WormBase Tree Display for Gene: WBGene00000212
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WBGene00000212 | Evidence | Paper_evidence | WBPaper00003086 | ||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | ZK455 | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | asm | ||||||
Allele (50) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation | 00078658 | ||||||
00078659 | |||||||
00078660 | |||||||
00078661 | |||||||
00078662 | |||||||
00078663 | |||||||
00078664 | |||||||
00078665 | |||||||
00078666 | |||||||
00078667 | |||||||
00078668 | |||||||
00078669 | |||||||
00078670 | |||||||
00078671 | |||||||
00078672 | |||||||
00078673 | |||||||
00078674 | |||||||
00078675 | |||||||
00078676 | |||||||
00078677 | |||||||
00078678 | |||||||
00078679 | |||||||
00078680 | |||||||
00078681 | |||||||
00107029 | |||||||
00107030 | |||||||
00107031 | |||||||
00107032 | |||||||
Ortholog (40) | |||||||
Paralog | WBGene00000211 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | |||||||
WBGene00000213 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00014106 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
Structured_description | Concise_description | asm-2 encodes a protein similar to human acid sphingomyelinase (ASM) or sphingomyelin phosphodiesterase 1; the ASM-2 protein has a putative secretory signal peptide at the N-terminus, saposin-like and proline-rich domains and putative N-linked glycosylation sites; asm-2 shows phosphodiesterase activity when expressed in COS-7 cells; like mammalian ASM, asm-2 is probably both intracellular and secreted; northern blot analysis indicates that asm-2 is expressed during post-embryonic development as compared to asm-1 which is expressed at higher levels in the embryo; human ASM is implicated in Niemann-Pick disease type B (OMIM:607608). | Paper_evidence | WBPaper00003086 | |||
Curator_confirmed | WBPerson324 | ||||||
WBPerson1823 | |||||||
WBPerson567 | |||||||
Date_last_updated | 09 Aug 2006 00:00:00 | ||||||
Automated_description | Enables sphingomyelin phosphodiesterase activity. Involved in ceramide biosynthetic process and sphingomyelin catabolic process. Located in extracellular region. Human ortholog(s) of this gene implicated in Niemann-Pick disease type A and Niemann-Pick disease type B. Is an ortholog of human SMPD1 (sphingomyelin phosphodiesterase 1). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:14504 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11120) | ||
DOID:0070112 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11120) | ||||
DOID:0070111 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11120) | ||||
Molecular_info | Corresponding_CDS | ZK455.4 | |||||
Corresponding_CDS_history | ZK455.4:wp83 | ||||||
Corresponding_transcript | ZK455.4.1 | ||||||
Other_sequence (32) | |||||||
Associated_feature | WBsf654409 | ||||||
WBsf237956 | |||||||
Experimental_info | RNAi_result | WBRNAi00038298 | Inferred_automatically | RNAi_primary | |||
WBRNAi00059434 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00000331 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr1013294 | ||||||
Expr1162861 | |||||||
Expr2009455 | |||||||
Expr2027692 | |||||||
Drives_construct | WBCnstr00037660 | ||||||
Construct_product | WBCnstr00037660 | ||||||
Antibody | WBAntibody00001822 | ||||||
Microarray_results (18) | |||||||
Expression_cluster (207) | |||||||
Interaction | WBInteraction000133965 | ||||||
WBInteraction000177307 | |||||||
WBInteraction000290792 | |||||||
Map_info | Map | X | Position | 2.95988 | Error | 0.006229 | |
Positive | Positive_clone | ZK455 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Pseudo_map_position | |||||||
Reference (13) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |