[C.elegansII] sy187 : negatively regulates vulval differentiation;20C no phenotype alone, 25C some excess vulval differentiation; more in sli-1(sy243) background. [PS]
ark-1 encodes a homolog of the nonreceptor tyrosine kinase ACK which inhibits signalling through the EGF receptor homolog LET-23, both in (RAS-dependent) vulval development and in (RAS-independent) ovulation.
Predicted to enable protein tyrosine kinase activity. Involved in embryo development; negative regulation of epidermal growth factor receptor signaling pathway; and negative regulation of vulval development.