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WormBase Tree Display for Gene: WBGene00003171

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Name Class

WBGene00003171SMapS_parentSequenceZK154
IdentityVersion1
NameCGC_namemec-7Person_evidenceWBPerson95
Sequence_nameZK154.3
Molecular_nameZK154.3
ZK154.3.1
CE15257
Other_nameCELE_ZK154.3Accession_evidenceNDBBX284606
Public_namemec-7
DB_infoDatabase (10)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:31WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_info (11)
Disease_infoExperimental_modelDOID:14452Homo sapiensPaper_evidenceWBPaper00002711
Curator_confirmedWBPerson324
Date_last_updated24 Aug 2018 00:00:00
Potential_modelDOID:0112242Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:20778)
DOID:0090136Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:20778)
DOID:0112240Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:20771)
DOID:0060798Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:20774)
DOID:0090041Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:20774)
Disease_relevanceC. elegans mec-4 and deg-1 genes encode proteins, called degenerins, that are similar to the subunits of the human amiloride-sensitive epithelial sodium-channels; death-inducing substitutions in the gain-of-function mutant deg-1, e1611 and u231, may hyperactivate the channels, resulting in increased or altered ion flow and/osmotic imbalance and consequent neuron death; similarities between the degenerin-induced deaths and the early pathology of of neurons in human dominant myotonias, excitotoxicity, and epilepsy suggest similar mechanisms; studies with the elegans mutations show that the abnormalities infolding of the plasma membrane whorls, cytoplasmic vacuoles, cell swelling, chromatin aggregates and nuclear invaginations; mitochondria and golgi are not dramatically affected until the final stages of cell death when organelles, and sometimes the cells lyse; pathology of degeneration is dependent on abnormal degenerin gene dosage.Homo sapiensPaper_evidenceWBPaper00002711
Curator_confirmedWBPerson324
Date_last_updated13 Nov 2014 00:00:00
Models_disease_assertedWBDOannot00000609
Molecular_infoCorresponding_CDSZK154.3
Corresponding_transcriptZK154.3.1
Other_sequence (45)
Associated_featureWBsf654161
WBsf654162
WBsf977521
WBsf977522
WBsf977523
WBsf977524
WBsf1005948
WBsf1023307
WBsf237608
Experimental_infoRNAi_result (18)
Expr_patternExpr266
Expr1504
Expr1524
Expr1577
Expr11808
Expr1015364
Expr1031504
Expr1162675
Expr2013501
Expr2031735
Drives_constructWBCnstr00000459
WBCnstr00000463
WBCnstr00000465
WBCnstr00000480
WBCnstr00000481
WBCnstr00000563
WBCnstr00000568
WBCnstr00000569
WBCnstr00000616
WBCnstr00000678
WBCnstr00000693
WBCnstr00000694
WBCnstr00000696
WBCnstr00000846
WBCnstr00001033
WBCnstr00001034
WBCnstr00001255
WBCnstr00001256
WBCnstr00001257
WBCnstr00001258
WBCnstr00001259
WBCnstr00001260
WBCnstr00001261
WBCnstr00001263
WBCnstr00001265
WBCnstr00001271
WBCnstr00001273
WBCnstr00001274
WBCnstr00004734
WBCnstr00004735
WBCnstr00004736
WBCnstr00004737
WBCnstr00004738
WBCnstr00004741
WBCnstr00004743
WBCnstr00004744
WBCnstr00004745
WBCnstr00004746
WBCnstr00004747
WBCnstr00004748
WBCnstr00004749
WBCnstr00004750
WBCnstr00004765
WBCnstr00004766
WBCnstr00004767
WBCnstr00004768
WBCnstr00004789
WBCnstr00004790
WBCnstr00004841
WBCnstr00004842
WBCnstr00005666
WBCnstr00006314
WBCnstr00006329
WBCnstr00006352
WBCnstr00006357
WBCnstr00006437
WBCnstr00006460
WBCnstr00006473
WBCnstr00006498
WBCnstr00006499
WBCnstr00006838
WBCnstr00006842
WBCnstr00006843
WBCnstr00006897
WBCnstr00006898
WBCnstr00006899
WBCnstr00006900
WBCnstr00006901
WBCnstr00006902
WBCnstr00006914
WBCnstr00006928
WBCnstr00007345
WBCnstr00007369
WBCnstr00007609
WBCnstr00007635
WBCnstr00007639
WBCnstr00007640
WBCnstr00007641
WBCnstr00008039
WBCnstr00008040
WBCnstr00008041
WBCnstr00008042
WBCnstr00008043
WBCnstr00008824
WBCnstr00008858
WBCnstr00009025
WBCnstr00011691
WBCnstr00014463
WBCnstr00014464
WBCnstr00014574
WBCnstr00014767
WBCnstr00014768
WBCnstr00014769
WBCnstr00014770
WBCnstr00014771
WBCnstr00014772
WBCnstr00014773
WBCnstr00014774
WBCnstr00014896
WBCnstr00015522
WBCnstr00015523
WBCnstr00015528
WBCnstr00015549
WBCnstr00015550
WBCnstr00015551
WBCnstr00017125
WBCnstr00017126
WBCnstr00017127
WBCnstr00017128
WBCnstr00017129
WBCnstr00017130
WBCnstr00018111
WBCnstr00018126
WBCnstr00018127
WBCnstr00018128
WBCnstr00018129
WBCnstr00018233
WBCnstr00018336
WBCnstr00018375
WBCnstr00018967
WBCnstr00018968
WBCnstr00019059
WBCnstr00019060
WBCnstr00019061
WBCnstr00019062
WBCnstr00019375
WBCnstr00019461
WBCnstr00019540
WBCnstr00019543
WBCnstr00019744
WBCnstr00019745
WBCnstr00019748
WBCnstr00020483
WBCnstr00020485
WBCnstr00020626
WBCnstr00020677
WBCnstr00020765
WBCnstr00020766
WBCnstr00020767
WBCnstr00020768
WBCnstr00021720
WBCnstr00022698
WBCnstr00036199
WBCnstr00039540
WBCnstr00040056
WBCnstr00041713
WBCnstr00041900
WBCnstr00041901
WBCnstr00041902
WBCnstr00042120
WBCnstr00042121
WBCnstr00042122
WBCnstr00042126
WBCnstr00042127
Construct_productWBCnstr00000678
WBCnstr00001034
WBCnstr00015918
WBCnstr00036199
AntibodyWBAntibody00000087
WBAntibody00001541
WBAntibody00001774
WBAntibody00001775
Microarray_results (18)
Expression_cluster (243)
Interaction (229)
WBProcessWBbiopr:00000002
Map_infoMapXPosition-1.27615Error0.00769
Well_ordered
PositiveInside_rearrraDf7
Positive_cloneNW#B4
ZK154Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_data2_point167
672
1828
Multi_point (15)
Pos_neg_data7293
7294
7295
529
3176
9433
Reference (243)
MethodGene