WormBase Tree Display for Gene: WBGene00000467

WBGene00000467 SMap: S_parent: Sequence: F52B5
  Identity (6)
  Gene_info: Biotype: SO:0001217
    Gene_class: cep
    Allele (54)
    Strain: WBStrain00022753
      WBStrain00034662
      WBStrain00034663
      WBStrain00034811
      WBStrain00035557
      WBStrain00040683
      WBStrain00004786
    RNASeq_FPKM (74)
    GO_annotation: 00068654
      00068655
      00068656
      00068657
      00068658
      00068659
      00068660
      00068661
      00068662
      00068663
      00068664
      00068665
      00068666
      00068667
      00068668
      00068669
      00068670
      00068671
      00068672
      00068673
      00068674
      00068675
      00068676
      00068677
      00068678
      00068679
      00068680
      00068681
      00068682
      00068683
      00068684
      00068685
      00068686
      00068687
      00068688
      00068689
      00068690
      00068691
      00106049
      00106052
      00106055
      00107444
      00107445
      00107446
      00107447
    Ortholog (17)
    Structured_description: Concise_description: cep-1 encodes an ortholog of the human tumor suppressor p53 (OMIM:191170, mutated in Li-Fraumeni syndrome) that promotes DNA damage-induced apoptosis and is required for normal meiotic segregation in the germ line, and affects sensitivity to hypoxia-induced lethality and longevity in response to starvation; CEP-1 is expressed ubiquitously in embryos and in the nucleoli of a subset of pharyngeal cells. Paper_evidence: WBPaper00004589
            WBPaper00004919
            WBPaper00004952
            WBPaper00012759
            WBPaper00012806
            WBPaper00013586
            WBPaper00013634
          Curator_confirmed: WBPerson48
            WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables several functions, including DNA-binding transcription factor activity; protein homodimerization activity; and zinc ion binding activity. Involved in several processes, including determination of adult lifespan; intracellular signal transduction; and positive regulation of transcription by RNA polymerase II. Located in germ cell nucleus; nucleolus; and nucleoplasm. Expressed in Z2; Z3; germ line; pharyngeal cell; and pharynx. Used to study cancer. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:162 Homo sapiens Paper_evidence: WBPaper00004952
          Curator_confirmed: WBPerson324
          Date_last_updated: 03 Feb 2020 00:00:00
  Models_disease_in_annotation: WBDOannot00000735
  Molecular_info: Corresponding_CDS: F52B5.5a
      F52B5.5b
    Corresponding_CDS_history: F52B5.5:wp68
    Corresponding_transcript: F52B5.5a.1
      F52B5.5b.1
      F52B5.5b.2
      F52B5.5b.3
      F52B5.5b.4
    Other_sequence: Tcir_isotig12051
      CBC03970_1
    Associated_feature: WBsf656624
      WBsf976837
      WBsf218143
    Gene_product_binds: WBsf034249
      WBsf034250
    Transcription_factor: WBTranscriptionFactor000114
  Experimental_info (11)
  Map_info: Map: I Position: 2.73569 Error: 0.00602
    Positive: Positive_clone: F52B5 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4212
        4897
    Pseudo_map_position
  Reference (251)
  Picture: WBPicture0000013091
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
    [wm99ab616], [wm2001p535] and [jwm2000ab65] used cep-1 as an unapproved name for CGC plx-2 (K04B12.1). The CGC cep-1 (F52B5.5) is a p53 homolog.
  Method: Gene