WormBase Tree Display for Gene: WBGene00000776

WBGene00000776 Evidence: Paper_evidence: WBPaper00004821
  SMap: S_parent: Sequence: T03E6
  Identity: Version: 1
    Name: CGC_name: cpl-1
      Sequence_name: T03E6.7
      Molecular_name: T03E6.7a
        T03E6.7a.1
        CE16333
        T03E6.7b
        CE47424
        T03E6.7b.1
      Other_name: CELE_T03E6.7 Accession_evidence: NDB BX284605
      Public_name: cpl-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cpl
    Allele: WBVar01778184
      WBVar01778185
      WBVar01778186
      WBVar01778187
      WBVar01778188
      WBVar01976509
      WBVar01976510
      WBVar01778189
      WBVar01778190
      WBVar01778191
      WBVar01493083
      WBVar01778192
      WBVar01778193
      WBVar01778194
      WBVar01778195
      WBVar01778196
      WBVar01778197
      WBVar02107729
      WBVar01778198
      WBVar00481666
      WBVar02107730
      WBVar01778199
      WBVar00481667
      WBVar02107731
      WBVar01778200
      WBVar00481668
      WBVar01778201
      WBVar00481669
      WBVar02107732
      WBVar00481670
      WBVar01778202
      WBVar02107733
      WBVar00481671
      WBVar01778203
      WBVar00481672
      WBVar01778204
      WBVar01778205
      WBVar01778206
      WBVar01593723
      WBVar01778207
      WBVar01778208
      WBVar01778209
      WBVar01778210
      WBVar01778211
      WBVar01778212
      WBVar00039645
      WBVar01778213
      WBVar01778214
      WBVar01778215
      WBVar00039650
      WBVar01778216
      WBVar01778217
      WBVar01778218
      WBVar02124497
      WBVar01897035
      WBVar01778219
      WBVar01897036
      WBVar00039655
      WBVar01778220
      WBVar01897037
      WBVar01778221
      WBVar00039660
      WBVar01778222
      WBVar01778223
      WBVar02114013
      WBVar01778224
      WBVar00039665
      WBVar01778225
      WBVar02032338
      WBVar00039670
      WBVar02032339
      WBVar02110706
      WBVar00039675
      WBVar02110707
      WBVar00246044
      WBVar02122859
      WBVar00246045
      WBVar00091657
      WBVar01081437
      WBVar01894444
      WBVar01081438
      WBVar01081439
      WBVar02122684
      WBVar01081440
      WBVar01081441
      WBVar01081442
      WBVar01081443
      WBVar01081444
      WBVar01081445
      WBVar01081446
      WBVar01081447
      WBVar01081448
      WBVar00272961
      WBVar02050100
      WBVar01081449
      WBVar00272962
      WBVar01081450
      WBVar01081451
      WBVar00272963
      WBVar01081452
      WBVar00272964
      WBVar01081453
      WBVar00272965
      WBVar01907410
      WBVar00272966
      WBVar01081454
      WBVar01081455
      WBVar02124908
      WBVar00272967
      WBVar01907411
      WBVar00272968
      WBVar01081456
      WBVar01907412
      WBVar01907413
      WBVar01081457
      WBVar01081458
      WBVar01907414
      WBVar01907415
      WBVar01081459
      WBVar01081460
      WBVar01907416
      WBVar01081461
      WBVar02070311
      WBVar02025114
      WBVar01081462
      WBVar01081463
      WBVar01081464
      WBVar01081465
      WBVar01081466
      WBVar01081467
      WBVar01081468
      WBVar01081469
      WBVar02117931
      WBVar02068847
      WBVar02068848
      WBVar01498710
      WBVar02121634
      WBVar02137880
      WBVar02123303
      WBVar01634293
      WBVar01634294
      WBVar01634295
      WBVar01634296
      WBVar01634297
      WBVar01634298
      WBVar01498548
      WBVar02121292
      WBVar02043842
      WBVar02124059
      WBVar02124428
      WBVar01499299
      WBVar02145389
      WBVar01778157
      WBVar01778158
      WBVar02145390
      WBVar01778159
      WBVar01778160
      WBVar01778161
      WBVar01778162
      WBVar01778163
      WBVar02124626
      WBVar01778164
      WBVar01778165
      WBVar02123708
      WBVar01778166
      WBVar01778167
      WBVar01778168
      WBVar01778169
      WBVar01778170
      WBVar01778171
      WBVar01488830
      WBVar01778172
      WBVar01778173
      WBVar02125669
      WBVar01778174
      WBVar02125670
      WBVar01778175
      WBVar01778176
      WBVar01778177
      WBVar01778178
      WBVar00594064
      WBVar00594067
      WBVar01778179
      WBVar01778180
      WBVar00594068
      WBVar01778181
      WBVar01778182
      WBVar01778183
    Strain: WBStrain00035678
    RNASeq_FPKM (74)
    GO_annotation (34)
    Ortholog (69)
    Paralog (28)
    Structured_description: Concise_description: cpl-1 encodes a member of the cathepsin L-like cysteine protease family required for embryonic viability and normal growth; expressed in eggshells and throughout early embryos, accumulates in intestinal cells during late embryogenesis, and expressed in the cuticle, gonad, and pharynx later in development. Paper_evidence: WBPaper00005099
            WBPaper00005654
            WBPaper00011657
            WBPaper00023209
          Curator_confirmed: WBPerson48
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable cysteine-type endopeptidase activity. Involved in several processes, including lipid droplet disassembly; positive regulation of vitellogenesis; and regulation of apoptosis involved in tissue homeostasis. Located in several cellular components, including lysosome; vesicle lumen; and yolk granule. Expressed in several structures, including cuticle; eggshell; hermaphrodite gonad; pharynx; and vulva. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy and type 2 diabetes mellitus. Is an ortholog of human CTSL (cathepsin L). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:11984 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2537)
      DOID:9352 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2537)
  Molecular_info: Corresponding_CDS: T03E6.7a
      T03E6.7b
    Corresponding_transcript: T03E6.7a.1
      T03E6.7b.1
    Other_sequence (287)
    Associated_feature (13)
  Experimental_info: RNAi_result (20)
    Expr_pattern (17)
    Drives_construct (5)
    Construct_product: WBCnstr00010434
      WBCnstr00015512
      WBCnstr00016652
      WBCnstr00018463
      WBCnstr00018464
      WBCnstr00019401
      WBCnstr00037285
    Regulate_expr_cluster: WBPaper00064728:cpl-1(W32AY35A)_upregulated
    Antibody: WBAntibody00000451
      WBAntibody00000800
      WBAntibody00000801
      WBAntibody00000802
      WBAntibody00000803
      WBAntibody00002885
      WBAntibody00002910
    Microarray_results (23)
    Expression_cluster (236)
    Interaction (107)
  Map_info: Map: V Position: 10.72
    Positive: Positive_clone: T03E6 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4236
    Pseudo_map_position
  Reference (37)
  Remark: Sequence connection from [Hashmi S, Britton C, Lustigman S], 02/06/13 krb.
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
    [200225 pad] Modified Map position as it was a reverse physical that could not be fixed by automated methods. (10.5333)
  Method: Gene