WormBase Tree Display for Gene: WBGene00003497
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WBGene00003497 | Evidence | CGC_data_submission | |||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | K07D8 | ||||||
Identity | Version | 1 | |||||||
Name | CGC_name | mup-4 | Person_evidence | WBPerson1052 | |||||
Sequence_name | K07D8.1 | ||||||||
Molecular_name | K07D8.1 | ||||||||
K07D8.1.1 | |||||||||
CE29511 | |||||||||
Other_name | CELE_K07D8.1 | Accession_evidence | NDB | BX284603 | |||||
Public_name | mup-4 | ||||||||
DB_info | Database (11) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:32 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | mup | ||||||||
Allele (135) | |||||||||
Legacy_information | [Gatewood B, Bucher EA] mg36 is lethal, abnormal muscle positioning. | ||||||||
[C.elegansII] mg36 : lethal, embryonic arrest at 3-fold, defective muscle attachment, abnormal hypodermis; muscle cells collapse from ventral side, retract from head and tail; some embryos arrested earlier. Mosaic analysis indicates focus in AB. OA>5: ar60, mg23, mg36, s2433 etc. [BC; EE; GR] | |||||||||
[Stewart HI, Chamberlin HM] Homozygous s2433 arrest at a mid larval stage. | |||||||||
Strain (8) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (14) | |||||||||
Ortholog (44) | |||||||||
Paralog (13) | |||||||||
Structured_description | Concise_description | The mup-4 gene encodes a novel transmembrane protein required for junctional attachments between hypodermis and muscle, and between the apical epithelial surface and the cuticular matrix. | Paper_evidence | WBPaper00002771 | |||||
WBPaper00004798 | |||||||||
Curator_confirmed | WBPerson567 | ||||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
Automated_description | Predicted to enable calcium ion binding activity. Predicted to be involved in cell adhesion. Located in hemidesmosome. Part of hemidesmosome associated protein complex. Expressed in body wall musculature; hypodermis; pharynx; touch receptor neurons; and vulval cell. Human ortholog(s) of this gene implicated in multiple epiphyseal dysplasia 5 and osteoarthritis. Is an ortholog of human MATN2 (matrilin 2) and MATN3 (matrilin 3). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:2256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6909) | ||||
DOID:0070299 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6909) | ||||||
DOID:8398 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6909) | ||||||
Molecular_info | Corresponding_CDS | K07D8.1 | |||||||
Corresponding_transcript | K07D8.1.1 | ||||||||
Other_sequence (20) | |||||||||
Associated_feature | WBsf651204 | ||||||||
WBsf667077 | |||||||||
WBsf667078 | |||||||||
WBsf717084 | |||||||||
WBsf717928 | |||||||||
WBsf993012 | |||||||||
WBsf993013 | |||||||||
WBsf993014 | |||||||||
WBsf993015 | |||||||||
WBsf1015239 | |||||||||
WBsf1015240 | |||||||||
WBsf1015241 | |||||||||
WBsf1015242 | |||||||||
WBsf226983 | |||||||||
WBsf226984 | |||||||||
WBsf226985 | |||||||||
WBsf226986 | |||||||||
WBsf226987 | |||||||||
Experimental_info | RNAi_result (41) | ||||||||
Expr_pattern | Expr1626 | ||||||||
Expr15945 | |||||||||
Expr1023788 | |||||||||
Expr1031600 | |||||||||
Expr1153857 | |||||||||
Expr2013826 | |||||||||
Expr2032066 | |||||||||
Drives_construct | WBCnstr00004800 | ||||||||
WBCnstr00007539 | |||||||||
WBCnstr00010356 | |||||||||
WBCnstr00036086 | |||||||||
Construct_product | WBCnstr00007539 | ||||||||
WBCnstr00010356 | |||||||||
WBCnstr00036086 | |||||||||
Antibody | WBAntibody00000390 | ||||||||
Microarray_results (20) | |||||||||
Expression_cluster (263) | |||||||||
Interaction (32) | |||||||||
WBProcess | WBbiopr:00000006 | ||||||||
Map_info | Map | III | Position | -0.729766 | Error | 0.000597 | |||
Well_ordered | |||||||||
Positive | Positive_clone | K07D8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Negative | Outside_rearr | nDf20 | |||||||
Mapping_data | Multi_point | 3191 | |||||||
3192 | |||||||||
4013 | |||||||||
4014 | |||||||||
4214 | |||||||||
Pos_neg_data | 8681 | ||||||||
8707 | |||||||||
8710 | |||||||||
8722 | |||||||||
8805 | |||||||||
8814 | |||||||||
9708 | |||||||||
Reference (36) | |||||||||
Remark | Moved from -0.739 [sdm/jah 5/99] | ||||||||
The mutation s2833 was previously assigned to let-794. | |||||||||
Sequence connection from [Gatewood BK, Bucher EA] | |||||||||
Method | Gene |