WormBase Tree Display for Gene: WBGene00002070

WBGene00002070 Evidence: Person_evidence: WBPerson842
  SMap: S_parent: Sequence: K07A1
  Identity: Version: 1
    Name: CGC_name: ile-1 Person_evidence: WBPerson842
      Sequence_name: K07A1.8
      Molecular_name: K07A1.8
        K07A1.8.1
        CE11854
      Other_name: CELE_K07A1.8 Accession_evidence: NDB BX284601
      Public_name: ile-1
    DB_info: Database: AceView gene 1K186
        WormQTL gene WBGene00002070
        WormFlux gene WBGene00002070
        NDB locus_tag CELE_K07A1.8
        Panther gene CAEEL|WormBase=WBGene00002070|UniProtKB=G5EDE8
          family PTHR12223
        NCBI gene 172799
        RefSeq protein NM_060147.7
        TREEFAM TREEFAM_ID TF313311
        TrEMBL UniProtAcc G5EDE8
        UniProt_GCRP UniProtAcc G5EDE8
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:26 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ile
    Allele (33)
    Strain: WBStrain00055467
    RNASeq_FPKM (74)
    GO_annotation: 00013889
      00013890
      00013891
      00013892
      00013893
      00013894
      00013895
      00105739
      00109967
    Ortholog: WBGene00026516 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00161381 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00162423 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00077035 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00134596 Caenorhabditis japonica From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00193453 Caenorhabditis brenneri From_analysis: WormBase-Compara
      WBGene00225110 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g12299 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g6829 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g3643 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g7738 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g13477 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g25315 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP31.g575 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g8050 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g18630 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g10347 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g7686 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g622 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00869.g14650 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-ile-1 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g14681 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00194.g6746 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_11623 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_000547 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g05972 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g631 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_10067700 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrI_pilon.g1856 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00206630 Caenorhabditis japonica From_analysis: WormBase-Compara
      WBGene00216559 Caenorhabditis japonica From_analysis: WormBase-Compara
      WBGene00237052 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00258749 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00287808 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000001846 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Panther
      SGD:S000004070 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Panther
      FB:FBgn0035909 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-060201-4 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:6631 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:6632 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
            PhylomeDB
      MGI:1917611 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:2667537 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
            PhylomeDB
      RGD:71020 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1310538 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
            PhylomeDB
    Paralog: WBGene00002071 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: ile-1 is orthologous to the human gene human ERGIC-53, which when mutated leads to deficiency of coagulation factors V/VIII (OMIM:227300). Paper_evidence: WBPaper00004103
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable mannose binding activity. Involved in IRE1-mediated unfolded protein response. Predicted to be located in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in factor V deficiency and factor XIII deficiency. Is an ortholog of human LMAN1 (lectin, mannose binding 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:2211 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6631)
      DOID:2216 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6631)
  Molecular_info: Corresponding_CDS: K07A1.8
    Corresponding_transcript: K07A1.8.1
    Other_sequence (64)
    Associated_feature: WBsf649498
      WBsf664767
      WBsf976906
      WBsf976907
      WBsf976908
      WBsf976909
      WBsf984761
      WBsf220109
      WBsf220110
      WBsf220111
  Experimental_info: RNAi_result: WBRNAi00076548 Inferred_automatically: RNAi_primary
      WBRNAi00003946 Inferred_automatically: RNAi_primary
      WBRNAi00116834 Inferred_automatically: RNAi_primary
      WBRNAi00050093 Inferred_automatically: RNAi_primary
      WBRNAi00034034 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1018481
      Expr1031223
      Expr1153795
      Expr2012718
      Expr2030954
    Drives_construct: WBCnstr00036477
    Construct_product: WBCnstr00036477
    Microarray_results (23)
    Expression_cluster: WBPaper00005700:transmembrane_protein
      WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00032528:L3_enriched
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00035073:mitochondria_protein
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00038118:stress_upregulated_N2
      WBPaper00038213:E.coli(LF82)_72h_upregulated
      WBPaper00038289:oocyte_protein
      WBPaper00040965:lipid-droplet_associated_protein
      WBPaper00044736:flat_dev_expression
      WBPaper00045774:clk-1_downregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046887:WNT-target
      WBPaper00048762:FOG-3_associated
      WBPaper00048988:neuron_expressed
      WBPaper00049217:DAF-16_downregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00049732:blmp-1(tm548);daf-7(e1372ts)_vs_daf-7(e1372ts)_downregulated
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053289:DREAM-target
      WBPaper00053302:alovudine_24h_regulated
      WBPaper00053302:zidovudine_24h_regulated
      WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_embryo_SMARTseq
      WBPaper00053388:dauer_regulated_Cluster5
      WBPaper00053713:Pheromone-induced_postdauer_vs_control_upregulated
      WBPaper00053810:nuo-6(qm200)_downregulated
      WBPaper00054410:set-26(tm2467)_downregulated
      WBPaper00054792:FOG-3_interacting
      WBPaper00055354:Rapamycin_upregulated
      WBPaper00055565:AVK_enriched
      WBPaper00055626:pry-1(mu38)_upregulated
      WBPaper00055648:germline_expressed
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056293:rpl-5(0)-rpl-33(0)_downregulated
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00056826:hmc_biased
      WBPaper00057041:spc-1(cas971)_upregulated
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00057158:mdt-15(tm2182)_dependent_15C_upregulated
      WBPaper00058725:sftb-1(cer39)_downregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059605:MUT-16_interacting
      WBPaper00059763:neuron_expressed
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00061340:g1A
      WBPaper00061340:g1A_g1P
      WBPaper00061340:mc3
      WBPaper00061340:Pharyngeal_marginal_cell
      WBPaper00061340:pm6
      WBPaper00061340:pm7
      WBPaper00061340:Posterior_arcade_cell
      WBPaper00061377:MYRF-1_interacting
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061527:tars-1-AFFX-r2-3026-5_at
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064201:SNA-3_interacting
      WBPaper00064716:paraquat_upregulated
      WBPaper00064871:hypoxia_upregulated_F2
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065373:sek-1(km4)_downregulated_cisplatin
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066085:sin-3(syb2172)_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4386_cluster_4_5
      cgc4489_group_3
      WBPaper00025032:cluster_1
      WBPaper00025032:cluster_6
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00032948:FedUp
      WBPaper00034757:down_by_oxidative_stress
      WBPaper00035084:L1_enriched_AIN-2_IP
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036286:Pattern_G
      WBPaper00037611:RNP-8-associated
      WBPaper00037695:WC_5-day
      WBPaper00037901:GLD-1_mRNA_targets
      WBPaper00038172:tax-6null_down_regulated
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_24h
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00048624:hlh-25(ok1710)_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      [cgc5767]:cluster_1
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_MD
      [cgc5767]:expression_class_MD_pd(41_min)
      [cgc5767]:expression_class_MD_pd(53_min)
      [cgc5767]:expression_class_SM
      [cgc5767]:expression_class_SMD
    Interaction (75)
  Map_info: Map: I Position: 3.8072 Error: 0.000397
    Positive: Positive_clone: K07A1 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00055090
    WBPaper00064057
    WBPaper00064339
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene