| WBGene00006922 | SMap | S_parent | Sequence | F08G12 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | vhl-1 | Person_evidence | WBPerson322 |
| | | Sequence_name | F08G12.4 |
| | | Molecular_name | F08G12.4 |
| | | | F08G12.4.1 |
| | | | CE03169 |
| | | Other_name | CELE_F08G12.4 | Accession_evidence | NDB | BX284606 |
| | | Public_name | vhl-1 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | vhl |
| | Allele (18) |
| | Strain | WBStrain00032096 |
| | | WBStrain00004655 |
| | | WBStrain00004677 |
| | | WBStrain00004678 |
| | | WBStrain00040827 |
| | RNASeq_FPKM (74) |
| | GO_annotation | 00063954 |
| | | 00063955 |
| | | 00063956 |
| | | 00063957 |
| | | 00063958 |
| | | 00063959 |
| | Ortholog (28) |
| | Structured_description (2) |
| Disease_info | Experimental_model | DOID:4467 | Homo sapiens | Paper_evidence | WBPaper00061713 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 28 Jun 2022 00:00:00 |
| | | DOID:14175 | Homo sapiens | Paper_evidence | WBPaper00024375 |
| | | | | | WBPaper00036343 |
| | | | | Accession_evidence | OMIM | 193300 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson38202 |
| | | | | Date_last_updated | 02 Jul 2018 00:00:00 |
| | Potential_model | DOID:0060474 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12687) |
| | | DOID:0050771 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12687) |
| | | DOID:10763 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12687) |
| | | DOID:8432 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12687) |
| | | DOID:4450 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12687) |
| | | DOID:3587 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12687) |
| | | DOID:1793 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12687) |
| | | DOID:9970 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12687) |
| | | DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12687) |
| | | DOID:14175 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12687) |
| | Disease_relevance | The human ortholog VHL is mutated in von Hippel-Landau syndrome; VHL functions as a recessive tumor suppressor gene and is involved in oxygen-sensing, microtubule stability and cilia formation; studies in elegans indicate that: the ubiquitin ligase vhl-1, and its target, the hif-1 hypoxic response transcription factor, modulate life-span, vhl-1 and hif-1 mutants are longer-lived; hif-1 also protects against DNA-damage-induced germ cell apoptosis by antagonizing the function of CEP-1, the homolog of the tumour suppressor p53. | Homo sapiens | Paper_evidence | WBPaper00038373 |
| | | | | Accession_evidence | OMIM | 193300 |
| | | | | | | 608537 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 14 Feb 2012 00:00:00 |
| Models_disease_in_annotation | WBDOannot00000043 |
| Models_disease_asserted | WBDOannot00000597 |
| | WBDOannot00000598 |
| | WBDOannot00000600 |
| | WBDOannot00000601 |
| | WBDOannot00001276 |
| Molecular_info | Corresponding_CDS | F08G12.4 |
| | Corresponding_transcript | F08G12.4.1 |
| | Associated_feature | WBsf648535 |
| | | WBsf1006969 |
| | | WBsf1006970 |
| | | WBsf1023853 |
| | | WBsf236370 |
| Experimental_info | RNAi_result (26) |
| | Expr_pattern | Expr8170 |
| | | Expr15110 |
| | | Expr1019223 |
| | | Expr1032939 |
| | | Expr1148006 |
| | | Expr2017996 |
| | | Expr2036132 |
| | Drives_construct | WBCnstr00013155 |
| | | WBCnstr00034097 |
| | | WBCnstr00042008 |
| | Construct_product | WBCnstr00013155 |
| | | WBCnstr00034097 |
| | Regulate_expr_cluster | WBPaper00024375:Up_N2_vs_vhl-1 |
| | | WBPaper00024375:Up_vhl-1_vs_hif-1_vhl-1 |
| | Antibody | WBAntibody00000414 |
| | Microarray_results (19) |
| | Expression_cluster | WBPaper00032976:non_compensated_genes |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:hypodermis_larva_enriched |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:intestine_larva_enriched |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_larva_enriched |
| | | WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq |
| | | WBPaper00042561:smg-2(RNAi)_downregulated |
| | | WBPaper00044316:CH3HgCl_7.5uM_downregulated |
| | | WBPaper00044426:rotenone_24h_upregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045486:starvation_downregulated |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045974:NSM_enriched_totalRNA_tiling |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h |
| | | WBPaper00048926:miaserin_upregulated_adult-day5 |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049484:elt-2(RNAi)_downregulated_L4 |
| | | WBPaper00049942:hsf-1(RNAi)_downregulated |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:intestine_enriched |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053599:female_vs_male_upregulated |
| | | WBPaper00053599:mitosis_vs_meiosis_downregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00056161:hermaphrodite_enriched_siRNA |
| | | WBPaper00056471:S.aureus-4h_downregulated_N2 |
| | | WBPaper00056855:his-72(uge40)_downregulated |
| | | WBPaper00060014:set-2(zr2012)_downregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00061341:28C_48h_downregulated |
| | | WBPaper00061527:K10C9.3_8160-Y39G8B.1_58 |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00064315:mes-3(bn199)_upregulated_EGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00066038:mip-1(how5)_downregulated |
| | | WBPaper00025032:cluster_91 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00030985:Photorhabdus_luminescens_upregulated |
| | | WBPaper00030985:Serratia_marcesens_upregulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00041002:HF_3d_0.2mM_Up |
| | | WBPaper00041002:HF_3d_2.0mM_Up |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00045263:isp-1(qm150)_upregulated |
| | | WBPaper00045263:nuo-6(qm200)_upregulated |
| | | WBPaper00045263:ProLongevity-mtROS_upregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | Interaction (35) |
| | WBProcess | WBbiopr:00000096 |
| Map_info | Map | X | Position | 2.87713 | Error | 0.015196 |
| | Positive | Positive_clone | F08G12 | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4067 |
| | | | 4442 |
| | | | 5397 |
| Reference (65) |
| Remark | Sequence connection from [Epstein ACR, Hodgkin JA, Ratcliffe PJ] |
| Method | Gene |
