WormBase Tree Display for Gene: WBGene00003784
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WBGene00003784 | SMap | S_parent | Sequence | ZK1127 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | nos-2 | Person_evidence | WBPerson575 | |||||
Sequence_name | ZK1127.1 | ||||||||
Molecular_name | ZK1127.1 | ||||||||
ZK1127.1.1 | |||||||||
CE05121 | |||||||||
Other_name | CELE_ZK1127.1 | Accession_evidence | NDB | BX284602 | |||||
Public_name | nos-2 | ||||||||
DB_info | Database | AceView | gene | 2H357 | |||||
WormQTL | gene | WBGene00003784 | |||||||
WormFlux | gene | WBGene00003784 | |||||||
NDB | locus_tag | CELE_ZK1127.1 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00003784|UniProtKB=Q23406 | |||||||
family | PTHR12887 | ||||||||
NCBI | gene | 174158 | |||||||
RefSeq | protein | NM_063051.7 | |||||||
TREEFAM | TREEFAM_ID | TF318878 | |||||||
TrEMBL | UniProtAcc | Q23406 | |||||||
UniProt_GCRP | UniProtAcc | Q23406 | |||||||
OMIM | gene | 608226 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | nos | ||||||||
Allele (22) | |||||||||
Legacy_information | [Seydoux G] No mutants known. Encodes protein with similarity to Drosophila nanos. Predicted gene ZK1127.1 | ||||||||
Strain | WBStrain00022251 | ||||||||
WBStrain00003947 | |||||||||
WBStrain00022439 | |||||||||
WBStrain00022445 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (15) | |||||||||
Ortholog (19) | |||||||||
Paralog (2) | |||||||||
Structured_description | Concise_description | nos-2 encodes one of three genes in C. elegans that contains a putative zinc-binding domain similar to the one found in Drosophila nanos; nos-2 affects incorporation of primordial germ cells into the somatic gonad, is required redundantly with nos-1 to prevent primordial germ cells from dividing in starved animals and to maintain germ cell viability during larval development in hermaphrodites and in males, and also functions together with nos-1 and nos-3 in the hermaphrodite switch from spermatogenesis to oogenesis; nos-2 is expressed in the primordial germ cells around the time of gastrulation from a maternal RNA associated with P granules, and it is expressed coordinately with nos-1in a dynamic fashion until the embryonic 200-cell stage. | Paper_evidence | WBPaper00003692 | |||||
WBPaper00003762 | |||||||||
WBPaper00004672 | |||||||||
Curator_confirmed | WBPerson48 | ||||||||
Date_last_updated | 11 Mar 2005 00:00:00 | ||||||||
Automated_description | Predicted to enable mRNA binding activity and zinc ion binding activity. Involved in oogenesis and regulation of cell cycle. Located in cytoplasm. Expressed in P0; P4; Z2; and Z3. Human ortholog(s) of this gene implicated in spermatogenic failure 12. Is an ortholog of human NANOS1 (nanos C2HC-type zinc finger 1); NANOS2 (nanos C2HC-type zinc finger 2); and NANOS3 (nanos C2HC-type zinc finger 3). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:0070171 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:23044) | ||||
Molecular_info | Corresponding_CDS | ZK1127.1 | |||||||
Corresponding_transcript | ZK1127.1.1 | ||||||||
Other_sequence | CJC04685_1 | ||||||||
CJC06275_1 | |||||||||
CSC01626_1 | |||||||||
CBC00647_1 | |||||||||
FD515793.1 | |||||||||
CR01356 | |||||||||
CRC01394_1 | |||||||||
Associated_feature (14) | |||||||||
Experimental_info | RNAi_result (41) | ||||||||
Expr_pattern | Expr1159 | ||||||||
Expr1161 | |||||||||
Expr1031770 | |||||||||
Expr1162550 | |||||||||
Expr2014357 | |||||||||
Expr2032598 | |||||||||
Drives_construct | WBCnstr00035869 | ||||||||
Construct_product | WBCnstr00035869 | ||||||||
Antibody | WBAntibody00000247 | ||||||||
Microarray_results (29) | |||||||||
Expression_cluster (190) | |||||||||
Interaction (234) | |||||||||
Map_info | Map | II | Position | 0.381622 | Error | 0.021659 | |||
Positive | Positive_clone | ZK1127 | Author_evidence | Seydoux GC | |||||
Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
Mapping_data | Multi_point | 4542 | |||||||
Pseudo_map_position | |||||||||
Reference (64) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |