F53F4.10 is orthologous to the human gene NADH-ubiquinone oxidoreductase flavoprotein 2 (NDUFV2; complex I of the respiratory chain); F53F4.10 protein is predicted to be mitochondrial.
Predicted to enable 2 iron, 2 sulfur cluster binding activity; NADH dehydrogenase (ubiquinone) activity; and metal ion binding activity. Predicted to contribute to NADH dehydrogenase activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Predicted to be located in mitochondrial inner membrane and respirasome. Predicted to be part of mitochondrial respiratory chain complex I. Used to study mitochondrial metabolism disease. Human ortholog(s) of this gene implicated in Parkinson's disease and nuclear type mitochondrial complex I deficiency 7. Is an ortholog of human NDUFV2 (NADH:ubiquinone oxidoreductase core subunit V2).
Inferred by orthology to human genes with DO annotation (HGNC:7717)
Disease_relevance
Mutations in the human gene NADH-ubiquinone oxidoreductase flavoprotein 2 (NDUFV2; complex I of the respiratory chain), orthologous to the elegans gene, F53F4.10, have been associated with Mitochondrial complex I deficiency.
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.