WormBase Tree Display for Gene: WBGene00019819

WBGene00019819 SMap: S_parent: Sequence: R02D3
  Identity: Version: 2
    Name: CGC_name: aass-1
      Sequence_name: R02D3.1
      Molecular_name: R02D3.1a
        R02D3.1a.1
        CE18095
        R02D3.1b
        CE48677
        R02D3.1b.1
      Other_name: CELE_R02D3.1 Accession_evidence: NDB BX284604
      Public_name: aass-1
    DB_info: Database: AceView gene 4B3
        WormQTL gene WBGene00019819
        WormFlux gene WBGene00019819
        NDB locus_tag CELE_R02D3.1
        Panther gene CAEEL|WormBase=WBGene00019819|UniProtKB=U4PFH6
          family PTHR11133
        NCBI gene 176842
        RefSeq protein NM_001307729.4
            NM_067483.6
        TrEMBL UniProtAcc U4PFH6
            O44503
        UniProt_GCRP UniProtAcc U4PFH6
        OMIM gene 605113
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:02 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 16 Jan 2018 11:32:43 WBPerson1983 Name_change: CGC_name: aass-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: aass
    Allele: WBVar02149907
      WBVar02149906
      WBVar00414864
      WBVar00414865
      WBVar01646866
      WBVar01646867
      WBVar00414866
      WBVar00414867
      WBVar00414868
      WBVar00414869
      WBVar00414870
      WBVar00414871
      WBVar00414872
      WBVar00414873
      WBVar00414874
      WBVar01831378
      WBVar01499166
      WBVar01492363
      WBVar00092197
      WBVar00270220
      WBVar02145256
      WBVar01984257
      WBVar01802467
      WBVar00879099
      WBVar00314885
      WBVar00879100
      WBVar00879101
      WBVar00879102
      WBVar00879103
      WBVar00879104
      WBVar00879105
      WBVar00879106
      WBVar00879107
      WBVar01499608
      WBVar00879108
      WBVar00879109
      WBVar00879110
      WBVar00879111
      WBVar00879112
      WBVar00879113
      WBVar00879114
      WBVar01481030
      WBVar00879115
      WBVar00879116
      WBVar00879117
      WBVar00879118
      WBVar00879119
      WBVar00879120
      WBVar00879121
      WBVar00879122
      WBVar00879123
      WBVar01509806
      WBVar00879124
      WBVar00879125
      WBVar00879126
      WBVar00879127
      WBVar00879128
      WBVar00879129
      WBVar00879130
      WBVar00879131
      WBVar02048107
      WBVar00879132
      WBVar00879133
      WBVar00879134
      WBVar00879135
      WBVar00879136
      WBVar00879137
      WBVar00879138
      WBVar00879139
      WBVar00879140
      WBVar00879141
      WBVar00879142
      WBVar00879143
      WBVar00879144
      WBVar00879145
      WBVar00879146
      WBVar01724598
      WBVar02146278
      WBVar01450048
      WBVar01823376
      WBVar02133145
      WBVar02133146
    Strain: WBStrain00031714
    RNASeq_FPKM (74)
    GO_annotation: 00032586
      00032587
      00032588
      00032589
      00032590
      00032591
      00032592
      00032593
      00032594
      00032595
    Ortholog (36)
    Structured_description: Concise_description: The R02D3.1 gene encodes an ortholog of the human gene ALPHA-AMINOADIPATE SEMIALDEHYDE SYNTHASE (AASS; OMIM:605113), which when mutated leads to hyperlysinemia (OMIM:238700). Paper_evidence: WBPaper00004637
          Curator_confirmed: WBPerson1823
            WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable saccharopine dehydrogenase activity. Predicted to be involved in lysine biosynthetic process via aminoadipic acid. Predicted to be located in cytoplasm. Expressed in gonadal sheath cell and hypodermal cell. Human ortholog(s) of this gene implicated in hyperlysinemia. Is an ortholog of human AASS (aminoadipate-semialdehyde synthase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:9274 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17366)
  Molecular_info: Corresponding_CDS: R02D3.1a
      R02D3.1b
    Corresponding_transcript: R02D3.1a.1
      R02D3.1b.1
    Other_sequence (74)
    Associated_feature (11)
  Experimental_info: RNAi_result: WBRNAi00051122 Inferred_automatically: RNAi_primary
      WBRNAi00017312 Inferred_automatically: RNAi_primary
      WBRNAi00017315 Inferred_automatically: RNAi_primary
      WBRNAi00034526 Inferred_automatically: RNAi_primary
      WBRNAi00078534 Inferred_automatically: RNAi_primary
      WBRNAi00078635 Inferred_automatically: RNAi_primary
    Expr_pattern (7)
    Drives_construct: WBCnstr00025572
      WBCnstr00041188
      WBCnstr00041191
    Construct_product: WBCnstr00025572
    Microarray_results (22)
    Expression_cluster: WBPaper00028451:Abundant_spermatogenesis_enriched
      WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032528:L3_enriched
      WBPaper00033065:clk-1(qm30)_upregulated
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00035073:mitochondria_protein
      WBPaper00035269:cde-1_regulated
      WBPaper00035926:A.hydrophila_regulated
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_embryo_enriched
      WBPaper00037950:hypodermis_embryo_SelectivelyEnriched
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038118:aak-2(gt33)_upregulated
      WBPaper00038289:oocyte_protein
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00041071:spe-44_upregulated
      WBPaper00044616:alg-3-4_downregulated_gene
      WBPaper00044736:flat_dev_expression
      WBPaper00044746:aging_downregulated_HeatShock
      WBPaper00045521:Spermatogenic
      WBPaper00045934:wrn-1(gk99)_upregulated
      WBPaper00046121:ecdoderm_unique
      WBPaper00046337:monosomal_N2_vs_daf-2_upregulated
      WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00048988:neuron_expressed
      WBPaper00049498:npr-1(ur89)_regulated_6
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050080:rbr-2(tm3141)_downregulated
      WBPaper00050599:nicotine(0.01mM)_upregulated
      WBPaper00050698:DEP-1_interacting
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050726:starvation_regulated_HighSalt
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:hypodermis_enriched
      WBPaper00050990:hypodermis_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051265:F4_hrde-1(tm1200)_upregulated
      WBPaper00051558:aging_regulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053615:SMO-1_target
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00053814:15C_downregulated_PY79
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055648:sperm_expressed
      WBPaper00055941:atfs-1(et15)_downregulated
      WBPaper00056034:pals-25(jy9)_downregulated
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056284:ints-11(RNAi)_downregulated
      WBPaper00056443:DietaryRestriction_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00056868:P.aeruginosa_upregulated_smallRNA
      WBPaper00057154:HeatShock_downregulated_mRNA
      WBPaper00057288:Cold_upregulated_transcript
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00058691:sin-3(tm1276)_downregulated
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00058969:RIS_depleted
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059605:MUT-16_interacting
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059735:glucose_upregulated_lpin-1(RNAi)
      WBPaper00059754:E.faecalis_OG1RF_upregulated
      WBPaper00059816:crh-1(n3315)_downrgulated
      WBPaper00059895:wounding_downregulated
      WBPaper00059987:Wounding_downregulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060100:SiNP_downregulated_mRNA
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060434:pH4.33_vs_pH6.33_downrgulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:hyp7_AB_lineage
      WBPaper00061340:hyp7_C_lineage
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061377:MYRF-1_interacting
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061527:dhs-28_22199-acs-14
      WBPaper00061651:Gonadal_sheath_cell_enriched
      WBPaper00061818:ELKS-1_interacting
      WBPaper00062184:PA14_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062498:PPM-1.D_interacting
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064502:nhr-23(kry61);spe-44(fx110)_downregulated
      WBPaper00064871:PA14_downregulated_AWA
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065158:AFD_depleted
      WBPaper00065373:sek-1(km4)_upregulated_Ref
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065841:2_0
      WBPaper00065841:18_0
      WBPaper00065945:epidermis-rpoa-2(-)_downregulated_transcript
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066085:sin-3(syb2172)_upregulated
      cgc4489_group_3
      cgc4489_group_9
      WBPaper00024393:strongly_regulated_dauer_genes
      WBPaper00024671:AFD_AWB_vs_unsorted_downregulated
      WBPaper00025032:cluster_60
      WBPaper00025032:PAL-1_target_genes
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00032165:differentially_expressed_with_age_medoid_6
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035873:osm-7_regulated
      WBPaper00035873:osm-8_regulated
      WBPaper00035873:osm-11_regulated
      WBPaper00035873:osmotically_regulated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036286:Pattern_C
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_reproductive
      WBPaper00040963:TA300_up
      WBPaper00041002:HF_11d_2.0mM_Up
      WBPaper00041174:environmental
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_and_environmental
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_3h
      WBPaper00042258:DA1877_upregulated_GravidAdult
      WBPaper00045015:nhr-25(RNAi)_downregulated
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045960:L1-L4-lethargus_downregulated
      WBPaper00045960:L4-lethargus_downregulated
      WBPaper00047070:N2_UV_upregulated
      WBPaper00048624:hlh-25(ok1710)_upregulated
      WBPaper00049311:Ag-MNP_regulated
      WBPaper00049311:AgNO3_regulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00053550:daf-19(m86)_upregulated_L1
      [cgc5767]:cluster_2
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(83_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc6390]:Cluster_C
      [cgc6390]:mixed_spermatogenesis-somatic
    Interaction (39)
  Map_info: Map: IV Position: -26.7789
    Positive: Positive_clone: R02D3 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00055090
    WBPaper00055974
    WBPaper00065272
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene