WormBase Tree Display for Gene: WBGene00001340

WBGene00001340 SMap: S_parent: Sequence: CHROMOSOME_II
  Identity: Version: 1
    Name: CGC_name: etr-1 Person_evidence: WBPerson261
      Sequence_name: T01D1.2
      Molecular_name (70)
      Other_name: CELE_T01D1.2 Accession_evidence: NDB BX284602
      Public_name: etr-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:24 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: etr
    Allele: WBVar00697049
      WBVar02039822
      WBVar00697050
      WBVar00697051
      WBVar02028556
      WBVar00697052
      WBVar00697053
      WBVar00697054
      WBVar00697055
      WBVar00697056
      WBVar01474097
      WBVar00697057
      WBVar00697058
      WBVar00697059
      WBVar00697060
      WBVar00697061
      WBVar00095677
      WBVar00697062
      WBVar00697063
      WBVar00697064
      WBVar00697065
      WBVar00697066
      WBVar00697067
      WBVar01681552
      WBVar00697068
      WBVar01681553
      WBVar01681554
      WBVar00697069
      WBVar01681555
      WBVar00697070
      WBVar01681556
      WBVar00697071
      WBVar01681557
      WBVar00697072
      WBVar00697073
      WBVar01681558
      WBVar00697074
      WBVar01681559
      WBVar00697075
      WBVar00697076
      WBVar00697077
      WBVar00697078
      WBVar01412404
      WBVar00697079
      WBVar00697080
      WBVar00697081
      WBVar00697082
      WBVar00697083
      WBVar00697084
      WBVar00697085
      WBVar00697086
      WBVar00697087
      WBVar01500106
      WBVar00697088
      WBVar00697089
      WBVar00697090
      WBVar01399462
      WBVar01399463
      WBVar01498661
      WBVar01476776
      WBVar01958922
      WBVar01817565
      WBVar01500158
      WBVar01500159
      WBVar00277149
      WBVar01490970
      WBVar00354244
      WBVar01532486
      WBVar00354245
      WBVar01532487
      WBVar01532488
      WBVar00354246
      WBVar00354247
      WBVar00009041
      WBVar00354248
      WBVar00354249
      WBVar00009046
      WBVar00354250
      WBVar00354251
      WBVar00354252
      WBVar00354253
      WBVar00354254
      WBVar02129190
      WBVar00354255
      WBVar02129191
      WBVar00354256
      WBVar02129192
      WBVar02129193
      WBVar01988573
      WBVar00162865
      WBVar00162867
      WBVar01988574
      WBVar01623000
      WBVar01623001
      WBVar02017208
      WBVar01715456
      WBVar01715457
      WBVar01715458
      WBVar01715459
      WBVar01236940
      WBVar00697027
      WBVar00697028
      WBVar00697029
      WBVar00697030
      WBVar00697031
      WBVar00697032
      WBVar00697033
      WBVar01236951
      WBVar00697034
      WBVar00697035
      WBVar01291086
      WBVar01762461
      WBVar00697036
      WBVar02006350
      WBVar00697037
      WBVar01291087
      WBVar01291088
      WBVar00697038
      WBVar01291089
      WBVar00697039
      WBVar00697040
      WBVar01291092
      WBVar00697041
      WBVar00697042
      WBVar00697043
      WBVar00697044
      WBVar00697045
      WBVar00697046
      WBVar00697047
      WBVar00697048
    Possibly_affected_by: WBVar02152955
      WBVar02152954
    Strain: WBStrain00054854
      WBStrain00054853
    RNASeq_FPKM (74)
    GO_annotation (13)
    Ortholog (43)
    Paralog (13)
    Structured_description: Concise_description: etr-1 encodes a muscle-specific ELAV-type RNA-binding protein, whose homologs include Drosophila ELAV and human CUG-BINDING PROTEIN (CUGBP1; OMIM:601074); etr-1 function is required for embryonic muscle development, which suggests that ETR-1's homology to CUG-BP (implicated in myotonic dystrophy) might reflect conserved roles in development. Paper_evidence: WBPaper00003747
            WBPaper00005068
            WBPaper00012788
            WBPaper00012830
            WBPaper00012882
            WBPaper00012897
            WBPaper00013003
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable mRNA 3'-UTR binding activity. Involved in determination of adult lifespan. Located in nucleus. Expressed in body wall musculature; cloacal sphincter muscle; copulatory spicule; non-striated muscle; and somatic gonad. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 97. Is an ortholog of human CELF1 (CUGBP Elav-like family member 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0070383 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2550)
  Molecular_info: Corresponding_CDS (19)
    Corresponding_CDS_history: T01D1.2b:wp182
      T01D1.2c:wp247
    Corresponding_transcript (32)
    Other_sequence (57)
    Associated_feature (19)
  Experimental_info: RNAi_result (25)
    Expr_pattern: Expr1204
      Expr9488
      Expr13464
      Expr1026122
      Expr1030819
      Expr1155747
      Expr2011378
      Expr2029614
    Drives_construct: WBCnstr00010149
      WBCnstr00036992
    Construct_product: WBCnstr00014053
      WBCnstr00036992
    Regulate_expr_cluster (6)
    Antibody: WBAntibody00002767
    Microarray_results (74)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00032031:DConiospora_upregulated_OligoArray_24h
      WBPaper00035269:cde-1_regulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037055:DAF-16_binding_DNA
      WBPaper00037950:AVE-neuron_embryo_enriched
      WBPaper00037950:AVE-neuron_embryo_SelectivelyEnriched
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
      WBPaper00040209:B.thuringiensis_upregulated_MY18
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:flat_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Oogenic
      WBPaper00045571:germline-ablation_downregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051558:aging_regulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
      WBPaper00053599:female_vs_male_upregulated
      WBPaper00053810:nuo-6(qm200)_downregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055648:germline_expressed
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056275:P.aeruginosa_upregulated
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056826:hmc_biased
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00058725:sftb-1(cer39)_downregulated
      WBPaper00058958:100mGy-irradiation-72h_upregulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:AVE
      WBPaper00061340:Intestinal_and_rectal_muscle
      WBPaper00061340:mu_int_mu_anal
      WBPaper00061466:nath-10(icb99)_upregulated
      WBPaper00061466:nath-10(icb102)_upregulated
      WBPaper00061479:HDA-1_interacting_protein
      WBPaper00061527:cdc-42_17192-rab-5_18073
      WBPaper00061527:cids-2_2203-attf-2_2451
      WBPaper00062325:etr-1(lq61)_downregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062498:PPM-1.D_interacting
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064716:paraquat_upregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065841:7_4
      WBPaper00065841:38_2
      WBPaper00065841:102_0
      WBPaper00065841:110_0
      WBPaper00065841:110_1
      WBPaper00065841:121_0
      cgc4386_cluster_6_4
      cgc4489_group_9
      WBPaper00025032:cluster_110
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00030985:Serratia_marcesens_downregulated
      WBPaper00031003:0hr_muscle_enriched
      WBPaper00031003:hlh_1_enriched
      WBPaper00031003:total_muscle_enriched
      WBPaper00034739:N2lessDR1350
      WBPaper00035905:FBF-1_Associated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036123:Cadmium_regulated
      WBPaper00037695:WC_5-day
      WBPaper00038231:Cry5B_1.5-fold_upregulated
      WBPaper00040210:Chlorpyrifos_24C_regulated
      WBPaper00040210:Diazinon_24C_regulated
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
      WBPaper00041002:HQ_3d_0.2mM_Down
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00042236:flcn-1(ok975)_upregulated
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00045263:ProLongevity-mtROS_upregulated
      WBPaper00048989:N2_allantoin_upregulated
      WBPaper00053236:daf-16(mgDF50)_regulated_Starved
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:cluster_2
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(66_min)
      [cgc5767]:expression_class_E_pi(83_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_MD
      [cgc5767]:expression_class_MDE
      [cgc5767]:expression_class_MD_pd(23_min)
      [cgc5767]:expression_class_ME
    Interaction (42)
  Map_info: Map: II Position: -15.9026 Error: 0.013546
    Positive: Positive_clone: T01D1 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (23)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene