WBGene00002987 | SMap | S_parent | Sequence | ZC64 |
| Identity | Version | 2 |
| | Name | CGC_name | lim-4 | Person_evidence | WBPerson545 |
| | | Sequence_name | ZC64.4 |
| | | Molecular_name | ZC64.4a |
| | | | ZC64.4a.1 |
| | | | CE25675 |
| | | | ZC64.4b |
| | | | CE51976 |
| | | | ZC64.4c |
| | | | CE52031 |
| | | | ZC64.4b.1 |
| | | | ZC64.4c.1 |
| | | Other_name | nss-1 | Paper_evidence | WBPaper00026818 |
| | | | CELE_ZC64.4 | Accession_evidence | NDB | BX284606 |
| | | Public_name | lim-4 |
| | DB_info | Database | AceView | gene | XE490 |
| | | | WormQTL | gene | WBGene00002987 |
| | | | WormFlux | gene | WBGene00002987 |
| | | | NDB | locus_tag | CELE_ZC64.4 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00002987|UniProtKB=G5EEA1 |
| | | | | family | PTHR24208 |
| | | | NCBI | gene | 180672 |
| | | | RefSeq | protein | NM_076268.2 |
| | | | | | NM_001351878.2 |
| | | | | | NM_001351879.2 |
| | | | SwissProt | UniProtAcc | G5EEA1 |
| | | | UniProt_GCRP | UniProtAcc | G5EEA1 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | | | 2 | 19 Dec 2005 14:58:13 | WBPerson2970 | Event | Acquires_merge | WBGene00003820 |
| | | | | | | Name_change | Other_name | nss-1 |
| | | Acquires_merge | WBGene00003820 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | lim |
| | Allele (81) |
| | Strain | WBStrain00001913 |
| | | WBStrain00023455 |
| | | WBStrain00029156 |
| | | WBStrain00005258 |
| | | WBStrain00049271 |
| | In_cluster | conserved_RDE-1_cluster |
| | RNASeq_FPKM (74) |
| | GO_annotation (23) |
| | Ortholog (38) |
| | Paralog (10) |
| | Structured_description | Concise_description | lim-4 encodes a LIM homeodomain protein homologous to murine Lhx6 and L3/Lhx7, and to Drosophila ARROWHEAD; LIM-4 is required for differentiation of AWB chemosensory neurons, for several but not all aspects of RID motor neuron differentiation, expression of ser-2, repulsion from chemosensory repellants, SAA neurite outgrowth, and normal locomotion and head foraging; lim-4 is expressed in AWB, RID, RIV, RMDL, RMDR, RMEV, four SAA neurons, and four SIA neurons. | Paper_evidence (2) |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell differentiation; positive regulation of transcription by RNA polymerase II; and serotonin biosynthetic process. Located in nucleus. Expressed in several structures, including ABalpppppa; head muscle; head neurons; lumbar neurons; and somatic nervous system. Is an ortholog of human LHX6 (LIM homeobox 6) and LHX8 (LIM homeobox 8). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase |
| | | | | Date_last_updated | 24 Apr 2024 00:00:00 |
| Molecular_info | Corresponding_CDS | ZC64.4a |
| | | ZC64.4b |
| | | ZC64.4c |
| | Corresponding_transcript | ZC64.4a.1 |
| | | ZC64.4b.1 |
| | | ZC64.4c.1 |
| | Other_sequence (14) |
| | Associated_feature | WBsf653872 |
| | | WBsf670378 |
| | | WBsf670379 |
| | | WBsf978715 |
| | | WBsf1004755 |
| | | WBsf237227 |
| | | WBsf237228 |
| | Gene_product_binds | WBsf979152 |
| | | WBsf979153 |
| | | WBsf979156 |
| | Transcription_factor | WBTranscriptionFactor000525 |
| Experimental_info | RNAi_result | WBRNAi00093991 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00021755 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00059017 | Inferred_automatically | RNAi_primary |
| | Expr_pattern (16) |
| | Drives_construct (8) |
| | Construct_product | WBCnstr00000961 |
| | | WBCnstr00005147 |
| | | WBCnstr00036303 |
| | | WBCnstr00038818 |
| | Microarray_results (18) |
| | Expression_cluster | WBPaper00029359_1291 |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_larva_enriched |
| | | WBPaper00037950:all-neurons_larva_SelectivelyEnriched |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045390:ubc-9(RNAi)_downregulated |
| | | WBPaper00045417:128Q-huntingtin_downreglated |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00050163:chd-3(eh4)_upregulated_100-cell-embryo |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050496:RID_enriched |
| | | WBPaper00050496:unc-39(hp701)_regulated |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050726:starvation_regulated_LowSalt |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:stavudine_72h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII |
| | | WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq |
| | | WBPaper00053771:up_at_dpy-7(e88) |
| | | WBPaper00054493:hpl-2(tm1489)_upregulated |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055226:ADR-2_target_N2 |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_upregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056167:Cry5B_upregulated |
| | | WBPaper00056169:rrf-3(pk1426)_upregulated_embryo |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058711:skn-1(lax188)_upregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated |
| | | WBPaper00059421:daf-3(mgDf90)_downregulated |
| | | WBPaper00059537:ngn-1(ok2200)_downregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060526:plp-1(ok2155)_downregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061081:E.faecalis_upregulated_skpo-1(ok1640) |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:ADF_AWB |
| | | WBPaper00061340:AWB |
| | | WBPaper00061340:Neuroblast_ADF_AWB |
| | | WBPaper00061340:RID |
| | | WBPaper00061340:RID_parent |
| | | WBPaper00061340:RIH |
| | | WBPaper00061340:RIV |
| | | WBPaper00061340:RMD |
| | | WBPaper00061340:RMED |
| | | WBPaper00061340:SIA |
| | | WBPaper00061340:SIB |
| | | WBPaper00061340:SMB |
| | | WBPaper00061340:SMD |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061527:F58E6.13_17427-ifa-3 |
| | | WBPaper00061651:AWB_enriched |
| | | WBPaper00061651:RID_enriched |
| | | WBPaper00061651:SAA_enriched |
| | | WBPaper00061651:SIB_enriched |
| | | WBPaper00061651:SMB_enriched |
| | | WBPaper00061753:csr-1(tor159)_upregulated_25C |
| | | WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062095:unc-4(e120)_upregulated_VA-neuron |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062440:crh-1(n3315)_downregulated |
| | | WBPaper00062446:nhr-8(hd117)_upregulated |
| | | WBPaper00062585:hlh-26(ok1453)_downregulated_E.faecium |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064661:lpd-3(ok2138)_upregulated |
| | | WBPaper00064721:fasn-1(g14)_downregulated_starved |
| | | WBPaper00064933:bcf-1(ylf1)_upregulated_transcript |
| | | WBPaper00065029:cadmium_upregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065158:25C_vs_15C_upregulated_WholeAnimal |
| | | WBPaper00065560:E.coli-HB101_downregulated_F3 |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065749:endu-2(tm4977)_upregulated |
| | | WBPaper00065841:22_0 |
| | | WBPaper00065841:29_0 |
| | | WBPaper00065841:46_0 |
| | | WBPaper00065841:76_0 |
| | | WBPaper00065841:94_0 |
| | | WBPaper00065841:101_0 |
| | | WBPaper00065841:115_0 |
| | | WBPaper00065841:129_0 |
| | | WBPaper00065841:130_0 |
| | | WBPaper00066085:hda-3(ok1991)_downregulated |
| | | WBPaper00066232:ash-2(RNAi)_upregulated_WT |
| | | cgc4489_group_18 |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00030985:Serratia_marcesens_upregulated |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00038427:lin-54_embryo_changed |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00046548:dafachronic-acid_upregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | Interaction (81) |
| Map_info | Map | X | Position | -9.21387 | Error | 0.024615 |
| | Positive | Positive_clone | ZC64 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4205 |
| | | | 4476 |
| | Pseudo_map_position |
| Reference (64) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |