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WormBase Tree Display for Gene: WBGene00009992

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Name Class

WBGene00009992SMapS_parentSequenceF53F4
IdentityVersion2
NameCGC_namenduv-2Person_evidenceWBPerson555
Sequence_nameF53F4.10
Molecular_nameF53F4.10
F53F4.10.1
CE10972
Other_nameCELE_F53F4.10Accession_evidenceNDBBX284605
Public_namenduv-2
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change126 May 2004 16:54:50WBPerson1971EventImportedInitial conversion from CDS class of WS125
216 Jan 2023 18:37:21WBPerson51134Name_changeCGC_namenduv-2
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classnduv
AlleleWBVar01499886
WBVar02125272
WBVar00013235
WBVar01062456
WBVar01062457
WBVar01062458
WBVar01062459
WBVar01062460
WBVar00475278
WBVar01499621
WBVar01870675
WBVar01870676
WBVar01500212
WBVar01500213
WBVar01499299
WBVar01499316
RNASeq_FPKM (74)
GO_annotation (16)
Contained_in_operonCEOP5392
Ortholog (36)
Structured_descriptionConcise_descriptionF53F4.10 is orthologous to the human gene NADH-ubiquinone oxidoreductase flavoprotein 2 (NDUFV2; complex I of the respiratory chain); F53F4.10 protein is predicted to be mitochondrial.Paper_evidenceWBPaper00004424
Curator_confirmedWBPerson324
WBPerson1823
WBPerson567
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionPredicted to enable 2 iron, 2 sulfur cluster binding activity; NADH dehydrogenase (ubiquinone) activity; and metal ion binding activity. Predicted to contribute to NADH dehydrogenase activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Predicted to be located in mitochondrial inner membrane and respirasome. Predicted to be part of mitochondrial respiratory chain complex I. Used to study mitochondrial metabolism disease. Human ortholog(s) of this gene implicated in Parkinson's disease and nuclear type mitochondrial complex I deficiency 7. Is an ortholog of human NDUFV2 (NADH:ubiquinone oxidoreductase core subunit V2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:700Homo sapiensPaper_evidenceWBPaper00057247
WBPaper00064182
Curator_confirmedWBPerson324
Date_last_updated11 Oct 2022 00:00:00
Potential_modelDOID:14330Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:7717)
DOID:0112092Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:7717)
Disease_relevanceMutations in the human gene NADH-ubiquinone oxidoreductase flavoprotein 2 (NDUFV2; complex I of the respiratory chain), orthologous to the elegans gene, F53F4.10, have been associated with Mitochondrial complex I deficiency.Homo sapiensAccession_evidenceOMIM252010
600532
Curator_confirmedWBPerson324
Date_last_updated23 Jul 2013 00:00:00
Models_disease_in_annotationWBDOannot00000212
WBDOannot00001332
WBDOannot00001336
Molecular_infoCorresponding_CDSF53F4.10
Corresponding_transcriptF53F4.10.1
Other_sequence (100)
Associated_featureWBsf653329
WBsf234836
Experimental_infoRNAi_result (14)
Expr_patternExpr1020378
Expr1034355
Expr1151956
Expr2004071
Expr2022295
Drives_constructWBCnstr00031758
Construct_productWBCnstr00031758
Microarray_results (19)
Expression_cluster (104)
InteractionWBInteraction000029108
WBInteraction000105245
WBInteraction000105246
WBInteraction000105579
WBInteraction000105629
WBInteraction000107024
WBInteraction000109744
WBInteraction000122448
WBInteraction000147769
WBInteraction000150600
WBInteraction000152159
WBInteraction000153347
WBInteraction000153377
WBInteraction000153432
WBInteraction000153468
WBInteraction000153497
WBInteraction000153609
WBInteraction000153658
WBInteraction000154079
WBInteraction000154174
WBInteraction000155247
WBInteraction000155507
WBInteraction000155535
WBInteraction000155555
WBInteraction000155556
WBInteraction000155557
WBInteraction000155558
WBInteraction000155559
WBInteraction000155560
WBInteraction000155561
WBInteraction000155562
WBInteraction000155563
WBInteraction000155564
WBInteraction000155565
WBInteraction000155566
WBInteraction000155567
WBInteraction000155568
WBInteraction000155569
WBInteraction000155830
WBInteraction000155970
WBInteraction000156150
WBInteraction000157412
WBInteraction000157442
WBInteraction000157460
WBInteraction000157468
WBInteraction000157481
WBInteraction000157482
WBInteraction000157483
WBInteraction000157484
WBInteraction000157485
WBInteraction000157486
WBInteraction000157487
WBInteraction000157488
WBInteraction000157489
WBInteraction000157490
WBInteraction000157491
WBInteraction000157522
WBInteraction000157535
WBInteraction000157547
WBInteraction000163406
WBInteraction000175867
WBInteraction000176760
WBInteraction000178075
WBInteraction000181831
WBInteraction000186175
WBInteraction000190492
WBInteraction000190959
WBInteraction000191051
WBInteraction000196292
WBInteraction000203140
WBInteraction000213004
WBInteraction000213702
WBInteraction000221144
WBInteraction000225512
WBInteraction000225749
WBInteraction000232233
WBInteraction000233858
WBInteraction000234604
WBInteraction000236956
WBInteraction000249738
WBInteraction000260244
WBInteraction000265611
WBInteraction000266515
WBInteraction000292883
WBInteraction000294260
WBInteraction000296796
WBInteraction000302501
WBInteraction000303543
WBInteraction000309641
WBInteraction000316951
WBInteraction000317926
WBInteraction000329113
WBInteraction000331175
WBInteraction000332827
WBInteraction000339461
WBInteraction000339897
WBInteraction000355607
WBInteraction000369975
WBInteraction000372314
WBInteraction000373111
WBInteraction000375488
WBInteraction000376673
WBInteraction000381395
WBInteraction000389604
WBInteraction000389606
WBInteraction000391941
WBInteraction000394427
WBInteraction000398200
WBInteraction000398882
WBInteraction000407501
WBInteraction000408273
WBInteraction000429603
WBInteraction000436354
WBInteraction000440419
WBInteraction000442384
WBInteraction000443388
WBInteraction000449856
WBInteraction000460171
WBInteraction000464176
WBInteraction000465117
WBInteraction000470931
WBInteraction000512475
WBInteraction000536239
WBInteraction000536272
WBInteraction000536275
WBInteraction000536655
WBInteraction000536730
WBInteraction000536741
WBInteraction000551855
WBInteraction000552848
WBInteraction000562025
WBInteraction000577900
WBInteraction000579444
WBInteraction000583235
Map_infoMapVPosition5.53506
PositivePositive_cloneF53F4Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00005928
WBPaper00038491
WBPaper00049828
WBPaper00055090
WBPaper00064182
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene