WormBase Tree Display for Gene: WBGene00003951

WBGene00003951 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: K05C4
  Identity: Version: 1
    Name: CGC_name: pbs-5 Person_evidence: WBPerson1551
      Sequence_name: K05C4.1
      Molecular_name: K05C4.1
        K05C4.1.1
        CE19969
      Other_name: CELE_K05C4.1 Accession_evidence: NDB BX284601
      Public_name: pbs-5
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:33 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: pbs
    Allele (34)
    Strain: WBStrain00037464
    RNASeq_FPKM (74)
    GO_annotation (16)
    Contained_in_operon: CEOP1752
    Ortholog (48)
    Paralog (13)
    Structured_description: Automated_description: Predicted to enable endopeptidase activity. Predicted to be involved in proteasomal protein catabolic process. Predicted to be located in nucleus. Predicted to be part of proteasome core complex, beta-subunit complex. Human ortholog(s) of this gene implicated in JMP syndrome. Is an ortholog of human PSMB5 (proteasome 20S subunit beta 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0050553 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:9545)
  Modifies_disease: DOID:10652
  Modifies_disease_in_annotation (6)
  Molecular_info: Corresponding_CDS: K05C4.1
    Corresponding_transcript: K05C4.1.1
    Other_sequence (148)
    Associated_feature: WBsf649773
      WBsf665152
      WBsf981143
      WBsf220643
      WBsf220644
      WBsf220645
      WBsf220646
  Experimental_info: RNAi_result (18)
    Expr_pattern: Expr1019142
      Expr1031877
      Expr1153665
      Expr2014769
      Expr2033003
    Construct_product: WBCnstr00040745
    Microarray_results (20)
    Expression_cluster: WBPaper00024245:gst-5-binding_ROS-stressed
      WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00031674:feh-1(gb561)(RNAi)_downregulated
      WBPaper00032528:L3_enriched
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038289:oocyte_protein
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00042552:daf-2(e1370)_downregulated_daf-16-dependent
      WBPaper00044128:daf-2(e1370)_upregulated
      WBPaper00044128:DietaryRestriction_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00045774:clk-1_downregulated
      WBPaper00045974:NSM_enriched_totalRNA_RNAseq
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049498:npr-1(ur89)_regulated_3
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
      WBPaper00050332:skn-1(RNAi)_downregulated
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050468:hlh-30-dependent_Cry5B_regulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050686:glp-1(e2141)_downregulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:nucleus_specific
      WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
      WBPaper00053321:PGCs_enriched_NuGen
      WBPaper00053388:dauer_regulated_Cluster3
      WBPaper00053606:N2_vs_elt-2(ca15)_upregulated
      WBPaper00053810:clk-1(qm30)_downregulated
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00053810:isp-1(qm150)_downregulated
      WBPaper00053810:nuo-6(qm200)_downregulated
      WBPaper00053814:25C_downregulated_OP50
      WBPaper00053814:25C_downregulated_PY79
      WBPaper00054189:aging_regulated_protein
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055626:pry-1(mu38)_upregulated
      WBPaper00055648:germline_expressed
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056073:NHR-86_interacting_promoter
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_downregulated_N2
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058598:sin-3(tm1276)_upregulated
      WBPaper00058958:100mGy-irradiation-72h_upregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059328:mrps-5(RNAi)_downregulated_protein
      WBPaper00060014:set-2(tm1630)_upregulated
      WBPaper00060084:cco-1(RNAi)_downregulated_N2
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00061203:let-418(n3536)_downregulated
      WBPaper00061203:sin-3(tm1276)_downregulated
      WBPaper00061203:spr-1(ok2144)_downregulated
      WBPaper00061340:Excretory_cell
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061527:pbs-3_18439-rpn-5
      WBPaper00061651:CAN_enriched
      WBPaper00062143:PQN-59_interacting
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064055:trl-1(cas1077)_downregulated_starved
      WBPaper00064071:NHR-49_interacting
      WBPaper00064315:mrg-1(qa6200)_downregulated_PGCs
      WBPaper00064716:paraquat_upregulated
      WBPaper00064750:10mg-nanoplastics_upregulated_protein
      WBPaper00064871:hypoxia_upregulated_F2
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065158:AFD_depleted
      WBPaper00065258:anchor-cell_enriched
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065993:glp-1(e2141)_downregulated
      cgc4489_group_3
      WBPaper00005124:estrogen_10-5M_regulated
      WBPaper00025032:cluster_3
      WBPaper00025099:MA_specific
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026952:class_A
      WBPaper00030985:Photorhabdus_luminescens_upregulated
      WBPaper00031003:24hr_muscle_enriched
      WBPaper00031003:total_muscle_enriched
      WBPaper00032165:differentially_expressed_with_age_medoid_6
      WBPaper00032948:FedUp
      WBPaper00036286:Pattern_E
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00045960:L1-L4-lethargus_downregulated
      WBPaper00045960:L4-lethargus_downregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      [cgc5767]:cluster_1
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_MD
      [cgc5767]:expression_class_MD_pd(53_min)
      [cgc5767]:expression_class_SM
      [cgc5767]:expression_class_SMD
    Interaction (177)
  Map_info: Map: I Position: 26.4655 Error: 0.058283
    Positive: Positive_clone: K05C4 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (13)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene