WormBase Tree Display for Gene: WBGene00007862

WBGene00007862 SMap: S_parent: Sequence: C32C4
  Identity: Version: 2
    Name: CGC_name: kvs-2 Person_evidence: WBPerson260
            WBPerson145
      Sequence_name: C32C4.1
      Molecular_name (24)
      Other_name: CELE_C32C4.1 Accession_evidence: NDB BX284605
      Public_name: kvs-2
    DB_info: Database: AceView gene 5L125
        WormQTL gene WBGene00007862
        WormFlux gene WBGene00007862
        NDB locus_tag CELE_C32C4.1
        Panther gene CAEEL|WormBase=WBGene00007862|UniProtKB=J3K003
          family PTHR11537
        NCBI gene 183120
        RefSeq protein NM_001269310.2
            NM_001129399.3
            NM_073324.6
            NM_001269311.3
            NM_001269306.3
            NM_001269307.4
            NM_001269309.4
            NM_001269308.3
        TrEMBL UniProtAcc D9N132
            D5MCS0
            D9N133
            A7UQ08
            Q18351
            J3K003
            D9N131
            H9G2X0
        UniProt_GCRP UniProtAcc J3K003
        OMIM gene 600397
            607604
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:48 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 10 Dec 2018 16:06:02 WBPerson1983 Name_change: CGC_name: kvs-2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: kvs
    Allele (123)
    Strain: WBStrain00055331
    RNASeq_FPKM (74)
    GO_annotation (22)
    Ortholog (77)
    Paralog (13)
    Structured_description: Automated_description: Predicted to enable delayed rectifier potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of voltage-gated potassium channel complex. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 26; intracranial hypertension; and retinal cone dystrophy 3B. Is an ortholog of human KCNF1 (potassium voltage-gated channel modifier subfamily F member 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0080461 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6231)
      DOID:9428 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6300)
      DOID:1826 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6231)
      DOID:0081022 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:19698)
  Molecular_info (5)
  Experimental_info: RNAi_result: WBRNAi00023069 Inferred_automatically: RNAi_primary
      WBRNAi00023153 Inferred_automatically: RNAi_primary
      WBRNAi00029408 Inferred_automatically: RNAi_primary
      WBRNAi00029410 Inferred_automatically: RNAi_primary
      WBRNAi00023953 Inferred_automatically: RNAi_primary
      WBRNAi00011471 Inferred_automatically: RNAi_primary
      WBRNAi00041659 Inferred_automatically: RNAi_primary
      WBRNAi00023665 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1029046
      Expr1033408
      Expr1145681
      Expr2001301
      Expr2012985
      Expr2019524
      Expr2031217
    Drives_construct: WBCnstr00033429
    Construct_product: WBCnstr00033429
    Microarray_results (28)
    Expression_cluster: WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_larva_enriched
      WBPaper00037950:all-neurons_larva_SelectivelyEnriched
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:AVE-neuron_embryo_enriched
      WBPaper00037950:AVE-neuron_embryo_SelectivelyEnriched
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_larva_enriched
      WBPaper00037950:glr-1(+)-neurons_larva_SelectivelyEnriched
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00042561:smgl-1(RNAi)_upregulated
      WBPaper00044037:eat-2_regulated_nhr-62_dependent
      WBPaper00044037:eat-2_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044760:somatic_specific
      WBPaper00045521:Spermatogenic
      WBPaper00045861:wdr-5(ok1417)_upregulated
      WBPaper00046024:sleep_upregulated_oscillating
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049377:MWCNT_upregulated
      WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_100-cell-embryo
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00051558:aging_regulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053388:dauer_regulated_Cluster4
      WBPaper00054758:alg-1(gk204)_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056275:P.aeruginosa_upregulated
      WBPaper00056275:P.aeruginosa_upregulated_atf-7(qd22qd130)_dependent
      WBPaper00056275:P.aeruginosa_upregulated_pmk-1(km25)_dependent
      WBPaper00056290:mdt-15(mg584)_downregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056826:hmc_biased
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00058969:RIS_enriched
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059728:5ug_cholesterol_upregulated
      WBPaper00059728:20ug_cholesterol_upregulated
      WBPaper00059763:neuron_expressed
      WBPaper00059987:Wounding_upregulated
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00060886:spr-5(by101);met-2(n4256)_downregulated
      WBPaper00061007:HB101_upregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061007:X.citri_upregulated
      WBPaper00061340:ASE_parent
      WBPaper00061340:AVH_parent
      WBPaper00061340:BAG
      WBPaper00061340:CAN
      WBPaper00061340:Ciliated_amphid_neuron
      WBPaper00061340:Ciliated_non_amphid_neuron
      WBPaper00061340:Glia
      WBPaper00061340:hyp4_hyp5_hyp6
      WBPaper00061340:Neuroblast_ADF_AWB
      WBPaper00061340:Neuroblast_AFD_RMD
      WBPaper00061340:Neuroblast_ALA_RMED
      WBPaper00061340:Neuroblast_ASE_ASJ_AUA
      WBPaper00061340:Neuroblast_ASJ_AUA
      WBPaper00061340:Neuroblast_BAG_SMDVx
      WBPaper00061340:RIA_parent
      WBPaper00061340:SMB
      WBPaper00061340:Z1_Z4
      WBPaper00061405:S.aureus_downregulated_starvation
      WBPaper00061424:Diet_MYb120_upregulated
      WBPaper00061466:nath-10(icb102)_downregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:acy-2-F35C5.11
      WBPaper00061651:ADF_enriched
      WBPaper00061651:AIB_enriched
      WBPaper00061651:ASER_enriched
      WBPaper00061651:ASG_enriched
      WBPaper00061651:AWC_OFF_enriched
      WBPaper00061651:AWC_ON_enriched
      WBPaper00061651:BAG_enriched
      WBPaper00061651:M1_enriched
      WBPaper00061651:PQR_enriched
      WBPaper00061651:RIH_enriched
      WBPaper00061651:RMD_LR_enriched
      WBPaper00061651:SMD_enriched
      WBPaper00061651:VA12_enriched
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00061995:mter-4(syb3662syb3403)_downregulated
      WBPaper00062095:unc-4(e120)_upregulated_VA-neuron
      WBPaper00062103:neuron_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062497:xpf-1(tm2842)_upregulated
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064602:egl-9(sa307)_downregulated
      WBPaper00064721:fasn-1(g14)_downregulated_starved
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065158:AFD_enriched
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065749:Heat-Shock_downregulated_N2
      WBPaper00065841:22_0
      WBPaper00065841:29_0
      WBPaper00065841:32_0
      WBPaper00065841:35_2
      WBPaper00065841:35_3
      WBPaper00065841:39_2
      WBPaper00065841:39_3
      WBPaper00065841:50_0
      WBPaper00065841:87_0
      WBPaper00065841:95_0
      WBPaper00065841:96_0
      WBPaper00065841:97_0
      WBPaper00065841:101_0
      WBPaper00065841:105_0
      WBPaper00065841:111_0
      WBPaper00065841:115_0
      WBPaper00065841:120_0
      WBPaper00065841:121_0
      WBPaper00065841:126_0
      WBPaper00065841:128_0
      WBPaper00065841:142_0
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066038:mip-1(how5)_upregulated
      WBPaper00066110:Cisplatin_upregulated_diploid
      WBPaper00066110:Doxorubicin_upregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      cgc4489_group_12
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00030839:Embryo_Pan_Neuronal
      WBPaper00030839:Larval_Pan_Neuronal
      WBPaper00031532:Larva_Pan_Neuronal_Enriched
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00045960:L1-L4-lethargus_upregulated
      WBPaper00045960:L4-lethargus_upregulated
      WBPaper00047070:N2_starvation_upregulated
    SAGE_tag: SAGE:tgtgatcgtcgtgctcc Strand: Antisense
      SAGE:aattacttgattcaagt Strand: Sense
        Unambiguously_mapped
      SAGE:cattcttgtc Strand: Antisense
      SAGE:tttttttatt Strand: Antisense
      SAGE:tttttgatca Strand: Sense
        Unambiguously_mapped
      SAGE:tcaggagtcgaccgaat Strand: Sense
        Unambiguously_mapped
      SAGE:tttttgatcacaggaat Strand: Sense
        Unambiguously_mapped
      SAGE:tcaggagtcg Strand: Sense
        Unambiguously_mapped
    Interaction: WBInteraction000139629
      WBInteraction000288481
      WBInteraction000365543
      WBInteraction000469833
      WBInteraction000472695
  Map_info: Map: V Position: 2.63385
    Positive: Positive_clone: C32C4 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00055090
  Remark: The gene name kvs-2 was incorrectly assigned to WBGene00206383 in 2011 but was reassigned to this gene in the WS270 release of WormBase.
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene