WormBase Tree Display for Gene: WBGene00000501

WBGene00000501 SMap: S_parent: Sequence: C48D1
  Identity: Version: 1
    Name: CGC_name: cho-1 Person_evidence: WBPerson508
      Sequence_name: C48D1.3
      Molecular_name: C48D1.3
        C48D1.3.1
        CE27109
      Other_name: CELE_C48D1.3 Accession_evidence: NDB BX284604
      Public_name: cho-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cho
    Allele (91)
    Strain: WBStrain00004034
      WBStrain00004035
      WBStrain00033386
      WBStrain00033389
      WBStrain00036129
      WBStrain00033405
      WBStrain00033393
      WBStrain00033404
      WBStrain00033403
      WBStrain00033406
    RNASeq_FPKM (74)
    GO_annotation (24)
    Ortholog (41)
    Paralog (2)
    Structured_description: Concise_description: cho-1 encodes a high-affinity choline transporter orthologous to members of the sodium-dependent glucose transporter family; CHO-1 is expressed in cholinergic neurons. Paper_evidence: WBPaper00003947
            WBPaper00019363
          Curator_confirmed: WBPerson324
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables choline transmembrane transporter activity. Involved in choline transport. Located in axon; neuronal cell body; and synaptic vesicle. Expressed in head mesodermal cell; intestine; nerve ring; and neurons. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 20; distal hereditary motor neuronopathy type 7A; and major depressive disorder. Is an ortholog of human SLC5A7 (solute carrier family 5 member 7). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0111201 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14025)
      DOID:1470 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14025)
      DOID:1596 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14025)
      DOID:0110661 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14025)
  Molecular_info: Corresponding_CDS: C48D1.3
    Corresponding_CDS_history: C48D1.3:wp47
    Corresponding_transcript: C48D1.3.1
    Other_sequence (24)
    Associated_feature: WBsf945409 Paper_evidence: WBPaper00044605
      WBsf998358
      WBsf998359
      WBsf998360
      WBsf998361
      WBsf1018504
      WBsf1018505
      WBsf231100
  Experimental_info: RNAi_result: WBRNAi00007265 Inferred_automatically: RNAi_primary
      WBRNAi00029943 Inferred_automatically: RNAi_primary
      WBRNAi00042733 Inferred_automatically: RNAi_primary
      WBRNAi00075846 Inferred_automatically: RNAi_primary
      WBRNAi00012101 Inferred_automatically: RNAi_primary
    Expr_pattern (14)
    Drives_construct (22)
    Construct_product (11)
    Microarray_results (18)
    Expression_cluster: WBPaper00032425:up_in_rde-4
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00035211:age-1_vs_N2_downregulated
      WBPaper00037950:A-class-motor-neurons_CoreEnriched
      WBPaper00037950:A-class-motor-neurons_embryo_enriched
      WBPaper00037950:A-class-motor-neurons_embryo_SelectivelyEnriched
      WBPaper00037950:A-class-motor-neurons_larva_enriched
      WBPaper00037950:A-class-motor-neurons_larva_SelectivelyEnriched
      WBPaper00037950:all-neurons_larva_enriched
      WBPaper00037950:all-neurons_larva_SelectivelyEnriched
      WBPaper00037950:AVE-neuron_embryo_enriched
      WBPaper00037950:AVE-neuron_embryo_SelectivelyEnriched
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_larva_enriched
      WBPaper00037950:glr-1(+)-neurons_larva_SelectivelyEnriched
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038061:aldicarb_upregulated
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00042561:smgl-1(RNAi)_upregulated
      WBPaper00044037:eat-2_upregulated
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:flat_dev_expression
      WBPaper00046509:htz-1(ok3099)_downregulated
      WBPaper00046805:csr-1(RNAi)_upregulated_Set1
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053388:dauer_regulated_Cluster4
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin-Psora_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055648:male-tail_expressed
      WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056284:ints-1(RNAi)_downregulated
      WBPaper00056284:ints-11(RNAi)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056617:adr-1_upregulated_embryo_transcript
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058948:npr-8(ok1439)_downregulated_OP50
      WBPaper00058948:PA14_downregulated
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059566:wdr-23(mac32)_upregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059728:5ug_cholesterol_upregulated
      WBPaper00059728:20ug_cholesterol_upregulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061340:AIY
      WBPaper00061340:AVL
      WBPaper00061340:Neuroblast_HSN_PHB
      WBPaper00061340:RMD
      WBPaper00061340:SMD
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:xbx-3-DH11.5_20397
      WBPaper00061651:AIA_enriched
      WBPaper00061651:AIN_enriched
      WBPaper00061651:AS_enriched
      WBPaper00061651:DA_enriched
      WBPaper00061651:DB_enriched
      WBPaper00061651:IL2_DV_enriched
      WBPaper00061651:M5_enriched
      WBPaper00061651:PDA_enriched
      WBPaper00061651:PVP_enriched
      WBPaper00061651:RIB_enriched
      WBPaper00061651:RIF_enriched
      WBPaper00061651:RIH_enriched
      WBPaper00061651:RIR_enriched
      WBPaper00061651:RIV_enriched
      WBPaper00061651:RMD_DV_enriched
      WBPaper00061651:RMD_LR_enriched
      WBPaper00061651:RMF_enriched
      WBPaper00061651:RMH_enriched
      WBPaper00061651:SAB_enriched
      WBPaper00061651:SIA_enriched
      WBPaper00061651:SIB_enriched
      WBPaper00061651:SMB_enriched
      WBPaper00061651:SMD_enriched
      WBPaper00061651:URA_enriched
      WBPaper00061651:VA_enriched
      WBPaper00061651:VB02_enriched
      WBPaper00061753:csr-1(tor159)_downregulated_20C
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00061995:mter-4(syb3662syb3403)_downregulated
      WBPaper00062103:neuron_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
      WBPaper00064494:postdauer_upregulated_AWA
      WBPaper00064789:Day12_vs_Day1_upregulated_neuron
      WBPaper00064933:bcf-1(ylf1)_upregulated_transcript
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065749:Heat-Shock_downregulated_N2
      WBPaper00065841:6_0
      WBPaper00065841:6_1
      WBPaper00065841:6_2
      WBPaper00065841:6_3
      WBPaper00065841:14_1
      WBPaper00065841:22_0
      WBPaper00065841:28_0
      WBPaper00065841:29_0
      WBPaper00065841:32_0
      WBPaper00065841:46_0
      WBPaper00065841:50_0
      WBPaper00065841:52_0
      WBPaper00065841:55_0
      WBPaper00065841:76_0
      WBPaper00065841:96_0
      WBPaper00065841:103_0
      WBPaper00065841:104_0
      WBPaper00065841:111_0
      WBPaper00065841:117_0
      WBPaper00065841:121_0
      WBPaper00065841:126_0
      WBPaper00065841:128_0
      WBPaper00065841:130_0
      WBPaper00065841:133_0
      WBPaper00065841:134_0
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      cgc4489_group_14
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00030839:Larval_Pan_Neuronal
      WBPaper00031532:Larva_Pan_Neuronal_Enriched
      WBPaper00036286:Pattern_I
      WBPaper00040876:mir-35_downregulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_3h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00048637:lin-35(n745)_starvation_downregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
    Interaction (22)
  Map_info: Map: IV Position: 8.47547 Error: 0.003353
    Positive: Positive_clone: C48D1 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4218
    Pseudo_map_position
  Reference (22)
  Remark: Sequence connection from [Okuda T, Katsura I]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene