WormBase Tree Display for Gene: WBGene00011064

WBGene00011064 SMap: S_parent: Sequence: R06C7
  Identity: Version: 2
    Name: CGC_name: adsl-1 Person_evidence: WBPerson10610
      Sequence_name: R06C7.5
      Molecular_name: R06C7.5a
        R06C7.5a.1
        CE06248
        R06C7.5b
        CE32476
        R06C7.5b.1
      Other_name: CELE_R06C7.5 Accession_evidence: NDB BX284601
      Public_name: adsl-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:52 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 11 Jul 2014 14:45:03 WBPerson2970 Name_change: CGC_name: adsl-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: adsl
    Allele (17)
    RNASeq_FPKM (74)
    GO_annotation: 00072773
      00072774
      00072775
      00072776
      00072777
      00072778
      00072779
      00072780
      00072781
      00072782
      00072783
      00072784
      00072785
      00072786
      00118357
    Contained_in_operon: CEOP1380
    Ortholog (39)
    Paralog: WBGene00001503 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: The R06C7.5 gene encodes an ortholog of the human gene ADSL, which when mutated leads to adenylosuccinate lyase deficiency (OMIM:103050). Paper_evidence: WBPaper00004637
          Curator_confirmed: WBPerson1823
            WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity and N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity. Predicted to be involved in 'de novo' AMP biosynthetic process. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in adenylosuccinase lyase deficiency; breast cancer; and prostate cancer. Is an ortholog of human ADSL (adenylosuccinate lyase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0050762 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:291)
      DOID:10283 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:291)
      DOID:1612 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:291)
  Molecular_info: Corresponding_CDS: R06C7.5a
      R06C7.5b
    Corresponding_CDS_history: R06C7.5:wp90
    Corresponding_transcript: R06C7.5a.1
      R06C7.5b.1
    Other_sequence (67)
    Associated_feature: WBsf219713
  Experimental_info: RNAi_result (18)
    Expr_pattern: Expr1012902
      Expr1034859
      Expr1155077
      Expr2009242
      Expr2027479
    Drives_construct: WBCnstr00030961
    Construct_product: WBCnstr00030961
    Microarray_results (27)
    Expression_cluster (133)
    Interaction: WBInteraction000037914
      WBInteraction000038875
      WBInteraction000111238
      WBInteraction000118916
      WBInteraction000125517
      WBInteraction000142276
      WBInteraction000150249
      WBInteraction000155525
      WBInteraction000155812
      WBInteraction000156039
      WBInteraction000156102
      WBInteraction000157301
      WBInteraction000180067
      WBInteraction000184201
      WBInteraction000201316
      WBInteraction000212559
      WBInteraction000225760
      WBInteraction000228232
      WBInteraction000228897
      WBInteraction000234273
      WBInteraction000239891
      WBInteraction000242742
      WBInteraction000270535
      WBInteraction000276742
      WBInteraction000278908
      WBInteraction000281026
      WBInteraction000289273
      WBInteraction000289526
      WBInteraction000292095
      WBInteraction000294860
      WBInteraction000295045
      WBInteraction000295046
      WBInteraction000295047
      WBInteraction000295048
      WBInteraction000295049
      WBInteraction000295050
      WBInteraction000295051
      WBInteraction000295052
      WBInteraction000296512
      WBInteraction000311696
      WBInteraction000319305
      WBInteraction000321679
      WBInteraction000332956
      WBInteraction000347924
      WBInteraction000373262
      WBInteraction000378315
      WBInteraction000378403
      WBInteraction000380351
      WBInteraction000397382
      WBInteraction000400109
      WBInteraction000405640
      WBInteraction000413380
      WBInteraction000415437
      WBInteraction000418419
      WBInteraction000419996
      WBInteraction000424381
      WBInteraction000426857
      WBInteraction000428483
      WBInteraction000432141
      WBInteraction000432972
      WBInteraction000434699
      WBInteraction000442569
      WBInteraction000445302
      WBInteraction000449358
      WBInteraction000449642
      WBInteraction000449747
      WBInteraction000451161
      WBInteraction000455010
      WBInteraction000459907
      WBInteraction000461525
      WBInteraction000466152
      WBInteraction000467024
      WBInteraction000467751
      WBInteraction000467875
      WBInteraction000468013
      WBInteraction000468568
      WBInteraction000468973
      WBInteraction000469254
      WBInteraction000470569
      WBInteraction000471259
      WBInteraction000471281
      WBInteraction000473238
      WBInteraction000475090
      WBInteraction000475369
      WBInteraction000523533
      WBInteraction000548570
      WBInteraction000551631
      WBInteraction000574265
      WBInteraction000577928
  Map_info: Map: I Position: 1.85739
    Positive: Positive_clone: R06C7 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (17)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene