_name | R06A10.2 | ||||||||
| Molecular_name | R06A10.2a | ||||||||
| R06A10.2a.1 | |||||||||
| CE47896 | |||||||||
| R06A10.2b | |||||||||
| CE49189 | |||||||||
| R06A10.2b.1 | |||||||||
| Other_name | CELE_R06A10.2 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | gsa-1 | ||||||||
| DB_info | Database | AceView | gene | 1B547 | |||||
| WormQTL | gene | WBGene00001745 | |||||||
| WormFlux | gene | WBGene00001745 | |||||||
| NDB | locus_tag | CELE_R06A10.2 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00001745|UniProtKB=Q7KPV0 | |||||||
| family | PTHR10218 | ||||||||
| NCBI | gene | 171687 | |||||||
| RefSeq | protein | NM_001380932.1 | |||||||
| NM_001380927.2 | |||||||||
| TrEMBL | UniProtAcc | Q7KPV0 | |||||||
| V6CL61 | |||||||||
| UniProt_GCRP | UniProtAcc | Q7KPV0 | |||||||
| OMIM | gene | 139312 | |||||||
| 139320 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | gsa | ||||||||
| Laboratory | NL | ||||||||
| Reference_allele | WBVar00239169 | ||||||||
| Allele (153) | |||||||||
| Legacy_information | [C.elegansII] pk75 : excision derivative of pk27tci, 1.8 kb deletion; recessive lethal, L1/L2 arrest. Cloned: encodes 375 aa predicted protein, 66% identity with rat Gsalpha. gsa-1:lacZ expressed in many cells from late embryo onward. [Zwaal et al. 1993; NL] | ||||||||
| Strain | WBStrain00023478 | ||||||||
| WBStrain00023481 | |||||||||
| WBStrain00028905 | |||||||||
| WBStrain00051113 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (25) | |||||||||
| Ortholog (38) | |||||||||
| Paralog (21) | |||||||||
| Structured_description | Concise_description | The gsa-1 gene encodes a Gs alpha subunit of heterotrimeric G proteins which affects L1 larval stage viability, movement, and egg laying; it is genetically upstream of sgs-1 with respect to neuronal degeneration, as defined by gain-of-function analysis, and is expressed in excitable cells. | Paper_evidence | WBPaper00002824 | |||||
| Curator_confirmed | WBPerson1823 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Involved in several processes, including negative regulation of protein kinase C signaling; pharyngeal pumping; and positive regulation of oocyte maturation. Predicted to be part of heterotrimeric G-protein complex. Expressed in several structures, including excretory cell; intestine; neurons; non-striated muscle; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including ACTH-independent macronodular adrenal hyperplasia 1; Alzheimer's disease; dystonia 25; and pseudohypoparathyroidism (multiple). Is an ortholog of human GNAL (G protein subunit alpha L). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (13) | ||||||||
| Molecular_info | Corresponding_CDS | R06A10.2a | |||||||
| R06A10.2b | |||||||||
| Corresponding_CDS_history | R06A10.2:wp234 | ||||||||
| Corresponding_transcript | R06A10.2a.1 | ||||||||
| R06A10.2b.1 | |||||||||
| Other_sequence (79) | |||||||||
| Associated_feature (24) | |||||||||
| Experimental_info | RNAi_result (44) | ||||||||
| Expr_pattern | Expr686 | ||||||||
| Expr1489 | |||||||||
| Expr3593 | |||||||||
| Expr1013408 | |||||||||
| Expr1031038 | |||||||||
| Expr1155044 | |||||||||
| Expr2012282 | |||||||||
| Expr2030518 | |||||||||
| Drives_construct | WBCnstr00006670 | ||||||||
| WBCnstr00010301 | |||||||||
| WBCnstr00012490 | |||||||||
| WBCnstr00019885 | |||||||||
| Construct_product (8) | |||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (148) | |||||||||
| Interaction (84) | |||||||||
| WBProcess | WBbiopr:00000120 | ||||||||
| Map_info | Map | I | Position | -16.9676 | Error | 0.036154 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | R06A10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 3901 | |||||||
| 5345 | |||||||||
| Reference (72) | |||||||||
| Picture | WBPicture0000013094 | ||||||||
| Remark | A deletion derivative has been selected: pk75. It is a larval lethal. The insertion site of pk27 is: TAgatgtacaaaaaatgcgga (sequence Ohshima lab). | ||||||||
| Tc1 insertion polymorphism available. krb 04/03/02 | |||||||||
| Method | Gene |
