WormBase Tree Display for Gene: WBGene00019820

WBGene00019820 SMap: S_parent: Sequence: R02D3
  Identity: Version: 2
    Name: CGC_name: cogc-8 Paper_evidence: WBPaper00026979
          Person_evidence: WBPerson449
      Sequence_name: R02D3.2
      Molecular_name: R02D3.2
        R02D3.2.1
        CE18096
      Other_name: CELE_R02D3.2 Accession_evidence: NDB BX284604
      Public_name: cogc-8
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:02 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 16 Jan 2006 17:12:59 WBPerson2970 Name_change: CGC_name: cogc-8
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cogc
    Allele (41)
    RNASeq_FPKM (74)
    GO_annotation: 00032578
      00032579
      00032580
      00032581
      00032582
      00032583
      00032584
      00032585
      00124585
    Ortholog (52)
    Structured_description: Concise_description: cogc-8 encodes an ortholog of mammalian COG-8, a subunit of lobe B ofthe conserved oligomeric Golgi complex (COGC); COGC-8 is weakly requiredfor normal gonadal distal tip cell migration, a process that alsorequires seven other orthologs of COGC subunits; like other lobe Bsubunits in both C. elegans and S. cerevisiae, COGC-8 is only partiallyrequired for normal function, while lobe A subunits are stronglyrequired in either worms or yeast. Paper_evidence: WBPaper00026979
            WBPaper00028363
            WBPaper00028599
            WBPaper00028603
          Curator_confirmed: WBPerson567
          Date_last_updated: 25 Oct 2006 00:00:00
      Automated_description: Involved in gonad morphogenesis and regulation of cell migration. Predicted to be located in Golgi membrane. Predicted to be part of Golgi transport complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIh. Is an ortholog of human COG8 (component of oligomeric golgi complex 8). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0070260 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:18623)
  Molecular_info: Corresponding_CDS: R02D3.2
    Corresponding_transcript: R02D3.2.1
    Other_sequence (13)
    Associated_feature: WBsf645745
      WBsf659867
      WBsf995108
      WBsf227817
      WBsf227818
      WBsf227819
  Experimental_info: RNAi_result: WBRNAi00064306 Inferred_automatically: RNAi_primary
      WBRNAi00017313 Inferred_automatically: RNAi_primary
      WBRNAi00099110 Inferred_automatically: RNAi_primary
      WBRNAi00034527 Inferred_automatically: RNAi_primary
      WBRNAi00051123 Inferred_automatically: RNAi_primary
    Expr_pattern (5)
    Drives_construct: WBCnstr00025571
    Construct_product: WBCnstr00025571
    Microarray_results (21)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00032031:DConiospora_upregulated_cDNA_24h
      WBPaper00032031:DConiospora_upregulated_OligoArray_24h
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00044736:flat_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00051039:germline_enriched
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051265:F1_morc-1(tm6048)_downregulated
      WBPaper00051265:F4_morc-1(tm6048)_upregulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053302:alovudine_24h_regulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
      WBPaper00053321:PGCs_enriched_NuGen
      WBPaper00053388:dauer_regulated_Cluster3
      WBPaper00053606:N2_vs_elt-2(ca15)_upregulated
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00055648:germline_expressed
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00058691:cfp-1(tm6369)_upregulated
      WBPaper00059224:tph-1(mg280)_downregulated
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061274:microgravity_upregulated
      WBPaper00061340:GLR
      WBPaper00061340:Neuroblast_AVG_RIR
      WBPaper00061479:HDA-1_interacting_protein
      WBPaper00061508:P.mirabilis_36h_upregulated
      WBPaper00061527:swsn-2.2_209-ets-6
      WBPaper00061753:csr-1(tor159)_downregulated_25C
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062590:Aging_downregulated_hypodermis
      WBPaper00064505:tamoxifen_upregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4489_group_8
      WBPaper00025032:cluster_53
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00032165:differentially_expressed_with_age_medoid_2
      WBPaper00036286:Pattern_F
      WBPaper00037901:GLD-1_mRNA_targets
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2down
      WBPaper00040963:TA300_down
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00042274:tbx-2(bx59)_downregulated
      WBPaper00047070:N2_starvation_downregulated
      [cgc5376]:let-60(G12V)-regulated_genes
      [cgc5767]:cluster_8
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_ET
      [cgc5767]:expression_class_ET_max(66_min)
      [cgc5767]:expression_class_E_pi(23_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc5767]:expression_class_MET
    Interaction (20)
  Map_info: Map: IV Position: -26.7831 Error: 0.004516
    Positive: Positive_clone: R02D3 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00032281
    WBPaper00038491
    WBPaper00055090
    WBPaper00061547
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene