WormBase Tree Display for Gene: WBGene00002881
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| WBGene00002881 | SMap | S_parent | Sequence | C05D11 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | let-756 | Person_evidence | WBPerson533 | |||||
| Sequence_name | C05D11.4 | ||||||||
| Molecular_name | C05D11.4 | ||||||||
| C05D11.4.1 | |||||||||
| CE24786 | |||||||||
| Other_name | CELE_C05D11.4 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | let-756 | ||||||||
| DB_info | Database | AceView | gene | 3H497 | |||||
| WormQTL | gene | WBGene00002881 | |||||||
| WormFlux | gene | WBGene00002881 | |||||||
| NDB | locus_tag | CELE_C05D11.4 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00002881|UniProtKB=Q11184 | |||||||
| family | PTHR11486 | ||||||||
| NCBI | gene | 175909 | |||||||
| RefSeq | protein | NM_066002.7 | |||||||
| SwissProt | UniProtAcc | Q11184 | |||||||
| UniProt_GCRP | UniProtAcc | Q11184 | |||||||
| OMIM | gene | 165190 | |||||||
| 300070 | |||||||||
| 300827 | |||||||||
| 600921 | |||||||||
| 601513 | |||||||||
| 601515 | |||||||||
| 602115 | |||||||||
| 605558 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:29 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | let | ||||||||
| Allele (35) | |||||||||
| Legacy_information | [Stewart HI, Vatcher GP, Kuervers LM] homozygotes arrest development at early larval stage | ||||||||
| Complementation_data | [Stewart HI, Vatcher GP, Kuervers LM] complements let-713 (s2470), let-716(s2457), let-721(s2447), let-728(2573), let-747(s2456), let-767(s2464), let-774(s2615), mel-32(s2518). | ||||||||
| Strain | WBStrain00003338 | ||||||||
| WBStrain00029348 | |||||||||
| WBStrain00029349 | |||||||||
| WBStrain00030728 | |||||||||
| WBStrain00030730 | |||||||||
| WBStrain00030732 | |||||||||
| WBStrain00000805 | |||||||||
| WBStrain00007480 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (50) | |||||||||
| Ortholog (99) | |||||||||
| Paralog | WBGene00001185 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | let-756 encodes an fibroblast growth factor (FGF)-like ligand that is required for progression through early larval development; LET-756 is expressed from late embryogenesis to adulthood, with a peak of expression in larvae; with EGL-17, LET-756 is redundantly required to activate EGL-15/FGFR, which in turn activates protein degradation in adult muscle cells; homozygotes for partial loss-of-function alleles are small, clear, and scrawny, but viable, while those for a null allele arrest in early larval development. | Paper_evidence | WBPaper00003796 | |||||
| WBPaper00006119 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; growth factor activity; and protein kinase binding activity. Involved in fibroblast growth factor receptor signaling pathway; nematode larval development; and regulation of cellular component organization. Located in cytoplasm; extracellular space; and nuclear lumen. Expressed in several structures, including CAN; OLL; cephalic sensillum; muscle cell; and pharyngeal cell. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; brain disease (multiple); carcinoma (multiple); and eye disease (multiple). Is an ortholog of human FGF3 (fibroblast growth factor 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (63) | ||||||||
| Molecular_info | Corresponding_CDS | C05D11.4 | |||||||
| Corresponding_transcript | C05D11.4.1 | ||||||||
| Other_sequence | HG11763 | ||||||||
| HBC26670_1 | |||||||||
| ES743171.1 | |||||||||
| HGC05346_1 | |||||||||
| JI170611.1 | |||||||||
| Associated_feature (15) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00068091 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00039736 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00030220 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00010198 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090613 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00005843 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00116212 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00116194 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00039737 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00010197 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (16) | |||||||||
| Drives_construct | WBCnstr00002169 | ||||||||
| WBCnstr00003809 | |||||||||
| WBCnstr00004243 | |||||||||
| WBCnstr00006605 | |||||||||
| WBCnstr00006606 | |||||||||
| WBCnstr00007859 | |||||||||
| WBCnstr00011210 | |||||||||
| WBCnstr00012221 | |||||||||
| WBCnstr00016114 | |||||||||
| WBCnstr00016115 | |||||||||
| WBCnstr00016116 | |||||||||
| WBCnstr00020506 | |||||||||
| WBCnstr00036316 | |||||||||
| Construct_product | WBCnstr00000107 | ||||||||
| WBCnstr00006605 | |||||||||
| WBCnstr00006606 | |||||||||
| WBCnstr00007860 | |||||||||
| WBCnstr00012221 | |||||||||
| WBCnstr00036316 | |||||||||
| Antibody | WBAntibody00001059 | ||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (128) | |||||||||
| Interaction (235) | |||||||||
| Anatomy_function | WBbtf0316 | ||||||||
| WBbtf0317 | |||||||||
| WBbtf1057 | |||||||||
| WBbtf1058 | |||||||||
| Map_info | Map | III | Position | -1.28614 | Error | 0.006892 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | sDf127 | |||||||
| sDf125 | |||||||||
| sDp3 | |||||||||
| Positive_clone | C05D11 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| pGV1 | |||||||||
| Negative | Outside_rearr | nDf16 | |||||||
| sDf135 | |||||||||
| sDp8 | |||||||||
| Mapping_data | 2_point | 7085 | |||||||
| Multi_point | 3592 | ||||||||
| 4991 | |||||||||
| 5627 | |||||||||
| 5643 | |||||||||
| Pos_neg_data | 9229 | ||||||||
| 9230 | |||||||||
| 9231 | |||||||||
| 9232 | |||||||||
| 9233 | |||||||||
| 10215 | |||||||||
| 10216 | |||||||||
| Reference (47) | |||||||||
| Remark | pGV1 is a subclone of C05D11 containing ORFs 4 and 5. | ||||||||
| Method | Gene |
