| WBGene00009372 | SMap | S_parent | Sequence | F34D10 |
|---|
| Identity | Version | 3 |
| | Name | CGC_name | evl-18 | Person_evidence | WBPerson220 |
| | | Sequence_name | F34D10.2 |
| | | Molecular_name | F34D10.2 |
| | | | F34D10.2.1 |
| | | | CE41399 |
| | | Other_name | cdc-45 | Person_evidence | WBPerson171 |
| | | | CELE_F34D10.2 | Accession_evidence | NDB | BX284603 |
| | | Public_name | evl-18 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 26 May 2004 16:54:50 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 |
| | | | 2 | 16 Jul 2007 10:16:17 | WBPerson1983 | Event | Split_into | WBGene00045484 |
| | | | 3 | 30 Aug 2012 13:10:47 | WBPerson2970 | Event | Acquires_merge | WBGene00001356 |
| | | | | | | Name_change | CGC_name | evl-18 |
| | | | | | | | Other_name | cdc-45 |
| | | Acquires_merge | WBGene00001356 |
| | | Split_into | WBGene00045484 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | evl |
| | Allele (68) |
| | Legacy_information | [C.elegansII] ar117 : everted vulva, sterile; no L4 vulval invagination; abnormal uterus; distal germline abnormal, no sperm or oocytes. NA1. [Seydoux et al., 1993] |
| | Strain | WBStrain00008015 |
| | RNASeq_FPKM (74) |
| | GO_annotation (14) |
| | Ortholog (36) |
| | Structured_description | Automated_description | Predicted to enable DNA replication origin binding activity; chromatin binding activity; and single-stranded DNA binding activity. Predicted to be involved in DNA replication initiation; double-strand break repair via break-induced replication; and mitotic DNA replication preinitiation complex assembly. Located in nucleus. Used to study chromosome 22q11.2 deletion syndrome, distal. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 7. Is an ortholog of human CDC45 (cell division cycle 45). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:0060413 | Homo sapiens | Paper_evidence | WBPaper00047004 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 20 Sep 2018 00:00:00 |
| | Potential_model | DOID:0080518 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1739) |
| | Disease_relevance | 22q11.2 deletion syndrome (22q11.2DS) is the most common human deletion syndrome caused by deletion of a small piece of chromosome 22, characterized by neurodevelopmental defects, schizophrenia, congenital cardiac and craniofacial abnormalites (includes DiGeorge Syndrome and velocardiofacial syndrome); the 22q11.2 deletion overlaps several protein-coding genes including CDC45; C. elegans CDC45/evl-18 is involved in DNA replication initiation as RNAi depletion of evl-18 affects DNA replication and delays S phase; evl-18 knock-down phenotypes include reduced brood size, early embryo sister chromatid segregration defects, and sperm development and sterility defects; evl-18 provides a potential model system to study genes involved in 22q11.2DS. | Homo sapiens | Paper_evidence | WBPaper00047004 |
| | | | | | WBPaper00040279 |
| | | | | | WBPaper00047062 |
| | | | | Accession_evidence | OMIM | 611867 |
| | | | | | | 603465 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 16 Sep 2015 00:00:00 |
| Models_disease_in_annotation | WBDOannot00000368 |
| Molecular_info | Corresponding_CDS | F34D10.2 |
| | Corresponding_CDS_history | F34D10.2:wp179 |
| | Corresponding_transcript | F34D10.2.1 |
| | Other_sequence (13) |
| | Associated_feature | WBsf650927 |
| | | WBsf666681 |
| | | WBsf666682 |
| | | WBsf991883 |
| | | WBsf991884 |
| | | WBsf226385 |
| | | WBsf226386 |
| | | WBsf226387 |
| Experimental_info | RNAi_result (16) |
| | Expr_pattern | Expr12321 |
| | | Expr1012133 |
| | | Expr1034106 |
| | | Expr1150133 |
| | | Expr2011388 |
| | | Expr2029624 |
| | Drives_construct | WBCnstr00032243 |
| | Construct_product | WBCnstr00032243 |
| | Antibody | WBAntibody00002758 |
| | Microarray_results (13) |
| | Expression_cluster | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00044316:CH3HgCl_7.5uM_upregulated |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044760:germline_specific |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045774:clk-1_downregulated |
| | | WBPaper00046509:htz-1(ok3099)_upregulated |
| | | WBPaper00046509:lin-35(n745)_upregulated |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049626:UNC-75_target |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi) |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00049954:BPS_downregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_25C |
| | | WBPaper00050488:mir-34(OverExpression)_vs_N2_regulated_adult_20C |
| | | WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C |
| | | WBPaper00050522:mafr-1(tm6082)_downregulated |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051265:F4_morc-1(tm6048)_upregulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053289:DREAM-target |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII |
| | | WBPaper00053388:dauer_regulated_Cluster2 |
| | | WBPaper00054493:hpl-2(tm1489)_downregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin_upregulated |
| | | WBPaper00055482:pmt-2(RNAi)_downregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056034:pals-22(jy3)_downregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056139:soil-microbiota_downregulated |
| | | WBPaper00056167:Cry5B_upregulated |
| | | WBPaper00056284:ints-5(RNAi)_downregulated |
| | | WBPaper00056290:hsp-6(mg585)_downregulated |
| | | WBPaper00056443:sek-1(km4)_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056619:CEPsh_enriched |
| | | WBPaper00057154:HeatShock_downregulated_mRNA |
| | | WBPaper00057154:HeatShock_upregulated_miRNA-target |
| | | WBPaper00058598:sin-3(tm1276)_upregulated |
| | | WBPaper00058969:RIS_depleted |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059664:srbc-48(ac23)_downregulated |
| | | WBPaper00060014:set-2(tm1630)_upregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060445:ikb-1(nr2027)_upregulated_L4 |
| | | WBPaper00060445:nfki-1(cer1)_upregulated_L4 |
| | | WBPaper00060459:bcat-1(RNAi)_downregulated |
| | | WBPaper00060661:sensory-neuron_depleted |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060909:atfs-1(cmh15)_upregulated |
| | | WBPaper00061007:S.aquatilis_downregulated |
| | | WBPaper00061106:endu-2(tm4977)_downregulated |
| | | WBPaper00061203:sin-3(tm1276)_downregulated |
| | | WBPaper00061203:spr-1(ok2144)_downregulated |
| | | WBPaper00061340:Parents_of_PHsh_hyp8_hyp9 |
| | | WBPaper00061340:RIB |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065096:25C_vs_20C_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065373:Cisplatin_upregulated_WT |
| | | WBPaper00065373:sek-1(km4)_upregulated_cisplatin |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066110:Doxorubicin_downregulated_diploid |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | cgc4489_group_5 |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00045673:colistin_downregulated |
| | | WBPaper00056330:mrps-5(RNAi)_downregulated |
| | Interaction (179) |
| Map_info | Positive | Positive_clone | F34D10 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 3473 |
| | Interpolated_map_position | III | -4.30176 |
| Reference | WBPaper00001738 |
| | WBPaper00015476 |
| | WBPaper00038491 |
| | WBPaper00040279 |
| | WBPaper00044861 |
| | WBPaper00049197 |
| | WBPaper00055090 |
| | WBPaper00056327 |
| | WBPaper00065080 |
| | WBPaper00066002 |
| Method | Gene |
