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WormBase Tree Display for Gene: WBGene00004267

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Name Class

WBGene00004267SMapS_parentSequenceC18A3
IdentityVersion1
NameCGC_namerab-3Person_evidenceWBPerson451
Sequence_nameC18A3.6
Molecular_nameC18A3.6a
C18A3.6a.1
CE23555
C18A3.6b
CE20518
C18A3.6b.1
Other_nameRAB3/A
rbl-3
rab3Accession_evidenceEMBLAB112928
CELE_C18A3.6Accession_evidenceNDBBX284602
Public_namerab-3
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:34WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classrab
Allele (101)
Legacy_information[C.elegansII] y250 : mild Unc, Che, Egl defects; Ric.OA1: y251 (similar; both y250 and y251 are missense alleles). Encodes homolog of mammalian rab3 (73% identity to human Rab3a). Dominant negative transgene leads to Ric, some Unc, or L1 lethality like cha-1(0). [NM]
StrainWBStrain00035239
WBStrain00029038
WBStrain00029039
WBStrain00029047
WBStrain00029069
WBStrain00029076
WBStrain00040624
WBStrain00005440
WBStrain00034793
WBStrain00051851
WBStrain00055047
RNASeq_FPKM (74)
GO_annotation (37)
Ortholog (50)
Paralog (32)
Structured_descriptionConcise_descriptionrab-3 encodes a rab3 homolog, a member of the Ras GTPase superfamily, and affects sensitivity to aldicarb and the distribution of synaptic vesicle populations and thereby affects synaptic transmission, track amplitude and speed of movement, chemotaxis to isoamyl alcohol, affects pharyngeal pump durations, and may only slightly affect male mating behavior; requires aex-3 for localization to synapse-rich regions in axons and it is expressed in most or all neurons.Paper_evidenceWBPaper00002776
WBPaper00002918
WBPaper00004331
WBPaper00005654
Curator_confirmedWBPerson48
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionPredicted to enable GTPase activity and myosin V binding activity. Involved in several processes, including positive regulation of anterior/posterior axon guidance; regulation of GABAergic synaptic transmission; and ventral cord development. Located in neuron projection and synaptic vesicle. Expressed in nervous system; neurons; and uv1. Used to study alcohol use disorder and epilepsy. Is an ortholog of human RAB3A (RAB3A, member RAS oncogene family).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:1574Homo sapiensPaper_evidenceWBPaper00031669
Curator_confirmedWBPerson324
Date_last_updated13 Jun 2019 00:00:00
DOID:1826Homo sapiensPaper_evidenceWBPaper00035198
Curator_confirmedWBPerson38202
Date_last_updated04 Jun 2018 00:00:00
Models_disease_assertedWBDOannot00000559
WBDOannot00000713
Molecular_infoCorresponding_CDSC18A3.6a
C18A3.6b
Corresponding_transcriptC18A3.6a.1
C18A3.6b.1
Other_sequence (26)
Associated_feature (13)
Experimental_infoRNAi_result (17)
Expr_pattern (15)
Drives_constructWBCnstr00000257
WBCnstr00000260
WBCnstr00000261
WBCnstr00000263
WBCnstr00000351
WBCnstr00000573
WBCnstr00000574
WBCnstr00000699
WBCnstr00001641
WBCnstr00001642
WBCnstr00005088
WBCnstr00005089
WBCnstr00005090
WBCnstr00005221
WBCnstr00005222
WBCnstr00005791
WBCnstr00006301
WBCnstr00006302
WBCnstr00006337
WBCnstr00006666
WBCnstr00006667
WBCnstr00006974
WBCnstr00007311
WBCnstr00007402
WBCnstr00007662
WBCnstr00007717
WBCnstr00007720
WBCnstr00007854
WBCnstr00008008
WBCnstr00008009
WBCnstr00008010
WBCnstr00008011
WBCnstr00008275
WBCnstr00008276
WBCnstr00008583
WBCnstr00008822
WBCnstr00009952
WBCnstr00014478
WBCnstr00014594
WBCnstr00014595
WBCnstr00014596
WBCnstr00014597
WBCnstr00014688
WBCnstr00014806
WBCnstr00014809
WBCnstr00014814
WBCnstr00015407
WBCnstr00015837
WBCnstr00016645
WBCnstr00016961
WBCnstr00017693
WBCnstr00018573
WBCnstr00018619
WBCnstr00019000
WBCnstr00019027
WBCnstr00019115
WBCnstr00019153
WBCnstr00019471
WBCnstr00019533
WBCnstr00020019
WBCnstr00020190
WBCnstr00020462
WBCnstr00020463
WBCnstr00021634
WBCnstr00021635
WBCnstr00021643
WBCnstr00021645
WBCnstr00021650
WBCnstr00021712
WBCnstr00021713
WBCnstr00021714
WBCnstr00021824
WBCnstr00022609
WBCnstr00022611
WBCnstr00022676
WBCnstr00022678
WBCnstr00022800
WBCnstr00022835
WBCnstr00022849
WBCnstr00022854
WBCnstr00023007
WBCnstr00023124
WBCnstr00035600
WBCnstr00038067
WBCnstr00038246
WBCnstr00038357
WBCnstr00038741
WBCnstr00038785
WBCnstr00039268
WBCnstr00039538
WBCnstr00039936
WBCnstr00040107
WBCnstr00040181
WBCnstr00040182
WBCnstr00041284
WBCnstr00041715
WBCnstr00041728
WBCnstr00041729
WBCnstr00041730
WBCnstr00041743
WBCnstr00041885
WBCnstr00042673
WBCnstr00042675
WBCnstr00042709
WBCnstr00042873
WBCnstr00042898
WBCnstr00042899
WBCnstr00042901
Construct_product (92)
AntibodyWBAntibody00000151
WBAntibody00000729
WBAntibody00001350
WBAntibody00001587
Microarray_results (28)
Expression_cluster (233)
Interaction (66)
Map_infoMapIIPosition-0.958332Error0.001327
Well_ordered
PositivePositive_cloneC02C12Author_evidenceNonet MI
C18A3Inferred_automaticallyFrom sequence, transcript, pseudogene data
F11G1Author_evidenceNonet MI
Mapping_dataMulti_point3342
3346
Reference (180)
MethodGene