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WormBase Tree Display for Gene: WBGene00011559

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Name Class

WBGene00011559SMapS_parentSequenceCHROMOSOME_III
Identity (6)
Gene_info (12)
Disease_infoExperimental_modelDOID:0050833Homo sapiensPaper_evidenceWBPaper00035924
WBPaper00044506
Accession_evidenceOMIM258900
Curator_confirmedWBPerson324
Date_last_updated24 Apr 2017 00:00:00
Potential_modelDOID:653Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12563)
DOID:0050833Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12563)
Disease_relevanceHuman Uridine monophosphate synthetase (UMPS) catalyses the last step of pyrimidine nucleotide synthesis which involves the conversion of orotate to uridine monophosphate (UMP); mutations in UMPS lead to Orotic aciduria; Orotic aciduria results in megaloblastic anemia and is associated with physical and mental retardation; in C. elegans, the loss of the bifunctional UMP synthase protein, umps-1, which carries catalytic activities for OPRTase (orotate phosphoribosyltransferase) and ODCase (orotate monophosphate decarboxylase) leads to both hypersensitivity to radiation and a decline in both metabolic rate and lifespan.Homo sapiensPaper_evidenceWBPaper00035924
Accession_evidenceOMIM258900
613891
Curator_confirmedWBPerson324
Date_last_updated24 Apr 2017 00:00:00
Models_disease_assertedWBDOannot00000005
WBDOannot00000411
Molecular_infoCorresponding_CDST07C4.1
Corresponding_transcriptT07C4.1.1
Other_sequence (23)
Associated_featureWBsf993989
WBsf993990
WBsf993991
WBsf1015775
WBsf227444
WBsf227445
WBsf227446
Experimental_infoRNAi_result (56)
Expr_patternExpr8781
Expr12838
Expr1016073
Expr1035094
Expr1156331
Expr2017831
Expr2035967
Drives_constructWBCnstr00007424
WBCnstr00013520
WBCnstr00030561
Construct_productWBCnstr00030561
Microarray_results (21)
Expression_clusterWBPaper00031040:TGF-beta_adult_downregulated
WBPaper00032031:DConiospora_upregulated_OligoArray_24h
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:coelomocytes_L2-larva_expressed
WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
WBPaper00037950:germline-precursors_blastula-embryo_expressed
WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
WBPaper00037950:hypodermis_L1-larva_expressed
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00037950:intestine_larva_enriched
WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
WBPaper00038168:lin-15B(n744)_downregulated
WBPaper00044501:gld-1_let-7_regulated
WBPaper00044578:4-day_reduced-humidity_downregulated_proteomics
WBPaper00044736:oscillating_dev_expression
WBPaper00044746:aging_downregulated_Day5
WBPaper00044746:aging_downregulated_HeatShock
WBPaper00045420:fertilization_downregulated_transcript
WBPaper00045521:Oogenic
WBPaper00045774:clk-1_downregulated
WBPaper00046012:tdp-1(ok803)_downregulated
WBPaper00048657:plep-1(ttTi53821)_regulated
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049545:cco-1(RNAi)_downregulated
WBPaper00049545:jmjd-3.1(+)_downregulated
WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
WBPaper00049942:HeatShock_upregulated_hsf-1(+)
WBPaper00050370:dpy-21(e428)_L3_downregulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050726:OsmoticStress_regulated_NoFood
WBPaper00050801:DAF-12_dauer_regulome
WBPaper00050801:DAF-16_dauer_regulome
WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00051039:germline_enriched
WBPaper00051245:body-wall-muscle_cytoplasm_expressed
WBPaper00051245:body-wall-muscle_nucleus_expressed
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:epidermis_nucleus_expressed
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00051245:intestine_nucleus_expressed
WBPaper00051404:alg-2(ok304)_upregulated
WBPaper00052884:emb-4(hc60)_downregulated
WBPaper00053184:sma-2(rax5)_downregulated
WBPaper00053184:sma-4(rax3)_downregulated
WBPaper00053289:DREAM-target
WBPaper00053302:alovudine_24h_regulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053302:zidovudine_24h_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
WBPaper00053388:dauer_regulated_Cluster6
WBPaper00053402:cco-1(RNAi)_downregulated
WBPaper00053599:female_vs_male_upregulated
WBPaper00053810:nuo-6(qm200)_downregulated
WBPaper00055013:hmg-3(bar24)_downregulated
WBPaper00055565:AVK_enriched
WBPaper00055648:germline_expressed
WBPaper00055971:nhl-2(ok818)_25C_downregulated
WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
WBPaper00056139:soil-microbiota_downregulated
WBPaper00056139:soil-microbiota_upregulated
WBPaper00056275:P.aeruginosa_downregulated
WBPaper00056275:P.aeruginosa_downregulated_pmk-1(km25)_dependent
WBPaper00056284:ints-5(RNAi)_downregulated
WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected
WBPaper00056443:sek-1(km4)_downregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
WBPaper00056471:S.aureus-4h_downregulated_N2
WBPaper00056826:SGP_biased
WBPaper00057041:spc-1(cas971)_upregulated
WBPaper00057041:unc-70(cas983)_upregulated
WBPaper00057154:HeatShock_downregulated_miRNA-target
WBPaper00057154:HeatShock_upregulated_mRNA
WBPaper00057288:Cold_downregulated_transcript
WBPaper00057288:iff-1(RNAi)_downregulated_transcript
WBPaper00058691:cfp-1(tm6369)_downregulated
WBPaper00058691:set-2(bn129)_downregulated
WBPaper00058691:sin-3(tm1276)_downregulated
WBPaper00058958:100mGy-irradiation-72h_upregulated
WBPaper00059328:mrps-5(RNAi)_downregulated_protein
WBPaper00059356:BAZ-2_SET-6_interacting
WBPaper00059605:MUT-16_interacting
WBPaper00059739:hira-1(gk835598)_downregulated_L1
WBPaper00059763:neuron_expressed
WBPaper00060661:sensory-neuron_depleted
WBPaper00060683:hlh-11(ko1)_upregulated
WBPaper00060811:L1_vs_adult_downregulated_neural
WBPaper00060871:M.humicola-extract_1h_regulated
WBPaper00061203:let-418(n3536)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061527:pbs-3_18439-rpn-5
WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
WBPaper00062056:lin-37(n758)_downregulated
WBPaper00062159:hda-2(ok1479)_downregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062520:qui-1(db104)_downregulated
WBPaper00062554:MAGU-2_interacting
WBPaper00062669:extracellular-vesicle_protein
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064107:lin-35(n745)_downregulated
WBPaper00064163:ZNFX-1_interacting_young-adult
WBPaper00064315:mes-4(bn73)_downregulated_PGCs
WBPaper00064494:postdauer_downregulated_AWA
WBPaper00064716:paraquat_upregulated
WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00065096:Day10_vs_Day1_downregulated
WBPaper00065373:Cisplatin_downregulated_WT
WBPaper00065373:sek-1(km4)_downregulated_Ref
WBPaper00065746:eat-2(ad1113)_downregulated
WBPaper00065841:76_0
WBPaper00065945:epidermis-rpoa-2(-)_downregulated_protein
WBPaper00065984:pals-17(syb3980)_downregulated
WBPaper00065993:glp-1(e2141)_downregulated
WBPaper00066085:sin-3(syb2172)_downregulated
WBPaper00066085:sin-3(tm1276)_downregulated
WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
cgc4489_group_3
WBPaper00024393:strongly_regulated_dauer_genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00031003:24hr_muscle_enriched
WBPaper00031003:total_muscle_enriched
WBPaper00031532:Larva_Pan_Neuronal_Depleted
WBPaper00032948:FedUp
WBPaper00034739:N2lessDR1350
WBPaper00035227:heat_shock_regulated
WBPaper00035905:FBF-1_Associated
WBPaper00036123:Atrazine_regulated
WBPaper00036286:Pattern_H
WBPaper00036375:depleted_in_PVD_OLL
WBPaper00038231:Cry5B_1.5-fold_downregulated
WBPaper00038231:Cry5B_2-fold_downregulated
WBPaper00041606:CE_B.thuringiensis-DB27_regulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_EtBr-exposed_51h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
WBPaper00042128:gei-8(ok1671)_downregulated
WBPaper00045263:0.1mM-paraquat_upregulated
WBPaper00045960:L4-lethargus_upregulated
WBPaper00047070:N2_starvation_downregulated
WBPaper00047070:xpa-1_UV_downregulated
WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
WBPaper00048989:N2_rapamycin_downregulated
WBPaper00053236:Starvation_regulated_N2
[cgc5767]:expression_class_E
[cgc5767]:expression_class_ET
[cgc5767]:expression_class_ET_max(122_min)
[cgc5767]:expression_class_E_pi(23_min)
[cgc5767]:expression_class_M
[cgc5767]:expression_class_MD
[cgc5767]:expression_class_MDE
[cgc5767]:expression_class_MDET
[cgc5767]:expression_class_MD_pd(23_min)
[cgc5767]:expression_class_ME
[cgc5767]:expression_class_MET
[cgc6390]:mixed_oogenesis-somatic
Interaction (115)
Map_infoMapIIIPosition2.47257Error0.002259
PositivePositive_cloneT07C4Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (16)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene