WormBase Tree Display for Gene: WBGene00004210
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| WBGene00004210 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | Y110A2AL | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | ptc-3 | Person_evidence | WBPerson349 | |||||
| Sequence_name | Y110A2AL.8 | ||||||||
| Molecular_name | Y110A2AL.8a | ||||||||
| Y110A2AL.8a.1 | |||||||||
| CE37163 | |||||||||
| Y110A2AL.8b | |||||||||
| CE37164 | |||||||||
| Y110A2AL.8c | |||||||||
| CE42182 | |||||||||
| Y110A2AL.8b.1 | |||||||||
| Y110A2AL.8c.1 | |||||||||
| Other_name | Y110A2AL.j | Curator_confirmed | WBPerson1983 | ||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CELE_Y110A2AL.8 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | ptc-3 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ptc | ||||||||
| Allele (195) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (14) | |||||||||
| Ortholog (41) | |||||||||
| Paralog (31) | |||||||||
| Structured_description | Concise_description | ptc-3 encodes an ortholog of Drosophila PATCHED (PTC) and human PTCH(OMIM:601309, mutated in basal cell nevus syndrome), which defines oneof seven paralogous families of sterol sensing domain (SSD) proteins;PTC-3 is strongly required for normal molting from L1 to L3 larvalstages; PTC-3 is also required for normal growth to full size and forviability. | Paper_evidence | WBPaper00004265 | |||||
| WBPaper00026841 | |||||||||
| WBPaper00027263 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 08 Nov 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable hedgehog family protein binding activity; hedgehog receptor activity; and smoothened binding activity. Involved in molting cycle. Located in apical plasma membrane and cytoplasmic vesicle. Expressed in several structures, including CEP; cloaca; egg-laying apparatus; excretory duct; and preanal ganglion. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); colorectal adenoma; and holoprosencephaly 7. Is an ortholog of human PTCH1 (patched 1) and PTCH2 (patched 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (18) | ||||||||
| Molecular_info | Corresponding_CDS | Y110A2AL.8a | |||||||
| Y110A2AL.8b | |||||||||
| Y110A2AL.8c | |||||||||
| Corresponding_CDS_history | Y110A2AL.8a:wp127 | ||||||||
| Y110A2AL.8b:wp127 | |||||||||
| Corresponding_transcript | Y110A2AL.8a.1 | ||||||||
| Y110A2AL.8b.1 | |||||||||
| Y110A2AL.8c.1 | |||||||||
| Other_sequence | CRC01499_1 | ||||||||
| JI466102.1 | |||||||||
| FC542662.1 | |||||||||
| RS10592 | |||||||||
| Oden_isotig18879 | |||||||||
| TSC10955_1 | |||||||||
| HBC18725_1 | |||||||||
| EX564995.1 | |||||||||
| BMC12862_1 | |||||||||
| Dviv_isotig06231 | |||||||||
| CBC13056_1 | |||||||||
| Dviv_isotig06232 | |||||||||
| CR01496 | |||||||||
| MAC02080_1 | |||||||||
| BM00762 | |||||||||
| MA01112 | |||||||||
| EX501518.1 | |||||||||
| Acan_isotig02692 | |||||||||
| JI479119.1 | |||||||||
| ES567197.1 | |||||||||
| CR02074 | |||||||||
| JI164462.1 | |||||||||
| DN153091.1 | |||||||||
| ACC30645_1 | |||||||||
| RS06795 | |||||||||
| RSC04460_1 | |||||||||
| FC548736.1 | |||||||||
| Dviv_contig12364 | |||||||||
| FC549925.1 | |||||||||
| MHC09340_1 | |||||||||
| TSC07345_1 | |||||||||
| ACC24546_1 | |||||||||
| Acan_isotig02691 | |||||||||
| CRC04917_1 | |||||||||
| Associated_feature | WBsf649949 | ||||||||
| WBsf665411 | |||||||||
| WBsf665412 | |||||||||
| WBsf987076 | |||||||||
| WBsf987077 | |||||||||
| WBsf987078 | |||||||||
| WBsf987079 | |||||||||
| WBsf1011782 | |||||||||
| WBsf1011783 | |||||||||
| WBsf1011784 | |||||||||
| WBsf1011785 | |||||||||
| WBsf222808 | |||||||||
| WBsf222809 | |||||||||
| Experimental_info | RNAi_result (14) | ||||||||
| Expr_pattern | Expr9231 | ||||||||
| Expr9232 | |||||||||
| Expr1017786 | |||||||||
| Expr1032067 | |||||||||
| Expr1158842 | |||||||||
| Expr2015145 | |||||||||
| Expr2033383 | |||||||||
| Drives_construct | WBCnstr00008494 | ||||||||
| WBCnstr00008496 | |||||||||
| WBCnstr00035634 | |||||||||
| Construct_product | WBCnstr00008494 | ||||||||
| WBCnstr00008495 | |||||||||
| WBCnstr00008496 | |||||||||
| WBCnstr00008497 | |||||||||
| WBCnstr00008498 | |||||||||
| WBCnstr00008502 | |||||||||
| WBCnstr00035634 | |||||||||
| Antibody | WBAntibody00002998 | ||||||||
| Microarray_results (31) | |||||||||
| Expression_cluster (200) | |||||||||
| Interaction (78) | |||||||||
| WBProcess | WBbiopr:00000123 | ||||||||
| Map_info | Map | II | Position | -9.82406 | Error | 0.084736 | |||
| Positive | Positive_clone | Y110A2AL | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00004265 | ||||||||
| WBPaper00011630 | |||||||||
| WBPaper00011803 | |||||||||
| WBPaper00022467 | |||||||||
| WBPaper00023346 | |||||||||
| WBPaper00024393 | |||||||||
| WBPaper00026841 | |||||||||
| WBPaper00027263 | |||||||||
| WBPaper00030463 | |||||||||
| WBPaper00031588 | |||||||||
| WBPaper00037993 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00051709 | |||||||||
| WBPaper00053154 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00057653 | |||||||||
| WBPaper00060487 | |||||||||
| WBPaper00061789 | |||||||||
| WBPaper00064105 | |||||||||
| WBPaper00064957 | |||||||||
| WBPaper00065833 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
